Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Robert Kamen"'
Autor:
Tariq Ghayur, Donald Kufe, Sheldon Ratnofsky, Yutaka Emoto, Robert Kamen, Christopher Quinlan, Pramod Pandey, Yinyin Huang, Hamish Allen, Winnie W. Wong, Rakesh Datta, Surender Kharbanda, Margaret Hugunin, Robert V. Talanian
Publikováno v:
The Journal of Experimental Medicine
Recent studies have shown that protein kinase C (PKC) delta is proteolytically activated at the onset of apoptosis induced by DNA-damaging agents, tumor necrosis factor, and anti-Fas antibody. However, the relationship of PKC delta cleavage to induct
Autor:
Cynthia Johnston, Elizabeth Towne, Tara Seshadri, Michael Paskind, Robert Kamen, Feng-Yi Wei, Laura Rodman, Scott Wardwell, Hamish Allen, Winnie W. Wong, Daniel E. Tracey, Ping Li, Linda Herzog, Subhashis Banerjee, Jochen G. Salfeld, Jack McDowell, Simon Franklin
Publikováno v:
Cell. 80(3):401-411
IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/lch-1. We generated ICE-deficient mice and observed that they
Autor:
Nigel Walker, M. Terranova, Robert V. Talanian, Nancy J. Bump, Tariq Ghayur, Daniel E. Tracey, John A. Mankovich, A. Möller, W. Houy, E. Orlewicz, Margaret Hugunin, A. Summani, Robert Kamen, Winnie W. Wong, C.A. Pratt, L.D. Hammill, Simon Franklin, L.C. Dang, C.R. Ferenza, J.P. Welch, Kenneth Dale Brady, Maria Hackett, L. McGuiness, Michael Paskind, Linda Herzog, Pedro Reis, L. Xiong
Publikováno v:
Cell. 78:343-352
Interleukin-1β-converting enzyme (ICE) proteolytically cleaves pro-IL-1β to its mature, active form. The crystal structure at 2.5 A resolution of a recombinant human ICE-tetrapeptide chloromethylketone complex reveals that the holoenzyme is a homod
Autor:
Margaret Hugunin, Robert V. Talanian, L. Sekut, H. Allen, A. Carter, Michael Paskind, T. Ghayur, Daniel E. Tracey, D. Butler, S. Banerjee, Winnie W. Wong, Linda Herzog, L. Quintal, Robert Kamen
Publikováno v:
Nature. 386(6625)
Interferon-gamma-inducing factor (IGIF, interleukin-18) is a recently described cytokine that shares structural features with the interleukin-1 (IL-1) family of proteins and functional properties with IL-12. Like IL-12, IGIF is a potent inducer of in
Autor:
L. Quintal, Robert V. Talanian, Winnie W. Wong, Linda Herzog, A. Carter, L. Sekut, Daniel E. Tracey, Margaret Hugunin, H. Allen, S. Banerjee, D. Butler, Robert Kamen, T. Ghayur
Publikováno v:
Shock. 7:84
Publikováno v:
Nucleic Acids Research. 9:6305-6322
We have localized with respect to the genomic DNA sequence the capped 5'-termini of polyoma virus late region mRNAs. A minimum of fifteen different purine termini were found within a 94 base pair region (66.36 to 68.12 map units, nt 5075-5168) immedi
Publikováno v:
Cell. 9:481-487
The 19S and 16S polyoma virus late mRNAs have been separated on sucrose-formamide density gradients and translated in vitro. The 16S RNA codes only for polyoma capsid protein VP1, while the 19S RNA codes in addition for capsid protein VP2. Since the
Publikováno v:
Molecular and Cellular Biology. 2:737-751
The 5'-flanking DNA sequences involved in the specific and efficient transcription of the polyoma virus early region have been investigated. Sequence requirements for efficient in vivo expression differed from those in vitro. Deletion of DNA located
Autor:
Robert Kamen, H. Shure
Publikováno v:
Cell. 7:361-371
The different species of polyoma virus-spedific RNA molecules present in the cytoplasm of 3T6 cells 30 hr after viral infection have been characterized by molecular hybridization between nonradioactive polyadenlated RNA, fractionated by sedimentation
Autor:
Elizabeth A. Wang, Robert E. Donahue, Steven C. Clark, Robert Kamen, David G. Nathan, Prabhat K. Sehgal, Gordon G. Wong, David Stone
Publikováno v:
Nature. 321:872-875
Certain proteins are known to play an important part in the proliferation, differentiation and functional activation of haematopoietic progenitor cells in vitro1,2. These proteins include erythropoietin and various colony-stimulating factors (CSFs),