Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Robert L. Furler"'
Autor:
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott
Publikováno v:
Viruses, Vol 15, Iss 11, p 2171 (2023)
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We p
Externí odkaz:
https://doaj.org/article/e4df173514554fe9824778fa69c18045
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2608 (2023)
CD4+ T cells have orchestrated and regulated immunity since the introduction of jawed vertebrates, yet our understanding of CD4+ T cell evolution, development, and cellular physiology has only begun to be unearthed in the past few decades. Discoverie
Externí odkaz:
https://doaj.org/article/4ea601477edc424588fa1f7cd04483c0
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Human Immunodeficiency virus type 1 (HIV-1) relies on host cell metabolism for all aspects of viral replication. Efficient HIV-1 entry, reverse transcription, and integration occurs in activated T cells because HIV-1 proteins co-opt host metabolic pa
Externí odkaz:
https://doaj.org/article/ca940a969fbe4f5aa94a1837a53d83b7
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104854- (2022)
Summary: The host genetic factors conferring protection against HIV type 1 (HIV-1) acquisition remain elusive, and in particular the contributions of common genetic variants. Here, we performed the largest genome-wide association meta-analysis of HIV
Externí odkaz:
https://doaj.org/article/54145ed61d944536a089b89e3c45b8ad
Autor:
Thomas A. Premeaux, Sonia Mediouni, Ana Leda, Robert L. Furler, Susana T. Valente, Howard A. Fine, Douglas F. Nixon, Lishomwa C. Ndhlovu
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Long-term effective use of antiretroviral therapy (ART) among people with HIV (PWH) has significantly reduced the burden of disease, yet a cure for HIV has not been universally achieved, likely due to the persistence of an HIV reservoir. The
Externí odkaz:
https://doaj.org/article/3fe2d372568345668788e4b150413a5e
Autor:
Indra Sarabia, Camille L. Novis, Amanda B. Macedo, Hiroshi Takata, Racheal Nell, Juyeon C. Kakazu, Robert L. Furler, Binita Shakya, Heidi L. Schubert, Christopher P. Hill, Ana Beatriz DePaula-Silva, Adam M. Spivak, Lydie Trautmann, Vicente Planelles, Alberto Bosque
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The mitochondrial antiviral signaling protein (MAVS) is part of the cell’s innate immune mechanism of defense. MAVS mRNA is bicistronic and can give rise to a full length-MAVS and a shorter isoform termed miniMAVS. In response to viral infections,
Externí odkaz:
https://doaj.org/article/2d9d89e2d68d41a7894a9b45ae46dc68
Autor:
Gislaine Curty, Greta A. Beckerle, Luis P. Iñiguez, Robert L. Furler, Pedro S. de Carvalho, Jez L. Marston, Stephane Champiat, Jonas J. Heymann, Christopher E. Ormsby, Gustavo Reyes-Terán, Marcelo A. Soares, Douglas F. Nixon, Matthew L. Bendall, Fabio E. Leal, Miguel de Mulder Rougvie
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
In people living with HIV (PLWH), chronic inflammation can lead to cancer initiation and progression, besides driving a dysregulated and diminished immune responsiveness. HIV infection also leads to increased transcription of Human Endogenous Retrovi
Externí odkaz:
https://doaj.org/article/2f536d9c9808435bbb6863b2acbf1212
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