Genome -wide stress sensitivity moderates the stress-depression relationship in a nationally representative sample of adults

Autor: Trent Davidson, David B. Braudt, Robert Keers, Elham Assary, Kathleen Mullan Harris, Jason D. Boardman

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract We re-evaluate the findings of one of the most cited and disputed papers in gene-environment interaction (GxE) literature. In 2003, a paper was published in Science in which the authors demonstrated that the relationship between stress and d

Externí odkaz: https://doaj.org/article/42f29e04dd3e4f7c885d62132e8b5db6

Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours.

Autor: Robert Keers, Inti Pedroso, Gerome Breen, Kathy J Aitchison, Patrick M Nolan, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Leonard C Schalkwyk, Cathy Fernandes

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38263 (2012)

Disruption of the circadian rhythm is a key feature of bipolar disorder. Variation in genes encoding components of the molecular circadian clock has been associated with increased risk of the disorder in clinical populations. Similarly in animal mode

Externí odkaz: https://doaj.org/article/7016b763792444098cf9b53b590806d9

Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram

Autor: Ole Köhler-Forsberg, Peter McGuffin, Katherine J. Aitchison, Marcella Rietschel, Robert Keers, Rudolf Uher, Anne Farmer, Ole Mors, Wolfgang Maier, Joanna Hauser

Publikováno v: Köhler-Forsberg, O, Keers, R, Uher, R, Hauser, J, Maier, W, Rietschel, M, McGuffin, P, Farmer, A E, Aitchison, K J & Mors, O 2023, ' Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram ', Psychological Medicine, vol. 53, no. 6, pp. 2522-2530 . https://doi.org/10.1017/S003329172100444X

BackgroundPersonality traits may predict antidepressant discontinuation and response. However, previous studies were rather small, only explored a few personality traits and did not include adverse drug effects nor the interdependency between antidep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02882fb490030a7aaa81c53b8d400995
https://pure.au.dk/portal/da/publications/dimensions-of-temperament-and-character-as-predictors-of-antidepressant-discontinuation-response-and-adverse-reactions-during-treatment-with-nortriptyline-and-escitalopram(86600b1b-a64e-40cd-838f-7893b9b1268f).html

Genetic architecture of Environmental Sensitivity reflects multiple heritable components: a twin study with adolescents

Autor: Robert Keers, Helena M. S. Zavos, Elham Assary, Michael Pluess, Eva Krapohl

Publikováno v: Molecular Psychiatry

Humans differ substantially in how strongly they respond to similar experiences. Theory suggests that such individual differences in susceptibility to environmental influences have a genetic basis. The present study investigated the genetic architect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b843c4e817f886bb65555ed264d31f
https://doi.org/10.1038/s41380-020-0783-8

Genome -wide stress sensitivity moderates the stress-depression relationship in a nationally representative sample of adults

Autor: Kathleen Mullan Harris, Trent Davidson, Elham Assary, David B. Braudt, Robert Keers, Jason D. Boardman

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

We re-evaluate the findings of one of the most cited and disputed papers in gene-environment interaction (GxE) literature. In 2003, a paper was published in Science in which the authors demonstrated that the relationship between stress and depression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f790e6d31bec2dbea63fe23b8a53770
https://doi.org/10.1038/s41598-021-98684-4