Výsledky vyhledávání - "Robert L, Fine"

Akademický článek

Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo

Autor: Robert L. Fine, Yuehua Mao, Dario Garcia-Carracedo, Gloria H. Su, Wanglong Qiu, Uri Hochfeld, Gwen Nichols, Yong-Liang Li, Richard D. Dinnen, Anthony Raffo, Paul W. Brandt-Rauf

Publikováno v: Biomedicines, Vol 11, Iss 2, p 258 (2023)

Any gene therapy for cancer will be predicated upon its selectivity against cancer cells and non-toxicity to normal cells. Therefore, safeguards are needed to prevent its activation in normal cells. We designed a minimal p14ARF promoter with upstream

Externí odkaz: https://doaj.org/article/63ac97b61c3745b18f46b4184dca843e

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Akademický článek

C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo

Autor: Robert L. Fine, Yuehua Mao, Richard Dinnen, Ramon V. Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N. Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W. Brandt-Rauf

Publikováno v: Biomedicines, Vol 11, Iss 1, p 137 (2023)

We previously demonstrated that a synthetic monomer peptide derived from the C-terminus of p53 (aa 361–382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. The major problem with the peptide was its short half-li

Externí odkaz: https://doaj.org/article/90a0fac39c5d4ce1a697f6695fbb8e57

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Akademický článek

Economic Analysis of Hospital Palliative Care: Investigating Heterogeneity by Noncancer Diagnoses

Autor: Peter May, Charles Normand, Egidio Del Fabbro, Robert L. Fine, R. Sean Morrison, Isabel Ottewill, Chessie Robinson, J. Brian Cassel

Publikováno v: MDM Policy & Practice, Vol 4 (2019)

Background. Single-disease-focused treatment and hospital-centric care are poorly suited to meet complex needs in an era of multimorbidity. Understanding variation in palliative care’s association with treatment choices is essential to optimizing i

Externí odkaz: https://doaj.org/article/5c4ac9b21f8544b993b82b94f53fca04

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Supplementary Figure 3 from Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC

Autor: Robert L. Fine, Paul Brandt-Rauf, Gloria H. Su, Gwen Nichols, Vesna N. Slavkovich, Nicholas Cassai, Wanglong Qiu, Yuehua Mao, Richard D. Dinnen

PDF - 1108 KB, Supplementary Figure 3: A, Flow cytometric analysis for apoptosis/necrosis. MIA PaCa-2 cells +/- AAA, or PAC (25 μM) for 24h, and stained with Anx V/ PI. Apoptosis = Anx+/PI- (bottom right of each panel); Necrosis= Anx+/PI+ cells (top

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9675792d94af468a1bb4684ea3565992
https://doi.org/10.1158/1535-7163.22498788.v1

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Supplementary Figure 5 from Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC

Autor: Robert L. Fine, Paul Brandt-Rauf, Gloria H. Su, Gwen Nichols, Vesna N. Slavkovich, Nicholas Cassai, Wanglong Qiu, Yuehua Mao, Richard D. Dinnen

PDF - 359KB, Supplementary Figure 5: Accumulation of intracellular O2 .- radicals in PANC-1 and MIA-PACA cells treated with AAA. A, B, Intracellular accumulation of O2.-radical in PANC-1 A, or MIA-PACA-2 B, cell lines +/-ATO, AA, or DSF using DHE. C,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2319301108d8056c711d8ef5e93caece
https://doi.org/10.1158/1535-7163.22498782.v1

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Supplementary Figure 6 from Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC

Autor: Robert L. Fine, Paul Brandt-Rauf, Gloria H. Su, Gwen Nichols, Vesna N. Slavkovich, Nicholas Cassai, Wanglong Qiu, Yuehua Mao, Richard D. Dinnen

PDF - 345KB, Supplementary Figure S6: A, ROS accumulation (MitoSOX Red) and cell death (Trypan blue) in AAA-treated PANC-1 cells treated with increasing concentrations of MnTMPyP, (10 muM MnTMPyP). B, ROS accumulation and cell death (Trypan blue) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0eaeda8eb72c7e3dd2af3738606e7
https://doi.org/10.1158/1535-7163.22498779

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Supplementary Figure 1 from Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC

Autor: Robert L. Fine, Paul Brandt-Rauf, Gloria H. Su, Gwen Nichols, Vesna N. Slavkovich, Nicholas Cassai, Wanglong Qiu, Yuehua Mao, Richard D. Dinnen

PDF - 964KB, Supplementary Figure 1: A, AsPC-1 or BxPC-3 cells were treated +/- ATO (2 μM), AA (100 μM) with increasing concentrations of DSF and % Trypan-blue (TPB)+ cells determined after 48h. B, Cell death in PANC-1, 27sk or MCF-10F cells +/- AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fac8b4daea62a61e8a62556a4f16310
https://doi.org/10.1158/1535-7163.22498794.v1

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Supplementary Figure 2 from Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC

Autor: Robert L. Fine, Paul Brandt-Rauf, Gloria H. Su, Gwen Nichols, Vesna N. Slavkovich, Nicholas Cassai, Wanglong Qiu, Yuehua Mao, Richard D. Dinnen

PDF - 213KB, Supplementary Figure 2: A, Cell death determined by release of glucose 6-phosphate dehydrogenase. Results shown as a maximum release as determined by addition of cell lysis buffer, n=3. B, ATP analysis. PANC-1 cells +/- AAA or PAC, or MI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e51887ca85b8f996e257b56afd1463f
https://doi.org/10.1158/1535-7163.22498791.v1

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