Protease-Activated Receptor-1 Antagonist F 16618 Reduces Arterial Restenosis by Down-Regulation of Tumor Necrosis Factor α and Matrix Metalloproteinase 7 Expression, Migration, and Proliferation of Vascular Smooth Muscle Cells

Autor: Thierry Bourbon, Sylvie Sablayrolles, Robert Létienne, Stéphane N. Hatem, Michel Perez, Monique David-Dufilho, Anne-Marie Lompré, Pauline Chieng-Yane, Bruno Le Grand, Arnaud Bocquet

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2011, 336 (3), pp.643-651. ⟨10.1124/jpet.110.175182⟩

Wound healing after angioplasty or stenting is associated with increased production of thrombin and the activation of protease-activated receptor 1 (PAR1). The aim of the present study was to examine the effects of a new selective PAR1 antagonist, 2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4927582b464b95cdc23d3b41c055882
https://doi.org/10.1124/jpet.110.175182

Effects of a new PAR1 antagonist, F 16618, on smooth muscle cell contraction

Autor: Bruno Le Grand, Sylvie Sablayrolles, Luc De Vries, Michel Perez, Robert Létienne, Arnaud Bocquet

Publikováno v: European Journal of Pharmacology. 611:60-63

This study evaluated the effects of two PAR1 antagonists on vessels contracted by SFLLR. ER 121958 antagonized the SFLLR-induced contraction on rat denuded superior mesenteric artery and pig coronary artery in a non-competitive manner (IC 50 values w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca3784f5533f3cce76dbb34d1248b73
https://doi.org/10.1016/j.ejphar.2009.03.056

Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs

Autor: Anne-Dominique Degryse, Delphine Denais, Bruno Le Grand, Robert Létienne, Gareth W. John, Lydia Bel, A. M. Bessac

Publikováno v: Fundamental and Clinical Pharmacology. 20:105-113

The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd10c8b940b19f3303c485b024b0740
https://doi.org/10.1111/j.1472-8206.2006.00394.x

Donitriptan Decreases Jugular Venous Oxygen Saturation in Rats in the Absence of Cranial Vasoconstriction: An Overlooked Mechanism of Antimigraine Action?

Autor: Gareth W. John, Estelle Sole, Bruno Le Grand, Robert Létienne, Jean-Christophe Blanchet

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 315:849-857

The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds canno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdbf26a9d8154dad4921a3e66242355
https://doi.org/10.1124/jpet.105.090159

Anti‐fibrillatory effects of F17727, a new IKur blocker, in rats and rabbits with myocardial infarction or heart failure (652.17)

Autor: Christophe Pignier, Didier Junquero, Yvan Verscheure, Stéphane N. Hatem, Alain Latil, Robert Létienne, Nathalie Mougenot, Bruno Le Grand

Publikováno v: The FASEB Journal. 28

Atrial fibrillation (AF) can be triggered by myocardial infarction (MI) or heart failure (HF). The blockade of the ultra-rapid outward rectifier potassium current IKur is an attractive goal to control the repolarization of cardiac atria. F17727 was e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c7ae5f94c7fde4ddbdf8296595c586
https://doi.org/10.1096/fasebj.28.1_supplement.652.17