Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Robert L Rosenberg"'
Autor:
Ana Damjanović, Xiongwu Wu, Daniel R. Roe, Ada Y. Chen, Bernard R. Brooks, Robert L Rosenberg
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 88:527-539
The selectivity filter (SF) of bacterial voltage-gated sodium channels consists of four glutamate residues arranged in a C4 symmetry. The protonation state population of this tetrad is unclear. To address this question, we simulate the pore domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86036f05faeaf753477212c04e6182e9
https://doi.org/10.1002/prot.25831
https://doi.org/10.1002/prot.25831
Autor:
Vanessa L. Richards, Jennifer A. See, James T. McLaughlin, Sean C. Barron, Robert L. Rosenberg
Publikováno v:
Molecular Pharmacology. 76:253-263
Nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including nicotine addiction, Alzheimer's, schizophrenia, and depression. Therefore, they represent a critical molecular target for drug development and targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1734eea8817a323184bac60044f67fdc
https://doi.org/10.1124/mol.109.056226
https://doi.org/10.1124/mol.109.056226
Autor:
Richard F, Olivo, Joseph R, Burdo, Robert, Calin-Jageman, William E, Grisham, Monica L, Linden, Robert L, Rosenberg, Laura L, Symonds, Janice E, Thornton
Publikováno v:
Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience. 13(3)
ERIN, Educational Resources in Neuroscience, is the Society for Neuroscience's web portal to selected, high-quality materials for higher education. A Board of Editors approves resources after describing them and classifying them by topic, subtopic, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9ed5bbc7594b6adce0316cc8b7dbb5e
https://pubmed.ncbi.nlm.nih.gov/26240519
https://pubmed.ncbi.nlm.nih.gov/26240519
Publikováno v:
Molecular Pharmacology. 64:650-658
The molecular mechanisms that couple agonist binding to the gating of Cys-loop ionotropic receptors are not well understood. The crystal structure of the acetylcholine (ACh) binding protein has provided insights into the structure of the extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a6219a9bcddfcbe475416aed54529c
https://doi.org/10.1124/mol.64.3.650
https://doi.org/10.1124/mol.64.3.650
Autor:
Robert R. Maronpot, Matthew D. Breyer, Michael P. Waalkes, Darryl C. Zeldin, Jianyong Chen, Linda S. Davis, J. Alyce Bradbury, Wei Qu, Carol E. Parker, G. Jean Harry, John R. Falck, Cheng-Chung Tsao, Robert L. Rosenberg
Publikováno v:
Journal of Biological Chemistry. 276:25467-25479
A cDNA encoding a new cytochrome P450 was isolated from a mouse brain library. Sequence analysis reveals that this 1,958-base pair cDNA encodes a 57–58-kDa 502-amino acid polypeptide that is 70–91% identical to CYP2J subfamily P450s and is design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a2d80bcdefd453befc43b445d290eb
https://doi.org/10.1074/jbc.m100545200
https://doi.org/10.1074/jbc.m100545200
Publikováno v:
Molecular Pharmacology. 55:288-295
Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase metabolism of arachidonic acid, can regulate the activity of ion channels. We examined the effects of EETs on cardiac L-type Ca2+ channels that play important roles in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c1bb9aab899e48c0bca89acca7f877
https://doi.org/10.1124/mol.55.2.288
https://doi.org/10.1124/mol.55.2.288
Publikováno v:
The Journal of Neuroscience. 17:3525-3537
Capsaicin (Cap) is a pungent extract of theCapsicumpepper family, which activates nociceptive primary sensory neurons. Inward current and membrane potential responses of cultured neonatal rat dorsal root ganglion neurons to capsaicin were examined us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0986b09d3e16bce20ab879ee90473785
https://doi.org/10.1523/jneurosci.17-10-03525.1997
https://doi.org/10.1523/jneurosci.17-10-03525.1997
Autor:
Robert L. Rosenberg, Sanjay A. Desai
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2045-2049
The malaria parasite, Plasmodium falciparum , requires large amounts of nutrients to sustain its rapid growth within the human red blood cell. A recently identified ion channel on the surface of the intraerythrocytic parasite may provide direct acces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8060bb28e7fab632b2eeba9a1e4bdd54
https://doi.org/10.1073/pnas.94.5.2045
https://doi.org/10.1073/pnas.94.5.2045
Autor:
Qi-Yi Liu, Robert L. Rosenberg
Publikováno v:
Biochemical and Biophysical Research Communications. 228:252-258
We have studied the effect of a palmitoyl-L-carnitine (L-PC) on single cardiac L-type Ca channels incorporated from porcine ventricular sarcolemma into planar lipid bilayers where we could control the concentration, intracellular and/or extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e08752aa9ed976c48de894aeaf5a55
https://doi.org/10.1006/bbrc.1996.1649
https://doi.org/10.1006/bbrc.1996.1649
Publikováno v:
BMC Pharmacology
Allosteric modulation of membrane receptors is a widespread mechanism by which endogenous and exogenous agents regulate receptor function. For example, several members of the nicotinic receptor family are modulated by physiological concentrations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fab99b4697865da07cc892ac2a1705d
