Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Robert L. Anderson"'
Publikováno v:
Journal of Lipid Research, Vol 6, Iss 4, Pp 577-578 (1965)
Rapid, large-scale separation of fatty acid methyl esters has been accomplished with acid-washed Florisil impregnated with silver nitrate. Recovery of material was quantitative and the peaks contained only one type of fatty acid; i.e., saturated, mon
Externí odkaz:
https://doaj.org/article/47eaf5e361e94a5692fb2fff9d84d6a4
Autor:
Marcus Henze, Weikang Ma, Robert L. Anderson, Thomas C. Irving, Henry M Gong, Carlos del Rio, Fiona L. Wong
Publikováno v:
Circ Res
Rationale: Myofilament length-dependent activation (LDA) is the key underlying mechanism of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the heart. Although alterations in LDA are common in cardiomyopathic state
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Publikováno v:
European Heart Journal. 41
B: Alterations in the length dependent activation (LDA) of left ventricular (LV) muscle fibres, the mechanistic driver of the Frank-Starling Law of the heart, are thought to mediate impaired LV function in heart failure (HF). However, little is known
Publikováno v:
European Heart Journal. 40
Background Hypertrophic cardiomyopathy (HCM) is a heritable cardiac disease characterized by hyper-contractility, hindered relaxation, and impaired exercise capacity. Conventional negative inotropes can alleviate enhanced inotropy in HCM, but do not
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Autor:
Joshua M. Gorham, Yonghong Song, Johan D. Oslob, Christine E. Seidman, Brooke C. Harrison, Jonathan G. Seidman, Marc J. Evanchik, Robert S. McDowell, Robert L. Anderson, Leslie A. Leinwand, James A. Spudich, Hiroko Wakimoto, William Wan, Hector M. Rodriguez, Eric M. Green, Marcus Henze, Raja Kawas
Publikováno v:
Science. 351:617-621
Powering down yields a healthier heart In hypertrophic cardiomyopathy (HCM), the heart muscle enlarges and becomes progressively less efficient at pumping blood. HCM can be caused by mutations in components of the sarcomere (the heart's contractile u
Autor:
Thomas C. Irving, Makenna M. Morck, Fiona L. Wong, Joshua M. Gorham, Henry Gong, Robert L. Anderson, Darshan V. Trivedi, Roger Cooke, Kathleen M. Ruppel, Christopher S. Rogers, Jonathan G. Seidman, Marcus Henze, James A. Spudich, Weikang Ma, Eric M. Green, Saswata S. Sarkar
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ATPase activity of myosin have not provided a cons
Autor:
Jonathan G. Seidman, Henry Gong, Darshan V. Trivedi, Christopher S. Rogers, Robert L. Anderson, Fiona L. Wong, Kathleen M. Ruppel, Marcus Henze, James A. Spudich, Makenna M. Morck, Weikang Ma, Eric M. Green, Saswata S. Sarkar, Roger Cooke, Thomas C. Irving
Summary:Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity and ATPase activityof myosin have not provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f066c714447f551d1719293aa31493
https://doi.org/10.1101/266783
https://doi.org/10.1101/266783
Autor:
Arvinder Sran, Raja Kawas, Sadie R Bartholomew Ingle, Hector Rodriguez, Yonghong Song, Robert L. Anderson
Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy, one of the most prevalent heritable cardiovascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4865775089766fac86f5aa1d1e04dddf
https://europepmc.org/articles/PMC5633120/
https://europepmc.org/articles/PMC5633120/
Autor:
Eric M Green, Robert M Weiss, Abhay Divekar, Sadie R Bartholomew Ingle, Marcus Henze, Raja Kawas, Lindsey Gifford, Melissa K Davis, Frank Rohret, Daniel R Thedens, Hector M Rodriguez, Marc J Evanchik, Robert L Anderson, Jessica Sieren, Christopher S Rogers, David K Meyerholz, Ferhaan Ahmad
Publikováno v:
Circulation Research. 121
Introduction: Hypertrophic cardiomyopathy (HCM) is a heritable disease of heart muscle associated with increased risk of heart failure and sudden death. Mutations in genes encoding sarcomere proteins are commonly associated with HCM. However, the mec