Zobrazeno 1 - 10
of 384
pro vyhledávání: '"Robert L Mauck"'
Autor:
Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H Zgonis, Robert L Mauck, Jaimo Ahn, Ling Qin
Publikováno v:
eLife, Vol 10 (2021)
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the development of meniscus horns from 2 weeks of age. In adult mi
Externí odkaz:
https://doaj.org/article/f623562d2d094d8fa2bb24d452a21fa8
Autor:
Su-Jin Heo, Tristan P Driscoll, Stephen D Thorpe, Nandan L Nerurkar, Brendon M Baker, Michael T Yang, Christopher S Chen, David A Lee, Robert L Mauck
Publikováno v:
eLife, Vol 5 (2016)
Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in MSC cellular and nuclear biophysical properties and queried their role in mechanosensation
Externí odkaz:
https://doaj.org/article/16c1483368c14410ae3abebcf88a3596
Autor:
Deborah J Gorth, John T Martin, George R Dodge, Dawn M Elliott, Neil R Malhotra, Robert L Mauck, Lachlan J Smith
Publikováno v:
Journal of Experimental Orthopaedics, Vol 1, Iss 1, Pp n/a-n/a (2014)
Abstract Background Inflammatory cytokines such as interleukin‐1 beta (IL‐1β) contribute to the progression of intervertebral disc degeneration. Previously we demonstrated, in vitro, that by delivering interleukin‐1 receptor antagonist (IL‐1
Externí odkaz:
https://doaj.org/article/fe2e549cefbd48b3aeabeb44363abd7b
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15717 (2010)
Fibrous scaffolds are finding wide use in the field of tissue engineering, as they can be designed to mimic many native tissue properties and structures (e.g., cardiac tissue, meniscus). The influence of fiber alignment and scaffold architecture on c
Externí odkaz:
https://doaj.org/article/146800526ad34d1ca335c123eadf1fce
Autor:
Shital Kandel, William Querido, Jessica M. Falcon, Hannah M. Zlotnick, Ryan C. Locke, Brendan Stoeckl, Jay M. Patel, Chetan A. Patil, Robert L. Mauck, Nancy Pleshko
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Standard assessment of cartilage repair progression by visual arthroscopy can be subjective and may result in suboptimal evaluation. Visible–near infrared (Vis-NIR) fiber optic spectroscopy of joint tissues, including articular cartilage and subcho
Externí odkaz:
https://doaj.org/article/89517e8ac74e45d588bc4e1a93859a6b
Autor:
Edward D. Bonnevie, Beth G. Ashinsky, Bassil Dekky, Susan W. Volk, Harvey E. Smith, Robert L. Mauck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cells interpret cues from and interact with fibrous microenvironments through the body based on the mechanics and organization of these environments and the phenotypic state of the cell. This in turn regulates mechanoactive pathways, such as
Externí odkaz:
https://doaj.org/article/d831d02e33214c92a636a23dfbdcf246
Autor:
Angela M. Gaesser, Claire Underwood, Renata L. Linardi, Kayla M. Even, Virginia B. Reef, Snehal S. Shetye, Robert L. Mauck, William J. King, Julie B. Engiles, Kyla F. Ortved
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Autologous protein solution (APS) has been used anecdotally for intralesional treatment of tendon and ligament injuries, however, its use in these injuries has never been studied in vivo. Our objective was to evaluate the effect of APS on tendon heal
Externí odkaz:
https://doaj.org/article/bb690a5f82784f52ad3c00cc877666b9
Autor:
Matthew Fainor, Sonal Mahindroo, Kerri R. Betz, Janai Augustin, Harvey E. Smith, Robert L. Mauck, Sarah E. Gullbrand
Publikováno v:
Cells Tissues Organs. :1-16
Varying degrees of hydroxyapatite (HA) surface functionalization have been implicated as the primary driver of differential osteogenesis observed in infiltrating cells. The ability to reliably create spatially controlled areas of mineralization in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c72db4b0391a6c7095b647ef8367be4b
https://doi.org/10.1159/000528965
https://doi.org/10.1159/000528965
Publikováno v:
JOR Spine, Vol 4, Iss 1, Pp n/a-n/a (2021)
Abstract Intervertebral disc (IVD) herniations, caused by annulus fibrosus (AF) tears that enable disc tissue extrusion beyond the disc space, are very prevalent, especially among adults in the third to fifth decade of life. Symptomatic herniations,
Externí odkaz:
https://doaj.org/article/4ebd8d387aa144d2b06e0a809b0fd2c8
Autor:
Sarah E. Gullbrand, Dong Hwa Kim, Beth G. Ashinsky, Edward D. Bonnevie, Harvey E. Smith, Robert L. Mauck
Publikováno v:
JOR Spine, Vol 3, Iss 2, Pp n/a-n/a (2020)
Abstract Tissue‐engineered whole disc replacements are an emerging treatment strategy for advanced intervertebral disc degeneration. A challenge facing the translation of tissue‐engineered disc replacement to clinical use are the opposing needs o
Externí odkaz:
https://doaj.org/article/3b369effd2274c65952fd071bb91c9b7