Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Robert L, Schlossman"'
Autor:
Tarek H. Mouhieddine, Adam S. Sperling, Robert Redd, Jihye Park, Matthew Leventhal, Christopher J. Gibson, Salomon Manier, Amin H. Nassar, Marzia Capelletti, Daisy Huynh, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Kalvis Hornburg, Henry Dumke, Muhieddine M. Itani, Cody J. Boehner, Chia-Jen Liu, Saud H. AlDubayan, Brendan Reardon, Eliezer M. Van Allen, Jonathan J. Keats, Chip Stewart, Shaadi Mehr, Daniel Auclair, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, David P. Steensma, Jacob P. Laubach, Paul G. Richardson, Jerome Ritz, Benjamin L. Ebert, Robert J. Soiffer, Lorenzo Trippa, Gad Getz, Donna S. Neuberg, Irene M. Ghobrial
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential
Externí odkaz:
https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d
Autor:
Paul G, Richardson, Susanna J, Jacobus, Edie A, Weller, Hani, Hassoun, Sagar, Lonial, Noopur S, Raje, Eva, Medvedova, Philip L, McCarthy, Edward N, Libby, Peter M, Voorhees, Robert Z, Orlowski, Larry D, Anderson, Jeffrey A, Zonder, Carter P, Milner, Cristina, Gasparetto, Mounzer E, Agha, Abdullah M, Khan, David D, Hurd, Krisstina, Gowin, Rammurti T, Kamble, Sundar, Jagannath, Nitya, Nathwani, Melissa, Alsina, R Frank, Cornell, Hamza, Hashmi, Erica L, Campagnaro, Astrid C, Andreescu, Teresa, Gentile, Michaela, Liedtke, Kelly N, Godby, Adam D, Cohen, Thomas H, Openshaw, Marcelo C, Pasquini, Sergio A, Giralt, Jonathan L, Kaufman, Andrew J, Yee, Emma, Scott, Pallawi, Torka, Amy, Foley, Mariateresa, Fulciniti, Kyle, Hebert, Mehmet K, Samur, Kelly, Masone, Michelle E, Maglio, Andrea A, Zeytoonjian, Omar, Nadeem, Robert L, Schlossman, Jacob P, Laubach, Claudia, Paba-Prada, Irene M, Ghobrial, Aurore, Perrot, Philippe, Moreau, Hervé, Avet-Loiseau, Michel, Attal, Kenneth C, Anderson, Nikhil C, Munshi, Hillard, Lazarus
Publikováno v:
N Engl J Med
BACKGROUND: In patients with newly diagnosed multiple myeloma, the effect of adding autologous stem-cell transplantation (ASCT) to triplet therapy (lenalidomide, bortezomib, and dexamethasone [RVD]), followed by lenalidomide maintenance therapy until
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b1812b4562ddb28a8653ea20d6d6cf
https://pubmed.ncbi.nlm.nih.gov/35660812
https://pubmed.ncbi.nlm.nih.gov/35660812
Autor:
Robert A. Redd, Matthew Leventhal, Irene M. Ghobrial, Nikhil C. Munshi, Christopher J. Gibson, Jerome Ritz, Amin Nassar, Chip Stewart, Jihye Park, Romanos Sklavenitis-Pistofidis, Marzia Capelletti, Cody J. Boehner, David P. Steensma, Saud H. AlDubayan, Daniel Auclair, Lorenzo Trippa, Muhieddine M. Itani, Benjamin L. Ebert, Kalvis Hornburg, Shaadi Mehr, Mark Bustoros, Robert L. Schlossman, Henry Dumke, Jacob P. Laubach, Adam S. Sperling, Gad Getz, Salomon Manier, Paul G. Richardson, Eliezer M. Van Allen, Tarek H. Mouhieddine, Sabrin Tahri, Kenneth C. Anderson, Robert J. Soiffer, Daisy Huynh, Donna Neuberg, Brendan Reardon, Chia Jen Liu, Jonathan J Keats
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1254a46ea298b8a053a3d5ec0c635a
https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d
https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d
Autor:
Edie Weller, Kaitlen Reyes, James J. Vredenburgh, Adam Boruchov, Kimberly Noonan, Paul G. Richardson, Rachid Baz, Jacob P. Laubach, Abdel Kareem Azab, Houry Leblebjian, Robert L. Schlossman, Irene M. Ghobrial, Frank G. Basile, Pamela A. Crilley, Kenneth C. Anderson, Patrick Henrick, Michael Constantine, Stacey Chuma, Nikhil C. Munshi, Kenneth H. Shain, Kalvis Hornburg, Claudia E. Paba-Prada, Philippe Armand, Diane Warren, Yuji Mishima, Lorenzo Trippa, Chia Jen Liu, Oksana Zavidij
Publikováno v:
American Journal of Hematology. 94:1244-1253
We tested the hypothesis that using CXCR4 inhibition to target the interaction between the tumor cells and the microenvironment leads to sensitization of the tumor cells to apoptosis. Eligibility criteria included multiple myeloma (MM) patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed54d4f29749ede44ac5a0056743b0db
https://doi.org/10.1002/ajh.25627
https://doi.org/10.1002/ajh.25627
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28391c5b10e9f72c5926bf7c6d10cf77
https://doi.org/10.1158/1078-0432.ccr-18-1325
https://doi.org/10.1158/1078-0432.ccr-18-1325
Autor:
Mehmet Kemal Samur, Jiye Liu, Yu-Tzu Tai, Eugenio Morelli, Paul Dowling, Xinchen Wu, Teru Hideshima, Ralph Mazitschek, Gulden Camci-Unal, Amanda McCann, Emma L Kavanagh, Robert L. Schlossman, Peter O'Gorman, Li Zhang, Takeshi Harada, Kenneth Wen, Matthew Ho, Kenneth C. Anderson, Tianzeng Chen, Sinéad Lindsay, Giada Bianchi
Publikováno v:
Leukemia
Multiple myeloma (MM) is an incurable cancer that derives pro-survival/proliferative signals from the bone marrow (BM) niche. Novel agents targeting not only cancer cells, but also the BM-niche have shown the greatest activity in MM. Histone deacetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a324b794afd44f20c64a86381a6063
http://mural.maynoothuniversity.ie/13580/
http://mural.maynoothuniversity.ie/13580/
Autor:
Lorenzo Trippa, Jacob P. Laubach, Paul G. Richardson, Elizabeth O'Donnell, Kathleen J. Lively, Robert L. Schlossman, Tianqi Chen, Irene M. Ghobrial, Andrew Yee, Philip M. Wade, Carol Ann Huff, Frank G. Basile, Nikhil C. Munshi, Jill N. Burke, Claudia E. Paba-Prada, Kenneth C. Anderson, Hannah Lyons, Cynthia C. Harrington, Noopur Raje
Publikováno v:
British Journal of Haematology. 182:222-230
We sought a regimen that incorporates optimal novel agents and balances efficacy with toxicity in transplant-ineligible multiple myeloma (MM) patients. Our study evaluated modified lenalidomide-bortezomib-dexamethasone (RVD lite) in this population a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ad6e32f89f8baa94350f214239ce0d
https://doi.org/10.1111/bjh.15261
https://doi.org/10.1111/bjh.15261
Autor:
Koen van Besien, David D. Hurd, Kouros Owzar, Vera Hars, Thomas Martin, Edward A. Stadtmauer, Marcia Wilson, Charles A. Linker, Asad Bashey, Molly Boyd, Sarah A. Holstein, Ravi Vij, Teresa Gentile, Heather Landau, Mary M. Horowitz, Natalie S. Callander, Luis Isola, Philip L. McCarthy, Robert L. Schlossman, Parameswaran Hari, Scott E. Smith, Thomas C. Shea, Hani Hassoun, Jan S. Moreb, Daniel J. Weisdorf, Paul G. Richardson, Steven M. Devine, Kenneth C. Anderson, Marcelo C. Pasquini, Richard T. Maziarz, Craig C. Hofmeister, Muzaffar H. Qazilbash, Chelsea Schultz, Cesar Rodriguez, Brian McClune, Sin-Ho Jung, Chen Jiang, Sergio Giralt
Publikováno v:
The Lancet. Haematology
In the CALGB (Alliance) 100104 study, lenalidomide versus placebo after autologous stem-cell transplantation (ASCT) was investigated for patients with newly diagnosed myeloma. That study showed improved time to progression and overall survival and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5885770bf20d691c1eaaba4dba197a56
http://europepmc.org/articles/PMC5718627
http://europepmc.org/articles/PMC5718627
Autor:
Philippe Moreau, Sung-Soo Yoon, Noppadol Siritanaratkul, Thanyaphong Na Nakorn, Jian Hou, Suman Redhu, Meral Beksac, Vania Hungria, Robert L. Schlossman, Paul G. Richardson, Jesús F. San-Miguel, Jae Hoon Lee, Andreas Guenther, Claudia Corrado, Wiesław Wiktor Jędrzejczak, Sofia Paul, Sagar Lonial, Meletios A. Dimopoulos, Hans Salwender, Monika Sopala, Hermann Einsele, Ashraf Elghandour
Publikováno v:
British Journal of Haematology. 179:66-74
Panobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression-free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0ed4d1d528a72ce1598890e1e6e002
https://doi.org/10.1111/bjh.14821
https://doi.org/10.1111/bjh.14821
Autor:
Paul G. Richardson, Benjamin L. Ebert, Constantine S. Mitsiades, Sondra L. Downey-Kopyscinski, Quinlan L. Sievers, Jacob P. Laubach, Eugen Dhimolea, Aedín C. Culhane, Joseline Raja, Olga Dashevsky, Geoffrey M. Matthews, Lawrence H. Boise, Eric S. Fischer, Megan Bariteau, Francisca Vazquez, Ricardo De Matos Simoes, Jonathan D. Licht, James E. Bradner, Michal Sheffer, Huihui Tang, Robert L. Schlossman, Tinghu Zhang, Christopher J. Ott, Nathanael S. Gray, Daniel Auclair, Aviad Tsherniak, Richard W.J. Groen, Ryosuke Shirasaki, Nicholas Kwiatkowski, Sara Gandolfi, Dennis L. Buckley, William C. Hahn, Paul J. Hengeveld, Haley Poarch, Brian J. Glassner, Joan Levy, Jonathan J Keats
Publikováno v:
Shirasaki, R, Gandolfi, S, Simoes, R D M, Matthews, G M, Buckley, D, Raja, J, Sievers, Q L, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M, Sheffer, M, Downey-Kopyscinski, S L, Hengeveld, P, Glassner, B, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A, Groen, R W J, Fischer, E, Ebert, B L, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Bradner, J, Gray, N & Mitsiades, C S 2019, ' Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins ', Blood, vol. 134 . https://doi.org/10.1182/blood-2019-130549
Blood, 134. American Society of Hematology
Blood, 134. American Society of Hematology
The discovery that thalidomide derivatives recruit the E3 ligase CRBN to induce neomorphic degradation of proteins critical for multiple myeloma (MM) cells stimulated the research into proteolysis-targeting chimeric compounds (PROTACs), led to develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010396339ca0ccc2d1148ed6135544fb
https://research.vumc.nl/en/publications/a262da2f-f489-473e-b090-d72e765547f7
https://research.vumc.nl/en/publications/a262da2f-f489-473e-b090-d72e765547f7