Výsledky vyhledávání - "Robert L Martuza"

Akademický článek

Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival

Autor: Howard L Kaufman, Dipongkor Saha, Samuel D Rabkin, Robert L Martuza, Praveen K Bommareddy, Hiroaki Wakimoto

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)

Background Glioblastoma (GBM), a highly immunosuppressive and often fatal primary brain tumor, lacks effective treatment options. GBMs contain a subpopulation of GBM stem-like cells (GSCs) that play a central role in tumor initiation, progression, an

Externí odkaz: https://doaj.org/article/71dfb5bed3424781825b31ac8a5284ee

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Akademický článek

Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma

Autor: Dipongkor Saha, Samuel D Rabkin, Robert L Martuza

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Temozolomide (TMZ) chemotherapy is a current standard of care for glioblastoma (GBM), however it has only extended overall survival by a few months. Because it also modulates the immune system, both beneficially and negatively, understandi

Externí odkaz: https://doaj.org/article/0af5770da7ba431180d0a4bd5963ee6d

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Akademický článek

Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells

Autor: Lei Wang, Jianfang Ning, Hiroaki Wakimoto, Shulin Wu, Chin-lee Wu, Melissa R. Humphrey, Samuel D. Rabkin, Robert L. Martuza

Publikováno v: Molecular Therapy: Oncolytics, Vol 13, Iss , Pp 58-66 (2019)

Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they ar

Externí odkaz: https://doaj.org/article/18c5510430bf466ab259585393bc969e

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Data from A Novel Oncolytic Herpes Simplex Virus that Synergizes with Phosphoinositide 3-kinase/Akt Pathway Inhibitors to Target Glioblastoma Stem Cells

Autor: Samuel D. Rabkin, Robert L. Martuza, Hiroaki Wakimoto, Ryuichi Kanai

Purpose: To develop a new oncolytic herpes simplex virus (oHSV) for glioblastoma (GBM) therapy that will be effective in glioblastoma stem cells (GSC), an important and untargeted component of GBM. One approach to enhance oHSV efficacy is by combinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84628ea7cb365dc96b73a80a589d68c3
https://doi.org/10.1158/1078-0432.c.6519531

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Data from Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models

Autor: Robert L. Martuza, Samuel D. Rabkin, Slawomir J. Antoszczyk, Cole W. Peters, Hiroaki Wakimoto, Dipongkor Saha

Purpose: Glioblastoma (GBM), a fatal brain cancer, contains a subpopulation of GBM stem-like cells (GSCs) that contribute to resistance to current therapy. Angiogenesis also plays a key role in GBM progression. Therefore, we developed a strategy to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8427f1aa5740f7455dae694bc04d0a01
https://doi.org/10.1158/1078-0432.c.6525869.v1

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