Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Robert L. Hendricks"'
Publikováno v:
Ophthalmology and Eye Diseases, Vol 2009, Iss 1, Pp 45-54 (2009)
The composition and location of professional antigen presenting cells (APC) varies in different mucosal surfaces. The cornea, long considered an immune-privileged tissue devoid of APCs, is now known to host a heterogeneous network of bone marrow-deri
Externí odkaz:
https://doaj.org/article/38de0c01c4914351aefafd49dee179e2
Autor:
Paul R. Kinchington, Kira L. Lathrop, Robert L. Hendricks, Anthony J. St. Leger, Michael B. Yee, Hongmin Yun
Publikováno v:
Immunity
Summary Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a136d9abdc6acdebf485138ac5a251
https://europepmc.org/articles/PMC7682749/
https://europepmc.org/articles/PMC7682749/
Autor:
Paul R. Kinchington, Benjamin R. Treat, Lyndsay Avery, Lawrence P. Kane, Anthony J. St. Leger, Kate L. Carroll, Robert L. Hendricks
Publikováno v:
Journal of Virology. 94
Herpes simplex virus 1 (HSV-1) causes a lifelong infection of neurons that innervate barrier sites like the skin and mucosal surfaces like the eye. After primary infection of the cornea, the virus enters latency within the trigeminal ganglion (TG), f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::543020629e320807a574e0033180b2db
https://doi.org/10.1128/jvi.01132-19
https://doi.org/10.1128/jvi.01132-19
Publikováno v:
The Journal of Immunology. 198:1706-1717
HSV-1 infections of the cornea range in severity from minor transient discomfort to the blinding disease herpes stromal keratitis, yet most patients experience a single episode of epithelial keratitis followed by re-establishment of a clear cornea. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3b076b6e2a3458a644f5011b7635304
https://doi.org/10.4049/jimmunol.1601310
https://doi.org/10.4049/jimmunol.1601310
Autor:
Benjamin R, Treat, Sarah M, Bidula, Anthony J, St Leger, Robert L, Hendricks, Paul R, Kinchington
Publikováno v:
J Virol
Reactivation of herpes simplex virus 1 (HSV-1) from neurons in sensory ganglia such as the trigeminal ganglia (TG) is influenced by virus-specific CD8(+) T cells that infiltrate the ganglia at the onset of latency and contract to a stable activated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfe0cfe7c49853874ae7282dfec7d0e3
https://pubmed.ncbi.nlm.nih.gov/31826989
https://pubmed.ncbi.nlm.nih.gov/31826989
Autor:
Kate L, Carroll, Lyndsay, Avery, Benjamin R, Treat, Lawrence P, Kane, Paul R, Kinchington, Robert L, Hendricks, Anthony J, St Leger
Publikováno v:
J Virol
Herpes simplex virus 1 (HSV-1) causes a lifelong infection of neurons that innervate barrier sites like the skin and mucosal surfaces like the eye. After primary infection of the cornea, the virus enters latency within the trigeminal ganglion (TG), f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34d4bf77d12448f0f86058f386466a84
https://pubmed.ncbi.nlm.nih.gov/31645447
https://pubmed.ncbi.nlm.nih.gov/31645447
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(11)
Immune privilege helps protect the cornea from damaging inflammation but can also impair pathogen clearance from this mucosal surface. Programmed death-ligand 1 (PD-L1 or B7-H1) contributes to corneal immune privilege by inhibiting the function of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c53d193dd64f76242aba4de52b0fdd
https://pubmed.ncbi.nlm.nih.gov/29669784
https://pubmed.ncbi.nlm.nih.gov/29669784
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Most of the inflammation in murine herpes simplex virus type 1 (HSV-1)-induced stromal keratitis (HSK) is due to exposure stress resulting from loss of corneal nerves and blink reflex. Corneal grafts often fail when placed on corneal beds wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38de48ff34fc2144eef77d2a5571071
https://pubmed.ncbi.nlm.nih.gov/28055100
https://pubmed.ncbi.nlm.nih.gov/28055100
Publikováno v:
The Journal of Immunology
HSV type 1 (HSV-1)–specific CD8+ T cells provide immunosurveillance of trigeminal ganglion (TG) neurons that harbor latent HSV-1. In C57BL/6 mice, the TG-resident CD8+ T cells are HSV specific and maintain a 1:1 ratio of cells recognizing an immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddda5cfc2a7983db285f02b5e70c8ac
https://doi.org/10.4049/jimmunol.1300582
https://doi.org/10.4049/jimmunol.1300582
Autor:
Carlos Medina, Alexander M. Rowe, Kira L. Lathrop, Robert L. Hendricks, Hongmin Yun, Jared E. Knickelbein
Publikováno v:
Cornea. 32:658-666
To test the therapeutic efficacy of azithromycin (AZM), a macrolide antibiotic for prolonging murine "high-risk" corneal allograft survival.Fully major histocompatibility complex-mismatched corneas were transplanted from C57BL/6 donors to BALB/c reci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0139eb8902c714f74e717f52f89b53e9
https://doi.org/10.1097/ico.0b013e318274a690
https://doi.org/10.1097/ico.0b013e318274a690