Výsledky vyhledávání - "Robert Kypta"

Akademický článek

Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets

Autor: Tanja Spethmann, Lukas Clemens Böckelmann, Vera Labitzky, Ann‐Kristin Ahlers, Jennifer Schröder‐Schwarz, Sarah Bonk, Ronald Simon, Guido Sauter, Hartwig Huland, Robert Kypta, Udo Schumacher, Tobias Lange

Publikováno v: Molecular Oncology, Vol 15, Iss 7, Pp 1956-1969 (2021)

Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ‐catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microar

Externí odkaz: https://doaj.org/article/7121450caf7b4f2591affd5fcf9ae787

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Akademický článek

Sox2 promotes tamoxifen resistance in breast cancer cells

Autor: Marco Piva, Giacomo Domenici, Oihana Iriondo, Miriam Rábano, Bruno M Simões, Valentine Comaills, Inmaculada Barredo, Jose A López‐Ruiz, Ignacio Zabalza, Robert Kypta, Maria d M Vivanco

Publikováno v: EMBO Molecular Medicine, Vol 6, Iss 1, Pp 66-79 (2013)

Abstract Development of resistance to therapy continues to be a serious clinical problem in breast cancer management. Cancer stem/progenitor cells have been shown to play roles in resistance to chemo‐ and radiotherapy. Here, we examined their role

Externí odkaz: https://doaj.org/article/42b2c474b81e4b609e38a99f1375b5d6

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Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Autor: Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver

Publikováno v: Clinical Science. 136:1405-1423

Intestinal fibrosis and stricture formation is an aggressive complication of Crohns disease (CD), linked to increased morbidity and costs. The present study investigates the contribution of Wingless-Int-1 (Wnt) signalling to intestinal fibrogenesis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1935c75aad09cc58520371966448219
https://doi.org/10.1042/cs20210889

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Intravital imaging of Wnt/β-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis

Autor: Konstantin Stoletov, Saray Sanchez, Irantzu Gorroño, Miriam Rabano, Maria d. M. Vivanco, Robert Kypta, John D. Lewis

Publikováno v: Journal of cell science.

Wnt signalling has been implicated as a driver of tumour cell metastasis, but less is known about which branches of Wnt signalling are involved and when they act in the metastatic cascade. Here, using a unique intravital imaging platform and fluoresc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9105c861f13b21f8d9df2cea4d02236
https://pubmed.ncbi.nlm.nih.gov/36621522

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Dickkopf-3 alters the morphological response to retinoic acid during neuronal differentiation of human embryonal carcinoma cells

Autor: Rocío Jiménez, Alfonso, Irantzu, Gorroño-Etxebarria, Miriam, Rabano, Maria dM, Vivanco, Robert, Kypta

Publikováno v: Developmental neurobiology. 74(12)

Dickkopf-3 (Dkk-3) and Dkkl-1 (Soggy) are secreted proteins of poorly understood function that are highly expressed in subsets of neurons in the brain. To explore their potential roles during neuronal development, we examined their expression in Nter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfbf73b94335c1e79e493fb42a4da452
https://pubmed.ncbi.nlm.nih.gov/24909558

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