Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Robert L, Medcalf"'
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Tranexamic acid (TXA) is a widely used antifibrinolytic agent that has been used since the 1960’s to reduce blood loss in various conditions. TXA is a lysine analogue that competes for the lysine binding sites in plasminogen and tissue-typ
Externí odkaz:
https://doaj.org/article/2b1241028ebe4d3aa15910dc9fd65b57
Autor:
Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf, Anders E. Aneman
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-14 (2023)
Abstract Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (A
Externí odkaz:
https://doaj.org/article/1ced2b4de044430591df027ad12967a8
Autor:
Krasimir Kolev, Robert L. Medcalf
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/22d33558529f41c4a2df7e21c241c371
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105947- (2023)
Summary: Tissue-type plasminogen activator (tPA) is a serine protease that is expressed in various compartments in the brain. It is involved in neuronal plasticity, learning and memory, and addiction. We evaluated whether tPA, exogenously applied, co
Externí odkaz:
https://doaj.org/article/a58dbd9655b24ef49ff9e4fcb27df0c4
Autor:
Dominik F. Draxler, Gryselda Hanafi, Saffanah Zahra, Fiona McCutcheon, Heidi Ho, Charithani B. Keragala, Zikou Liu, David Daly, Thomas Painter, Sophia Wallace, Magdalena Plebanski, Paul S. Myles, Robert L. Medcalf
Publikováno v:
Thrombosis Journal, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Tranexamic acid (TXA) is an antifibrinolytic agent frequently used in elective surgery to reduce blood loss. We recently found it also acts as a potent immune-modulator in patients undergoing cardiac surgery. Methods Patients unde
Externí odkaz:
https://doaj.org/article/9acad31c0f7e4f36a4f5b7e6602bff63
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 5, Pp n/a-n/a (2022)
Abstract Background The fibrinolytic system plays a critical role in maintaining hemostasis. Central to fibrinolysis is the degradation of fibrin by plasmin, produced in the circulation following the activation of plasminogen by plasminogen activator
Externí odkaz:
https://doaj.org/article/c31593a2279e4d32af590604b698eaaa
Publikováno v:
HemaSphere, Vol 5, Iss 6, p e570 (2021)
The deposition and removal of fibrin has been the primary role of coagulation and fibrinolysis, respectively. There is also little doubt that these 2 enzyme cascades influence each other given they share the same serine protease family ancestry and c
Externí odkaz:
https://doaj.org/article/788f70dd9db44474bac40e85b89ab35f
Autor:
Jason S. Palazzolo, Anukreity Ale, Heidi Ho, Shweta Jagdale, Brad R. S. Broughton, Robert L. Medcalf, David K. Wright, Karen Alt, Christoph E. Hagemeyer, Be’eri Niego
Publikováno v:
Blood Advances. 7:561-574
Thrombolysis with tissue-type plasminogen activator (tPA) remains the main treatment for acute ischemic stroke. Nevertheless, tPA intervention is limited by a short therapeutic window, low recanalization rates, and a risk of intracranial hemorrhage (
Autor:
Charithani B. Keragala, Trent M. Woodruff, Zikou Liu, Be'eri Niego, Heidi Ho, Zoe McQuilten, Robert L. Medcalf
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage. t-PA can also influence the CNS in pa
Externí odkaz:
https://doaj.org/article/e1ae5ef9386e4bcfa8235cdb4995d93e
Autor:
Thomas Lillicrap, Charithani B. Keragala, Dominik F. Draxler, Jilly Chan, Heidi Ho, Stevi Harman, Be'eri Niego, Elizabeth Holliday, Christopher R. Levi, Carlos Garcia-Esperon, Neil Spratt, Prajwal Gyawali, Andrew Bivard, Mark W. Parsons, Joan Montaner, Alejandro Bustamante, Israel Fernandez Cadenas, Geoffrey Cloud, Jane M. Maguire, Lisa Lincz, Timothy Kleinig, John Attia, Simon Koblar, Monica Anne Hamilton-Bruce, Philip Choi, Bradford B. Worrall, Robert L. Medcalf
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Rationale: More than half of patients who receive thrombolysis for acute ischaemic stroke fail to recanalize. Elucidating biological factors which predict recanalization could identify therapeutic targets for increasing thrombolysis success.Hypothesi
Externí odkaz:
https://doaj.org/article/86906486acd54bac865705d696765ecb