Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert Kotloski"'
Publikováno v:
Epilepsia. 55:1264-1273
Summary Objective The principal molecular targets of conventional antiseizure drugs consist of ligand-gated and voltage-gated ion channels and proteins subserving synaptic function. Inhibition of the receptor tyrosine kinase TrkB limits epileptogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83858e0440ebf9fd10a58dc9af2eb038
https://doi.org/10.1111/epi.12671
https://doi.org/10.1111/epi.12671
Autor:
Robert Kotloski, Ramona M. Rodriguiz, Xiaoju Daniell, Gregory A. Taylor, Lindsey E. Phillips, Robert I. Greene, Stanley C. Henry, Kristy Crooks, William C. Wetsel, Lino Tessarollo
Publikováno v:
Genes, Brain and Behavior. 7:786-795
P311 is an 8-kDa protein that is expressed in many brain regions, particularly the hippocampus, cerebellum and olfactory lobes, and is under stringent regulation by developmental, mitogenic and other physiological stimuli. P311 is thought to be invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4840b4db5b48cf68d0225baa8b99e77
https://doi.org/10.1111/j.1601-183x.2008.00420.x
https://doi.org/10.1111/j.1601-183x.2008.00420.x
Autor:
Scott J. Myers, Phuong Le, Raymond Dingledine, Dennis C. Liotta, Hasan A. Irier, Adam French, Matthew T. Geballe, Yesim Altas Tahirovic, Robert Kotloski, Ewa Gruszecka-Kowalik, Woo-Baeg Choi, Hongjie Yuan, Lawrence J. Wilson, Stephen F. Traynelis, Polina Lyuboslavsky, James O. McNamara, James P. Snyder, Keith W Easterling
Publikováno v:
Journal of Medicinal Chemistry. 51:5506-5521
Enantiomeric propanolamines have been identified as a new class of NR2B-selective NMDA receptor antagonists. The most effective agents are biaryl structures, synthesized in six steps with overall yields ranging from 11-64%. The compounds are potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873377656192885b3c6bec2d946da06f
https://doi.org/10.1021/jm8002153
https://doi.org/10.1021/jm8002153
Autor:
James O. McNamara, Xiao-Ping He, Robert Kotloski, Luis F. Parada, Serge Nef, Bryan W. Luikart
Publikováno v:
Neuron. 43:31-42
Epileptogenesis is the process whereby a normal brain becomes epileptic. We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in the hippocampus during epileptogenesis and that BDNF-mediated act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7074f71f6b17476ab158881f4ade9a9d
https://doi.org/10.1016/j.neuron.2004.06.019
https://doi.org/10.1016/j.neuron.2004.06.019
Autor:
Robert Kotloski, James O. McNamara
Publikováno v:
Hippocampus.
Elucidating the mechanisms of epileptogenesis in molecular terms can identify targets for therapies aimed at preventing epileptogenesis or limiting its progression. Genetic perturbations have implicated signaling by the neurotrophin, BDNF, and its re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa8ddb1422d4a7897818a93f6a951e4
https://doi.org/10.1002/hipo.20673
https://doi.org/10.1002/hipo.20673
Publikováno v:
Advances in Behavioral Biology ISBN: 9780387243801
Epilepsy is a common and frequently devastating neurological disorder, affecting approximately 1% of the population. Among the diverse forms, limbic epilepsy (synonyms include complex partial epilepsy, temporal lobe epilepsy, psychomotor epilepsy) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c8cadeb548e68a1db0fa841f4a0ec8
https://doi.org/10.1007/0-387-26144-3_24
https://doi.org/10.1007/0-387-26144-3_24
Publikováno v:
Progress in brain research. 135
The long-term effects of repeated brief seizures on spatial memory and hippocampal neuronal populations were assessed in kindled rats. Rats that experienced a range of 3 afterdischarges to 134 secondary generalized tonic-clonic (Class V) seizures evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63e79067a21037d2475e5180b4f191f9
https://pubmed.ncbi.nlm.nih.gov/12143373
https://pubmed.ncbi.nlm.nih.gov/12143373
Autor:
Yesim A. Tahirovic, Matthew Geballe, Ewa Gruszecka-Kowalik, Scott J. Myers, Polina Lyuboslavsky, Phuong Le, Adam French, Hasan Irier, Woo-baeg Choi, Keith Easterling, Hongjie Yuan, Lawrence J. Wilson, Robert Kotloski, James O. McNamara, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, James P. Snyder
Publikováno v:
Journal of Medicinal Chemistry; Aug2008, Vol. 51 Issue 18, p5506-5521, 16p
Autor:
Susan R. Rittling, David T. Denhardt, Raymond Dingledine, Robert Kotloski, Karin Borges, Esben S. Sørensen, Marla Gearing
Publikováno v:
Aarhus University
Borges, K, Gearing, M, Rittling, S, Sørensen, E S, Kotloski, R, Denhardt, D T & Dingledine, R 2008, ' Characterization of osteopontin expression and function after status epilepticus ', Epilepsia, vol. 49, pp. 1675-1685 .
Borges, K, Gearing, M, Rittling, S, Sørensen, E S, Kotloski, R, Denhardt, D T & Dingledine, R 2008, ' Characterization of osteopontin expression and function after status epilepticus ', Epilepsia, vol. 49, pp. 1675-1685 .
Osteopontin (gene symbol spp1) is a highly glycosylated multifunctional phosphoprotein that influences adhesion, migration, cell survival, and inflammation (reviewed in Denhardt et al., 2001a, 2001b; Scatena et al., 2007). It is expressed in many tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214719ef7bd6feed69c9dff40fdfac07
https://pure.au.dk/portal/en/publications/characterization-of-osteopontin-expression-and-function-after-status-epilepticus(a0c2cb60-eeee-11dc-b919-000ea68e967b).html
https://pure.au.dk/portal/en/publications/characterization-of-osteopontin-expression-and-function-after-status-epilepticus(a0c2cb60-eeee-11dc-b919-000ea68e967b).html