Výsledky vyhledávání - "Robert Kulawy"

Akademický článek

Pharmacodynamic modeling of anti-cancer activity of tetraiodothyroacetic acid in a perfused cell culture system.

Autor: Hung-Yun Lin, Cornelia B Landersdorfer, David London, Ran Meng, Chang-Uk Lim, Cassie Lin, Sharon Lin, Heng-Yuan Tang, David Brown, Brian Van Scoy, Robert Kulawy, Lurdes Queimado, George L Drusano, Arnold Louie, Faith B Davis, Shaker A Mousa, Paul J Davis

Publikováno v: PLoS Computational Biology, Vol 7, Iss 2, p e1001073 (2011)

Unmodified or as a poly[lactide-co-glycolide] nanoparticle, tetraiodothyroacetic acid (tetrac) acts at the integrin αvβ3 receptor on human cancer cells to inhibit tumor cell proliferation and xenograft growth. To study in vitro the pharmacodynamics

Externí odkaz: https://doaj.org/article/5eedb33720284bba9ec8a469709b8972

Zobrazit plný text záznamu

Akademický článek

The Combination of Rifampin plus Moxifloxacin Is Synergistic for Suppression of Resistance but Antagonistic for Cell Kill of Mycobacterium tuberculosis as Determined in a Hollow-Fiber Infection Model

Autor: G. L. Drusano, Nicole Sgambati, Adam Eichas, David L. Brown, Robert Kulawy, Arnold Louie

Publikováno v: mBio, Vol 1, Iss 3 (2010)

ABSTRACT Moxifloxacin is under development for expanded use against Mycobacterium tuberculosis. Rifampin is a mainstay of therapy. We examined the interaction of moxifloxacin plus rifampin for log-phase and nonreplicating persister (NRP) organisms. F

Externí odkaz: https://doaj.org/article/346a155c92eb441da601c67a03e408da

Zobrazit plný text záznamu

Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system

Autor: Camilly P. Pires de Mello, Jonathan R. Adams, George L. Drusano, Robert Kulawy, Matthew Shudt, Ashley N. Brown

Publikováno v: European Journal of Pharmaceutical Sciences. 111:443-449

Drug-resistant influenza is a significant threat to global public health. Until new antiviral agents with novel mechanisms of action become available, there is a pressing need for alternative treatment strategies with available influenza antivirals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcd052f3c90bd1cbc7ed58617af2e05
https://doi.org/10.1016/j.ejps.2017.10.027

Zobrazit plný text záznamu

Hollow-Fiber Pharmacodynamic Studies and Mathematical Modeling To Predict the Efficacy of Amoxicillin for Anthrax Postexposure Prophylaxis in Pregnant Women and Children

Autor: Weiguo Liu, Arnold Louie, Robert Kulawy, George L. Drusano, Brian VanScoy

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:5946-5960

Amoxicillin is considered an option for postexposure prophylaxis of Bacillus anthracis in pregnant and postpartum women who are breastfeeding and in children because of the potential toxicities of ciprofloxacin and doxycycline to the fetus and child.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ba54f83d464f8ac25de411cb9d521d
https://doi.org/10.1128/aac.02616-12

Zobrazit plný text záznamu

Impact of Spores on the Comparative Efficacies of Five Antibiotics for Treatment of Bacillus anthracis in an In Vitro Hollow Fiber Pharmacodynamic Model

Autor: David L. Brown, Henry S. Heine, George L. Drusano, Brian VanScoy, Robert Kulawy, Arnold Louie

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:1229-1239

Bacillus anthracis , the bacterium that causes anthrax, is an agent of bioterrorism. The most effective antimicrobial therapy for B. anthracis infections is unknown. An in vitro pharmacodynamic model of B. anthracis was used to compare the efficacies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d355afa88d9af25dbafa2f97d323513
https://doi.org/10.1128/aac.01109-10

Zobrazit plný text záznamu

Evaluation of Once-Daily Vancomycin against Methicillin-Resistant Staphylococcus aureus in a Hollow-Fiber Infection Model

Autor: Jürgen B. Bulitta, Thomas P Lodise, Robert Kulawy, Arnold Louie, Anthony M. Nicasio, Rebecca E D'Hondt, George L. Drusano

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:682-686

For methicillin-resistant Staphylococcus aureus (MRSA) infections, data suggest that the clinical response is significantly better if the total vancomycin area under the concentration-time curve (AUC)/MIC ratio is ≥400. While the AUC/MIC ratio is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c46671554e4af96fde678462c05fce
https://doi.org/10.1128/aac.05664-11

Zobrazit plný text záznamu

Ertapenem Pharmacokinetics and Pharmacodynamics during Continuous Ambulatory Peritoneal Dialysis

Autor: Joseph Roglieri, George L. Drusano, Shari Meola, Darren W. Grabe, Robert Kulawy, Katie E. Cardone, Rachid Daoui, Thomas P. Lodise

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:725-730

Scant data exist for the pharmacokinetics (PK) of ertapenem in patients on continuous ambulatory peritoneal dialysis (CAPD). The goals of this study were to characterize the PK profile of ertapenem during CAPD, determine the extent of ertapenem penet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740f4d8717e26ab04526df872679172f
https://doi.org/10.1128/aac.05515-11

Zobrazit plný text záznamu

Differential Effects of Linezolid and Ciprofloxacin on Toxin Production by Bacillus anthracis in an In Vitro Pharmacodynamic System

Autor: David L. Brown, Arnold Louie, Kari Holman, Weiguo Liu, Brian VanScoy, Henry S. Heine, George L. Drusano, Robert Kulawy, Terry Abshire

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:513-517

Bacillus anthracis causes anthrax. Ciprofloxacin is a gold standard for the treatment of anthrax. Previously, using the non-toxin-producing ΔSterne strain of B. anthracis , we demonstrated that linezolid was equivalent to ciprofloxacin for reducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26b0600e0b6cb5a312e845fc1821926
https://doi.org/10.1128/aac.05724-11

Zobrazit plný text záznamu

Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases

Autor: Ian A. Critchley, Brian VanScoy, David Brown, Robert Kulawy, Weiguo Liu, Caroline Grasso, George L. Drusano, Ronald N. Jones, Mariana Castanheira, George A. Williams, Arnold Louie, Dirk Thye

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:258-270

New broad-spectrum β-lactamases such as KPC enzymes and CTX-M-15 enzymes threaten to markedly reduce the utility of our armamentarium of β-lactam agents, even our most potent drugs, such as carbapenems. NXL104 is a broad-spectrum non-β-lactam β-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72167ac0b9d6cb9511513a601144557
https://doi.org/10.1128/aac.05005-11

Zobrazit plný text záznamu

Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa

Autor: Nadzeya Bahniuk, Brian VanScoy, Robert A. Bonomo, Robert Kulawy, Jürgen B. Bulitta, David Brown, George L. Drusano, Sarah M. Drawz, Arnold Louie, Holland DeFiglio, Steven Fikes

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:231-242

The panoply of resistance mechanisms in Pseudomonas aeruginosa makes resistance suppression difficult. Defining optimal regimens is critical. Cefepime is a cephalosporin whose 3′ side chain provides some stability against AmpC β-lactamases. We exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a61312d427122499c5a0725c6c475
https://doi.org/10.1128/aac.05252-11

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání