Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Robert L St Claire"'
Autor:
Eve-Irene Lepist, Hunter Gillies, William Smith, Jia Hao, Cassandra Hubert, Robert L St Claire, Kenneth R Brouwer, Adrian S Ray
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87548 (2014)
Inhibition of the transporter-mediated hepatobiliary elimination of bile salts is a putative mechanism for liver toxicity observed with some endothelin receptor antagonists (ERAs).Sandwich-cultured human hepatocytes were used to study the hepatobilia
Externí odkaz:
https://doaj.org/article/c42eeeca463f467d81ac31d4e10c3353
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S60-S61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d63bb1d5c20a5b47d785181cb4d48a23
https://doi.org/10.1016/j.dmpk.2020.04.127
https://doi.org/10.1016/j.dmpk.2020.04.127
Autor:
William J. Brock, Robert L. St. Claire, Yang Lu, Jason R. Slizgi, Maxwell Pan, Kenneth R. Brouwer, Kimberly M. Freeman, Kim L. R. Brouwer
Publikováno v:
Drug Metabolism and Disposition. 44:867-870
Tolvaptan is a selective V2-receptor antagonist primarily metabolized by CYP 3A. The present study investigated the hepatocellular disposition of tolvaptan and the generated tolvaptan metabolites, DM-4103 and DM-4107, as well as the potential for dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcebc99cb09ed476265f113834c68520
https://doi.org/10.1124/dmd.115.067629
https://doi.org/10.1124/dmd.115.067629
Autor:
Kim L. R. Brouwer, Robert L. St. Claire, Jeffrey L. Woodhead, Paul B. Watkins, Cen Guo, Scott Q. Siler, Kyunghee Yang, Brett A. Howell
Publikováno v:
Journal of Pharmaceutical Sciences. 105:443-459
Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization of basolateral and canalicular transporters with functional bile networks. Therefore, this cellular model is a unique tool that can be used to estimate bilia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dd0ea887544fd9508a1db790299c21
https://doi.org/10.1016/j.xphs.2015.11.008
https://doi.org/10.1016/j.xphs.2015.11.008
Autor:
Robert L. St. Claire, Kimberly M. Freeman, Kim L. R. Brouwer, Jason R. Slizgi, William J. Brock, Yang Lu, Maxwell Pan, Kenneth R. Brouwer
Publikováno v:
Toxicological Sciences. 149:237-250
Tolvaptan is a vasopressin V(2)-receptor antagonist that has shown promise in treating Autosomal Dominant Polycystic Kidney Disease (ADPKD). Tolvaptan was, however, associated with liver injury in some ADPKD patients. Inhibition of bile acid transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6611a42621853a3c31a460b5d3cd2693
https://doi.org/10.1093/toxsci/kfv231
https://doi.org/10.1093/toxsci/kfv231
Transporter-mediated alterations in bile acid disposition may have significant toxicological implications. Current methods to predict interactions are limited by the interplay of multiple transporters, absence of protein in the experimental system, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21e1a7a2b1264608c14a4e620363db0
https://europepmc.org/articles/PMC4959093/
https://europepmc.org/articles/PMC4959093/
Autor:
Robert L. St. Claire, Jonathan P. Jackson, Christopher B. Black, Kenneth R. Brouwer, Matthew K. Palmer, Kimberly Freeman
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0fcdf51468d52976db2db73565677d
https://doi.org/10.1016/j.dmpk.2017.11.238
https://doi.org/10.1016/j.dmpk.2017.11.238
Autor:
Kimberly Freeman, Matthew K. Palmer, Kenneth R. Brouwer, Jonathan P. Jackson, Robert L. St. Claire, Christopher B. Black
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc79b7c0e4b922ec32e9a519ed155639
https://doi.org/10.1016/j.dmpk.2017.11.240
https://doi.org/10.1016/j.dmpk.2017.11.240
Autor:
Cassandra H. Perry, William R. Smith, Robert L. St. Claire, John H. Ansede, Kenneth R. Brouwer
Publikováno v:
Drug Metabolism and Disposition. 38:276-280
Drug-induced cholestasis can result from the inhibition of biliary efflux of bile acids in the liver. Drugs may inhibit the hepatic uptake and/or the biliary efflux of bile acids resulting in an increase in serum concentrations. However, it is the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d409c7dbb87ed088da2505d31556dbb9
https://doi.org/10.1124/dmd.109.028407
https://doi.org/10.1124/dmd.109.028407
Autor:
John A. Begley, Jeanette Harris, Franck Rousseau, Charles Wakeford, Laurene H. Wang, Robert L. St. Claire
Publikováno v:
AIDS Research and Human Retroviruses. 20:1173-1182
Emtricitabine (FTC) is a potent deoxycytidine nucleoside analogue that was recently approved for the treatment of HIV infection. Emtricitabine is activated by intracellular phosphorylation to its 5'-triphosphate (FTC5'-TP), a competitive inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351b168829ed2eb28bccc9c75d0277f5
https://doi.org/10.1089/aid.2004.20.1173
https://doi.org/10.1089/aid.2004.20.1173