Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Robert L Chow"'
Autor:
Philip E B Nickerson, Kara Ronellenfitch, Jason McEwan, Howard Kim, Roderick R McInnes, Robert L Chow
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e27145 (2011)
Approaches for manipulating cell type-specific gene expression during development depend on the identification of novel genetic tools. Here, we report the generation of a transgenic mouse line that utilizes Vsx2 upstream sequences to direct Cre recom
Externí odkaz:
https://doaj.org/article/203cd1b9c32b4ae7a757c34ab321e484
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The corneal epithelium is continuously subjected to external stimuli that results in varying degrees of cellular damage. The use of live-cell imaging approaches has facilitated understanding of the cellular and molecular mechanisms underlying the cor
Externí odkaz:
https://doaj.org/article/920290f0013449c19e15b59cb95afa15
Autor:
Katrina V. Good, Alexia Martínez de Paz, Monica Tyagi, Manjinder S. Cheema, Anita A. Thambirajah, Taylor L. Gretzinger, Gilda Stefanelli, Robert L. Chow, Oliver Krupke, Michael Hendzel, Kristal Missiaen, Alan Underhill, Nicoletta Landsberger, Juan Ausió
Publikováno v:
Epigenetics, Vol 12, Iss 11, Pp 934-944 (2017)
MeCP2 binds to methylated DNA in a chromatin context and has an important role in cancer and brain development and function. Histone deacetylase (HDAC) inhibitors are currently being used to palliate many cancer and neurological disorders. Yet, the m
Externí odkaz:
https://doaj.org/article/1a4ada9531774b788374f89e3cf3fbfa
Autor:
Dominique M Gatti, Courtney M Gauthier, Brandon E Moeller, Rachael D FitzPatrick, Mia H E Kennedy, Victoria Pluzhnikova, Kate M E Conway, Julian Smazynski, Robert L Chow, Lisa A Reynolds
Publikováno v:
Journal of Leukocyte Biology.
Eosinophils are present in the thymus of mammals, yet their function at this site during homeostatic development is unknown. We used flow cytometry to determine the abundance and phenotype of eosinophils (here defined as SSchigh SiglecF+ CD11b+ CD45+
Autor:
Monica Mesa-Perez, Phineas T Hamilton, Alex Miranda, Nicholas Brodie, Connor O’Sullivan, Jennifer Christie, Bridget C Ryan, Robert L Chow, David Goodlett, Christopher J Nelson, Perry L Howard
Publikováno v:
Nucleic Acids Research. 50:1620-1638
The life of RNA polymerase II (RNAPII) transcripts is shaped by the dynamic formation of mutually exclusive ribonucleoprotein complexes (RNPs) that direct transcript biogenesis and turnover. A key regulator of RNA metabolism in the nucleus is the sca
Autor:
Oliver A. Krupke, Jennifer Christie, Philip E. B. Nickerson, Minyan Zhu, Monica Mesa-Peres, Perry L. Howard, Bridget C. Ryan, Li-Li Chen, Robert L. Chow, Connor O'Sullivan
Publikováno v:
Biochemistry and Cell Biology. 98:50-60
During a developmental period that extends postnatally in the mouse, proliferating multipotent retinal progenitor cells produce one of 7 major cell types (rod, cone, bipolar, horizontal, amacrine, ganglion, and Müller glial cells) as they exit the c
Autor:
Bridget C. Ryan, Connor O'Sullivan, Nicholas I. Brodie, Christopher J. Nelson, Perry L. Howard, Jennifer Christie, Mesa-Perez M, Miranda-Rodriguez A, Robert L. Chow, David R. Goodlett, Hamilton Pt
The life of RNA polymerase II (RNAPII) transcripts is shaped by the dynamic formation of mutually exclusive ribonucleoprotein complexes (RNPs) that direct transcript biogenesis and turnover. A key regulator of RNA metabolism in the nucleus is the sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f63c34d15ced808c4c13f1671fdfcf
https://doi.org/10.1101/2021.07.08.451683
https://doi.org/10.1101/2021.07.08.451683
PurposeIn this paper, we describe a novel live-imaging approach to visualize the short-term response of the mouse cornea to basal epithelial cell damage. Laser scanning confocal microscopy was used to induce precisely-defined, localized corneal basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb438c63cd5c8a5f542c7f2f17aa663b
https://doi.org/10.1101/2021.06.02.446679
https://doi.org/10.1101/2021.06.02.446679
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 144-153 (2018)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Aniridia is a rare congenital syndrome that is associated with reduced visual acuity and progressive loss of vision. Aniridia patients may also develop systemic health issues associated with defects in the pancreas, digestive, and central nervous sys
Autor:
N. Torben Bech-Hansen, Robert L. Chow, Amy S. Lee, Lisa Nguyen, Kenichi Ito, Derek Waldner, Li-Li Chen, William K. Stell, Derrick E. Rancourt, François Tremblay
Publikováno v:
Translational Vision Science & Technology
Purpose Congenital stationary night blindness 2A (CSNB2A) is a genetic retinal disorder characterized by poor visual acuity, nystagmus, strabismus, and other signs of retinal dysfunction resulting from mutations in Cacna1f -the gene coding for the po