Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Robert Kisilevsky"'
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2091-2101 (2005)
Macrophages (Mϕ) at sites of acute tissue injury accumulate and export cholesterol quickly. This metabolic activity is likely dependent on the physiological function of a major acute-phase protein, serum amyloid A 2.1 (SAA2.1), that is synthesized b
Externí odkaz:
https://doaj.org/article/36cf904626364ad0ab4d8c1fecc42cc7
Autor:
Robert Kisilevsky, Shui Pang Tam
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 12, Pp 2257-2269 (2003)
Serum amyloid A 2.1 (SAA2.1) suppresses ACAT and stimulates cholesteryl ester hydrolase (CEH) activities in cholesterol-laden macrophages, and in the presence of a cholesterol transporter and an extracellular acceptor, there is a marked increase in t
Externí odkaz:
https://doaj.org/article/c4839844c0bc48fc81617b09b1ac989e
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 9, Pp 1410-1420 (2002)
We show that murine macrophages that have ingested cell membranes as a source of cholesterol exhibit a marked increase in acyl-CoA:cholesterol acyl tranferase (ACAT) activity. Exposure of these macrophages to acute-phase high-density lipoprotein (HDL
Externí odkaz:
https://doaj.org/article/cfe1245fff644b23a91f662617cbcbff
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3867 (2008)
During episodes of acute-inflammation high-density lipoproteins (HDL), the carrier of so-called good cholesterol, experiences a major change in apolipoprotein composition and becomes acute-phase HDL (AP-HDL). This altered, but physiologically importa
Externí odkaz:
https://doaj.org/article/8b155357dd43460dbe71ae22987e51e1
Autor:
Erik Lundgren, Per Westermark, Robert Kisilevsky, Ana M. Damas, John B. Ancsin, Erik Hermansson, Fredrik Noborn, Jan Johansson, Jin-Ping Li, Ingrid Dacklin, Xiao Zhang, Paul O'Callaghan, Jenny Presto, Maria João Saraiva
Publikováno v:
Proceedings of the National Academy of Sciences. 108:5584-5589
Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily in the heart and periphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75afea667991d7acdd17bc6943605ed2
https://doi.org/10.1073/pnas.1101194108
https://doi.org/10.1073/pnas.1101194108
Autor:
Robert Kisilevsky, Yiming Xu, Rahul Vohra, Jie Sui, Jason Z. Vlahakis, Walter A. Szarek, Ian Crandall
Publikováno v:
Biochemical Pharmacology. 73:632-642
The effect of sulfated cyclodextrins on Plasmodium falciparum cultures was determined. alpha-, beta-, and gamma-Cyclodextrins having equal degrees of sulfation inhibited parasite viability to a similar degree, a result suggesting that the ring size o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5132bc1c91913a6d9f3e089438243438
https://doi.org/10.1016/j.bcp.2006.10.030
https://doi.org/10.1016/j.bcp.2006.10.030
Publikováno v:
Amyloid. 14:21-32
Amyloid formation in vivo is a much more complicated process than studies of in vitro protein/peptide fibrillogenesis would lead one to believe. Amyloidogenesis in vivo involves multiple components, some no less important than the amyloidogenic prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88577620cc73daa1f83e7f9996a8c4cf
https://doi.org/10.1080/13506120601116419
https://doi.org/10.1080/13506120601116419
Publikováno v:
Amyloid. 13:123-134
Serum amyloid A (SAA) is a family of proteins encoded by four related genes. Of the four, isoforms 1.1 and 2.1 are acute phase proteins synthesized by the liver. They become major components of the HDL plasma fraction during acute tissue injury and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b6623791dbd8559ee32779e8bc65bd
https://doi.org/10.1080/13506120600877201
https://doi.org/10.1080/13506120600877201
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2091-2101 (2005)
Macrophages (Mphi) at sites of acute tissue injury accumulate and export cholesterol quickly. This metabolic activity is likely dependent on the physiological function of a major acute-phase protein, serum amyloid A 2.1 (SAA2.1), that is synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d35f4260520146a78964ca985c34448
https://doi.org/10.1194/jlr.m500191-jlr200
https://doi.org/10.1194/jlr.m500191-jlr200
Autor:
Robert Kisilevsky, Walter A. Szarek, Elena Elimova, Ali Berkin, Sandra Marone, Shridhar Bhat, John B. Ancsin
Publikováno v:
The American Journal of Pathology. 164:2127-2137
Two novel sugars, 2-acetamido-1,3,6-tri-O-acetyl-2,4-dideoxy-α- and β-d-xylo-hexopyranoses, have been synthesized and their effects on heparan sulfate biosynthesis using primary mouse hepatocytes in tissue culture have been assessed. At concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a9f3a45c61114c716ed44b41073969b
https://doi.org/10.1016/s0002-9440(10)63771-6
https://doi.org/10.1016/s0002-9440(10)63771-6