Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Robert L. Dedrick"'
Autor:
Wyndham H. Wilson, Chi-Chao Chan, Antonio J. Grillo-Lopez, Peng Yuan, Robert L. Dedrick, Hyuncheol Kim, Karl G. Csaky, Jay Rosenberg, Michael R. Robinson, Robert J. Lutz, Peter M. Bungay
Publikováno v:
Experimental Eye Research. 82:760-766
Rituximab is a monoclonal antibody directed against the CD20 B-cell antigen and is approved for the treatment of B-cell lymphoma. We investigated the pharmacokinetics of rituximab following intravitreal administration to assess the feasibility of tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff8208044c2ed9b2a2b5dad6e53ae5f
https://doi.org/10.1016/j.exer.2005.09.018
https://doi.org/10.1016/j.exer.2005.09.018
Autor:
Edward H. Oldfield, Robert L. Dedrick, Alexander T. Yordanov, Cynthia Sung, Kayhan Garmestani, Tung T. Nguyen, Stuart Walbridge, Yashdip S. Pannu, Markus Beitzel, Martin W. Brechbiel
Publikováno v:
Journal of Neurosurgery. 98:584-590
Object. Convection-enhanced delivery (CED), the delivery and distribution of drugs by the slow bulk movement of fluid in the extracellular space, allows delivery of therapeutic agents to large volumes of the brain at relatively uniform concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f830c8205f011756b5696eb6c9d9142
https://doi.org/10.3171/jns.2003.98.3.0584
https://doi.org/10.3171/jns.2003.98.3.0584
Autor:
Robert L. Dedrick, Peter M. Bungay, Elizabeth Fox, Cynthia McCully, Frank M. Balis, John Bacher
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:1003-1011
We measured zidovudine concentrations in blood, muscle, and brain extracellular fluid (ECF) by microdialysis and in serum ultrafiltrate and cerebrospinal fluid (CSF) samples during a continuous intravenous infusion (15 mg/kg/h) and after bolus dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b52d1ddb6ae16b25945e6ddb40bf3ab
https://doi.org/10.1124/jpet.301.3.1003
https://doi.org/10.1124/jpet.301.3.1003
Publikováno v:
Journal of Neuro-Oncology. 58:95-106
Regional delivery of drugs can offer a pharmacokinetic advantage in the treatment of localized tumors. One method of regional delivery is by intra-arterial infusion into the basilar/vertebral artery network that provides local access to infratentoria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b22f2d12a9f5074a2b058cbedd4ecff
https://doi.org/10.1023/a:1016034910875
https://doi.org/10.1023/a:1016034910875
Finite element model of antibody penetration in a prevascular tumor nodule embedded in normal tissue
Publikováno v:
Journal of Controlled Release. 74:193-202
We have developed a pharmacokinetic model for monoclonal antibodies (mAb) to aid in investigating protocols for targeting small primary tumors or sites of metastatic disease. The model describes the uptake of systemically-administered antibody by a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee48f4fc1cd477ba804a4c0913f138ff
https://doi.org/10.1016/s0168-3659(01)00317-0
https://doi.org/10.1016/s0168-3659(01)00317-0
Publikováno v:
Pharmaceutical Research. 18:361-366
Purpose. We examine the theoretical basis for calibrating microdialysis probes in vivo for pharmacokinetic experiments in which the extracellular analyte concentrations vary in time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ff8123cd387f3adab0fe3a2c1eda7b
https://doi.org/10.1023/a:1011015316327
https://doi.org/10.1023/a:1011015316327
Autor:
Edward L. Trimble, Eleanor G. Zuhowski, Robert L. Dedrick, Merrill J. Egorin, Michael A. Steller, Bartlett Dl, H. R. Alexander
Publikováno v:
Cancer Chemotherapy and Pharmacology. 43:106-114
Purpose: Because intraperitoneal (i.p.) therapy may provide a therapeutic advantage and because hyperthermia enhances carboplatin (CBDCA) cytotoxicity, we evaluated the feasibility, toxicity, and pharmacokinetics of CBDCA given via continuous hyperth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14c0150b1c8c6205b525acf4381b004
https://doi.org/10.1007/s002800050870
https://doi.org/10.1007/s002800050870
Autor:
Robert L. Dedrick, Michael F. Flessner
Publikováno v:
Journal of Controlled Release. 53:69-75
Monoclonal antibodies (MAbs), produced for specific tumor antigens, can be linked with radioisotopes or metabolic toxins and administered intraperitoneally (i.p.) to treat metastatic cancer located on the peritoneum. Despite their specific binding pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568e3a6af863ac4210b05473493f9f56
https://doi.org/10.1016/s0168-3659(97)00238-1
https://doi.org/10.1016/s0168-3659(97)00238-1
Autor:
Darrell R. Abernethy, Arthur J. Atkinson, William Budris, Ligong Chen, Jerry M. Collins, Charles E. Daniels, Robert L. Dedrick, David A. Flockhart, David M. Foster, Michael Fotis, Marilynn C. Frederiksen, Pamela D. Garzone, Kathleen M. Giacomini, Charles T. Gombar, Charles Grudzinskas, Richard J. Hargreaves, Nicholas H.G. Holford, Shiew-Mei Huang, Bridgette L. Jones, Gregory L. Kearns, Michael Klimas, S.W. Johnny Lau, Juan J.L. Lertora, Lawrence J. Lesko, Elizabeth S. Lowe, Sanford P. Markey, Raymond Miller, Paul F. Morrison, Diane R. Mould, Ameeta Parekh, Carl C. Peck, Scott R. Penzak, Sarah Robertson, Paul Rolan, Malcolm Rowland, Steven W. Ryder, Chandrahas G. Sahajwalla, Edward A. Sausville, Catherine S. Stika, Gregory M. Susla, Chris H. Takimoto, John N. Van Den Anker, Paolo Vicini, Joseph A. Ware, Ethan S. Weiner, Michael J. Wick, Janet Woodcock, Lei Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a186a2329e7600fe32122ed1ed210b
https://doi.org/10.1016/b978-0-12-385471-1.01002-3
https://doi.org/10.1016/b978-0-12-385471-1.01002-3
Autor:
Robert L. Dedrick, Malcolm Rowland
Pharmacokinetics is an important property of a drug. It determines the temporal profiles of drug and metabolites in blood and tissues, which in turn drive the magnitude and temporal pattern of response following drug administration. Poor pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cc59d9ccbb23d76ad9245f2d19a0c72
https://doi.org/10.1016/b978-0-12-385471-1.00032-5
https://doi.org/10.1016/b978-0-12-385471-1.00032-5