Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Robert Kopf"'
Autor:
Wei Chen, Siegfried Stolz, Vincent Wegbecher, Dixy Parakkattel, Christina Haeuser, Nuria Sancho Oltra, Ravuri S. K. Kishore, Steven Bond, Christian Bell, Robert Kopf
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intact
Externí odkaz:
https://doaj.org/article/feee32a1221d465fa7f3f189f70d93f9
Autor:
Gabriel Hoffmann, Nuria Sancho Oltra, Bernd Steinhuber, Wei Chen, Robert Kopf, Alfred Ross, Satya Krishna Kishore Ravuri, Christian Bell, Steven Bond
Publikováno v:
Journal of chromatography. A. 1652
Poloxamer 188 (P188) is formulated in proteinaceous therapeutics as an alternative surfactant to polysorbate because of its good chemical stability and surfactant properties, which enable interfacial protection, preventing visible and sub-visible par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509727901751d04606ad894c9fcfc6d5
https://pubmed.ncbi.nlm.nih.gov/34237484
https://pubmed.ncbi.nlm.nih.gov/34237484
Autor:
Robert Kopf, Denis Klemm, Tobias Graf, Christoph A. Paschen, Christian Bell, Claudia Müller, Janina Pfaff, Cosimo Pinto
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 192
Polysorbates and Poloxamer 188 constitute the most common surfactants used in biopharmaceutical formulations owing to their excellent protein-stabilizing properties and good safety profiles. In recent years, however, a vast number of reports concerni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f2a5a62b54b45ef09b58d2013c3f2b
https://pubmed.ncbi.nlm.nih.gov/33002754
https://pubmed.ncbi.nlm.nih.gov/33002754
Autor:
Stijn H.S. Koshari, Henning Koehn, Rudolf Schuller, Thomas Buckel, Robert Kopf, Steffen Lippold, Isidro E. Zarraga
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 132:24-34
Determination of excipient content in drug formulation is an important aspect of pharmaceutical formulation development and for analytical testing of the formulation. In this study, the influence of polysorbate subspecies, in particular mono- and pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ce37790f2e99a23bf67c4e1b1908ee
https://doi.org/10.1016/j.jpba.2016.09.033
https://doi.org/10.1016/j.jpba.2016.09.033
Autor:
Lu Dai, Davy Guillarme, Nisana Andersen, Alexandre Goyon, Michael Molhoj, Cinzia Stella, Tao Chen, Michael Leiss, Feng Yang, Robert Kopf, Bingchuan Wei
Publikováno v:
Journal of Chromatography. A, Vol. 1615 (2020) P. 460740
The identification and quantification of post-translational modifications (PTMs) is a crucial step required during the development of therapeutic proteins. In particular, the characterization of charge variants separated by cation exchange chromatogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbfb944ea36a5f18e18bc7b8b36fe06
https://doi.org/10.1016/j.chroma.2019.460740
https://doi.org/10.1016/j.chroma.2019.460740
Autor:
Robert Kopf
Unter Herzinsuffizienz versteht man eine nachlassende Leistung des Herzmuskels. Das Herz der Katze ist nicht mehr fähig, die benötigte Menge Blut durch den Körper zu pumpen, damit Organe und Gewebe ausreichend mit Sauerstoff und Nährstoffen verso
Autor:
Robert Kopf
Intermittent claudication is a common disease in which narrowed arteries reduce blood flow to the limbs. If it is caused by a buildup of plaques in your blood vessels (atherosclerosis), you're at risk of developing limb ischemia, stroke and heart att
Autor:
Robert Kopf
Sciatica refers to neuralgic pain that radiates from the lumbar area to the buttock and the back of your thigh and calf. The sciatic nerve is the largest nerve in the body.The pain is sharp, burning, tingling, excruciating, like a jolt or electric sh
Autor:
Robert Kopf
Glaucoma is a group of eye conditions that damage the optic nerve, which is important to good vision. This damage is caused by an increased pressure in the eye and can lead to blindness. Mostly there are no warning signs. The effect is so gradual tha
Autor:
Robert Kopf
Bronchitis is a respiratory disease, very common and an inflammation or irritation of the lining of the bronchial tubes, which carry air to and from the lungs. When these tubes get infected, they swell and mucus forms inside them. This makes it hard