Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study

Autor: Ashutosh Wechalekar, Gunnar Antoni, Wasfi Al Azzam, Mats Bergström, Swethajit Biswas, Chao Chen, Joseph Cheriyan, Matthew Cleveland, Louise Cookson, Paul Galette, Robert L. Janiczek, Raymond Y. Kwong, Mary Ann Lukas, Helen Millns, Duncan Richards, Ian Schneider, Scott D. Solomon, Jens Sörensen, James Storey, Douglas Thompson, Guus van Dongen, Danielle J. Vugts, Anders Wall, Gerhard Wikström, Rodney H. Falk

Publikováno v: BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-16 (2022)

Abstract Background In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of amyloid from liver, spleen and kidney in patients with systemic amyloi

Externí odkaz: https://doaj.org/article/a733adacf3434f19a23e0e826ad2a704

Non-invasive assessment of liver disease in rats using multiparametric magnetic resonance imaging: a feasibility study

Autor: Anna M. Hoy, Natasha McDonald, Ross J. Lennen, Matteo Milanesi, Amy H. Herlihy, Timothy J. Kendall, William Mungall, Michael Gyngell, Rajarshi Banerjee, Robert L. Janiczek, Philip S. Murphy, Maurits A. Jansen, Jonathan A. Fallowfield

Publikováno v: Biology Open, Vol 7, Iss 7 (2018)

Non-invasive quantitation of liver disease using multiparametric magnetic resonance imaging (MRI) could refine clinical care pathways, trial design and preclinical drug development. The aim of this study was to evaluate the use of multiparametric MRI

Externí odkaz: https://doaj.org/article/1b426a0f0e31422f831a288be36cea76

Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren’s syndrome

Autor: Nicolas Wisniacki, Azeem Saleem, Paul Galette, Coziana Ciurtin, Ruth M. Tarzi, Teresa Fuller, Kathleen Port, Robert L. Janiczek, Davide Lucchesi, Calum Gray, Marius de Groot, Pilar Jimenez-Royo, Anwar R. Tappuni, Michele Bombardieri, Michalis Kostapanos, Mats Bergström, Elena Pontarini, Natasha Jordan, Nirav Ratia, André van Maurik, Neel Patel, Lucy E Kershaw, Graham E. Searle

Publikováno v: Jimenez-royo, P, Bombardieri, M, Ciurtin, C, Kostapanos, M, Tappuni, A R, Jordan, N, Saleem, A, Fuller, T, Port, K, Pontarini, E, Lucchesi, D, Janiczek, R L, Galette, P, Searle, G E, Patel, N, Kershaw, L, Gray, C, Ratia, N, van Maurik, A, de Groot, M, Wisniacki, N, Bergstrom, M & Tarzi, R 2021, ' Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's Syndrome ', Rheumatology, vol. 60, no. 5, pp. 2396–2408 . https://doi.org/10.1093/rheumatology/keaa624
Rheumatology (Oxford, England)

Objectives To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3aca584b8b2814615a95056b6a1eea
https://doi.org/10.1093/rheumatology/keaa624

Effectively Measuring Exercise‐Related Variations in T1ρ and T2 Relaxation Times of Healthy Articular Cartilage

Autor: Andrew J. Grainger, Stephen M. McDonnell, James W. MacKay, Martin J. Graves, Fiona J. Gilbert, Alexandra R. Roberts, Scott McDonald, Robert L. Janiczek, Joshua D. Kaggie, Dimitri A. Kessler

Publikováno v: Journal of Magnetic Resonance Imaging

BACKGROUND: Determining the compositional response of articular cartilage to dynamic joint-loading using MRI may be a more sensitive assessment of cartilage status than conventional static imaging. However, distinguishing the effects of joint-loading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a8084d48a3e3ae6d6e656ade55832e
https://doi.org/10.1002/jmri.27278

Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study

Autor: Joseph Cheriyan, Alexandra Roberts, Caleb Roberts, Martin J. Graves, Ilse Patterson, Rhys A. Slough, Rosemary Schroyer, Disala Fernando, Subramanya Kumar, Sarah Lee, Geoffrey J.M. Parker, Lea Sarov‐Blat, Carmel McEniery, Jessica Middlemiss, Dennis Sprecher, Robert L. Janiczek

Publikováno v: Journal of magnetic resonance imaging : JMRI. 56(2)

Methods for accurate quantification of lung fluid in heart failure (HF) are needed. Dynamic contrast-enhanced (DCE)-MRI may be an appropriate modality.DCE-MRI evaluation of fraction of fluid volume in the interstitial lung space (vProspective, single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0009b8f5b50c947739e38068e17c17e4
https://pubmed.ncbi.nlm.nih.gov/35332601