Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert L Ninnis"'
Autor:
Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft, Grant Dewson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apo
Externí odkaz:
https://doaj.org/article/7dd8f93e7c6542b48b8f7611205cb9c8
Autor:
Giuseppi Infusini, Shashank Masaldan, Daisy Lio, Robert L Ninnis, Destiny Dalseno, Ahmad Wardak, Alan S Huang, Ziyan Liu, Grant Dewson, Jonathan P. Bernardini, Richard W Birkinshaw, Peter E. Czabotar, Andrew I. Webb, Jarrod J. Sandow, Iris K. L. Tan
Publikováno v:
The EMBO Journal. 40
BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associates to damage mitochondria and cause cell death. However, the dynamic structural mechanisms of this reconfiguration in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b9bd798414b6b149b476c1026a71f59
https://doi.org/10.15252/embj.2020107237
https://doi.org/10.15252/embj.2020107237
Autor:
Kristen Scicluna, Kerstin Brinkmann, Boris Reljic, Philippe Bouillet, Stephane Chappaz, Grant Dewson, Andrew P. Morokoff, Catherine Chang, Robert L Ninnis, Seong Lin Khaw, Laura F. Dagley, Ruth M. Kluck, Cathrine Hall, Andre L. Samson, Iris K. L. Tan, Gemma L. Kelly, Andrew I. Webb, Andrew J. Kueh, Marco J Herold, Daniel H.D. Gray, Hui San Chin, Michael T. Ryan, Mark F. van Delft, David C.S. Huang, Mark Xiang Li, Colin Hockings, Jarrod J. Sandow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d523948f8b15c950e0314f8d1870c4
https://doi.org/10.1038/s41467-018-07309-4
https://doi.org/10.1038/s41467-018-07309-4
Autor:
Stephane Chappaz, Michael T. Ryan, Colin Hockings, Andrew I. Webb, Boris Reljic, Kristen Scicluna, Seong Lin Khaw, Laura F. Dagley, Catherine Chang, Marco J Herold, Hui San Chin, Cathrine Hall, Grant Dewson, Ruth M. Kluck, Robert L Ninnis, Jarrod J. Sandow, Andrew J. Kueh, Daniel Hd Gray, David C.S. Huang, Mark F. van Delft, Gemma L. Kelly, Philippe Bouillet, Li X Mark, Iris K. L. Tan
Intrinsic apoptosis is critical for normal physiology including the prevention of tumor formation. BAX and BAK are essential for mediating this process and for the cytotoxic action of many anticancer drugs. BAX and BAK are thought to act in a functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ec6a8ccbca32b793de1877e1e845a3
https://doi.org/10.1101/266668
https://doi.org/10.1101/266668
Autor:
TeWhiti Rogers, Warren S. Alexander, Motti Gerlic, Donald Metcalf, Paul G Ekert, Ladina Di Rago, Grant Dewson, Seth L. Masters, Toby J. Phesse, Jason Corbin, Andrew W. Roberts, James A Rickard, Sandra Mifsud, Ashleigh R Poh, Robert L Ninnis, Louise H. Cengia, Sukhdeep K Spall, James E Vince, Cathrine Hall, Holly Anderton, Kate E. Lawlor, Matthias Ernst, Najoua Lalaoui, Joanne A. O’Donnell, Ben A. Croker, James M. Murphy, Joseph M Evans, David L. Vaux, Helen E. Abud, John Silke
Publikováno v:
Cell. 157(5):1175-1188
Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory signaling. RIPK1 also directly regulates caspase-8-mediated apoptosis or, if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5601d266c16100d9bf8cc794622a8e2
Autor:
Marie-Josee Menard, Grant Dewson, Ruth M. Kluck, Thanh Ngoc Nguyen, Robert L Ninnis, Michael T. Ryan, David A. Stroud, Stephen B. Ma, I L Tan, Sweta Iyer
Publikováno v:
Cell death and differentiation. 21(12)
In non-apoptotic cells, Bak constitutively resides in the mitochondrial outer membrane. In contrast, Bax is in a dynamic equilibrium between the cytosol and mitochondria, and is commonly predominant in the cytosol. In response to an apoptotic stimulu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be9612d44b7999b248b5febb526c6e9
https://pubmed.ncbi.nlm.nih.gov/25146925
https://pubmed.ncbi.nlm.nih.gov/25146925
Autor:
Jason M. Brouwer, Martin O'Hely, Marco Evangelista, Grant Dewson, Colin Hockings, Erinna F. Lee, Ruth M. Kluck, Robert L Ninnis, Mark G. Hinds, Khatira Anwari, Peter E. Czabotar, W.D. Fairlie
Publikováno v:
Cell Death & Disease
The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a799a79b104df1a2e8db99adbb853408
https://doi.org/10.1038/cddis.2015.105
https://doi.org/10.1038/cddis.2015.105