Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Robert L. Dormer"'
Autor:
Fiona L. L. Stratford, Jody Parker, Malcolm Martin Claude Pereira, Margaret A. McPherson, Robert L. Dormer
Publikováno v:
Biochemical Journal. 405:181-189
The CFTR [CF (cystic fibrosis) transmembrane conductance regulator] chloride channel is activated by cyclic nucleotide-dependent phosphorylation and ATP binding, but also by non-phosphorylation-dependent mechanisms. Other CFTR functions such as regul
Autor:
Robert L. Dormer, Zoe Elizabeth Clark, Margaret A. McPherson, Iolo Doull, Malcolm M.C. Pereira, Frédéric Becq, Ceinwen Menai Harris, C. Norez
Publikováno v:
Thorax. 60:55-59
Most patients with cystic fibrosis (CF) have a DeltaF508 mutation resulting in abnormal retention of mutant gene protein (DeltaF508-CFTR) within the cell. This study was undertaken to investigate DeltaF508-CFTR trafficking in native cells from patien
Autor:
Luis J. V. Galietta, Robert L. Dormer, Iolo Doull, M. Rachel Morris, Jean-Michel Vierfond, Laurence Bulteau-Pignoux, Michael A. Gray, Renaud Dérand, Frédéric Becq, Malcolm M.C. Pereira, Thierry Métayé, Margaret A. McPherson, Ceinwen M. McNeilly, Yvette Mettey
Publikováno v:
Journal of Cell Science. 114:4073-4081
A number of genetic diseases, including cystic fibrosis, have been identified as disorders of protein trafficking associated with retention of mutant protein within the endoplasmic reticulum. In the presence of the benzo(c)quinolizinium drugs, MPB-07
Autor:
Ceinwen M. McNeilly, M. R. Morris, Frédéric Becq, Malcolm M.C. Pereira, Yvette Mettey, Margaret A. McPherson, Iolo Doull, Robert L. Dormer, J-M Vierfond
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 443:S117-S120
Wild-type and the DeltaF508 mutation of the cystic fibrosis transmembrane conductance regulator (DeltaF508-CFTR) were localised by confocal imaging in DeltaF508/DeltaF508 native airway epithelial cells using a well-characterised CFTR antibody. Surfac
Autor:
Malcolm M.C. Pereira, Chris Lloyd Mills, Robert L. Dormer, Margaret A. McPherson, Kenneth J. Murray
Publikováno v:
FEBS Letters. 464:48-52
A selective cyclic nucleotide PDE5 inhibitor corrected the defective mucin secretion response to the β-agonist isoproterenol in submandibular acinar cells inhibited by antibody directed against the cystic fibrosis transmembrane conductance regulator
Autor:
Laurence Bulteau, Jean Michel Vierfond, Luis J. V. Galietta, Yvette Mettey, Thierry Métayé, Maurice Gola, Michel Joffre, Cécie Marvingt-Mounir, Bernard Verrier, Michael A. Gray, Valerie Chappe, Malcome M.C. Pereira, Frédéric Becq, Olga Zegarra-Moran, Christian Rogier, Robert L. Dormer, Barry E. Argent, Denis Sarrouilhe, Margaret A. McPherson, Renaud Dérand, Robert Tarran, Catherine Figarella, Marc Merten, Wafa Kammouni
Publikováno v:
Journal of Biological Chemistry. 274:27415-27425
Chloride channels play an important role in the physiology and pathophysiology of epithelia, but their pharmacology is still poorly developed. We have chemically synthesized a series of substituted benzo[c]quinolizinium (MPB) compounds. Among them, 6
Publikováno v:
British Journal of Pharmacology. 125:697-704
1 The cystic fibrosis gene protein, the cystic fibrosis transmembrane conductance regulator (CFTR) acts as a chloride channel and is a key regulator of mucin secretion. The mechanism by which 3-isobutyl-1-methylxanthine (IBMX) corrects the defect in
Autor:
Richard Webb, Robert L. Dormer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1233:1-6
Pancreatic rough ER ATP-binding proteins, including two isoforms of SERCA-2b Ca2+,Mg-ATPase, were identified using specific photoaffinity labelling with 8-azido-ATP. 8-Azido-ATP irreversibly inhibited Ca2+, Mg-ATPase activity only after UV irradiatio
Publikováno v:
Biochemical Journal. 293:691-695
Increases in cytoplasmic free Ca2+ concentration in rat submandibular acini were observed in response to isoprenaline (10 microM), noradrenaline (10 microM) and carbamoylcholine (10 microM). Noradrenaline and carbamoylcholine responses were decreased
Publikováno v:
Biochemical and Biophysical Research Communications. 188:1146-1152
An antibody raised against a peptide in the first nucleotide-binding domain (NBD) of CFTR [1], incorporated into intact rat submandibular acini by hypotonic swelling, inhibited beta-adrenergic stimulated mucin secretion, without affecting cyclic AMP