Milk Peptides Survive In Vivo Gastrointestinal Digestion and Are Excreted in the Stool of Infants

Autor: Andi M Markell, Elizabeth A. McCulley, Robert K. Huston, David C. Dallas, Rachel L Martin, Robert L. Beverly

Publikováno v: J Nutr

BACKGROUND: Human milk peptides released by gastrointestinal proteases have been identified with bioactivities that can benefit the infant but must first reach their respective sites of activity. Peptides in the stool either survived to or were relea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c802f8f3a2e513b29c55a8e75aa3595
https://doi.org/10.1093/jn/nxz326

Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity

Autor: Brian Scottoline, Robert L. Beverly, Jiraporn Lueangsakulthai, Prajna Woonnimani, David C. Dallas

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2377, p 2377 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 5

For bioactive milk peptides to be relevant to infant health, they must be released by gastrointestinal proteolysis and resist further proteolysis until they reach their site of activity. The intestinal tract is the likeliest site for most bioactiviti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391814a0a1df0d8b6551347bb2b46f0b
https://www.mdpi.com/1422-0067/22/5/2377

Differences in human milk peptide release along the gastrointestinal tract between preterm and term infants

Autor: Robert K. Huston, Andi M Markell, Elizabeth A. McCulley, David C. Dallas, Rachel L Martin, Robert L. Beverly

Publikováno v: Clin Nutr

Summary Background & aims Preterm infants are born with a gastrointestinal tract insufficiently developed to digesting large quantities of human milk proteins. Peptides released from the digestion of human milk proteins have been identified with bioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5baa3fda511babcb81e9b8ecd93ba6
https://pubmed.ncbi.nlm.nih.gov/32800606

Milk Proteins Are Predigested Within the Human Mammary Gland

Autor: Søren D. Nielsen, David C. Dallas, Robert L. Beverly

Publikováno v: Nielsen, S D-H, Beverly, R L & Dallas, D C 2018, ' Milk Proteins Are Predigested Within the Human Mammary Gland ', Journal of Mammary Gland Biology and Neoplasia, vol. 22, no. 4, pp. 251-261 . https://doi.org/10.1007/s10911-018-9388-0

Previous work demonstrates that proteases present in human milk release hundreds of peptides derived from milk proteins. However, the question of whether human milk protein digestion begins within the mammary gland remains incompletely answered. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8001b998ae9cd5c928593bddf6e8404c
https://doi.org/10.1007/s10911-018-9388-0

Release of functional peptides from mother's milk and fortifier proteins in the premature infant stomach

Autor: Robert L. Beverly, Mark A. Underwood, Søren D. Nielsen, David C. Dallas

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0208204 (2018)
Nielsen, S D-H, Beverly, R L, Underwood, M A & Dallas, D C 2018, ' Release of functional peptides from mother's milk and fortifier proteins in the premature infant stomach ', P L o S One . https://doi.org/10.1371/journal.pone.0208204

Digestion of milk proteins in the premature infant stomach releases functional peptides; however, which peptides are present has not been reported. Premature infants are often fed a combination of human milk and bovine milk fortifiers, but the variet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef036f220be6b7ac357afa280989d3a9
https://pubmed.ncbi.nlm.nih.gov/30496293