Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Robert K. Slany"'
Autor:
Robert K. Slany
Publikováno v:
HemaSphere, Vol 8, Iss 6, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/f43f450431674e1b97044b890c83e339
Publikováno v:
Haematologica, Vol 107, Iss 11 (2022)
The homeobox transcription factors HoxA9 and Meis1 are causally involved in the etiology of acute myeloid leukemia. While HoxA9 alone immortalizes cells, cooperation with Meis1 is necessary to induce a full leukemic phenotype. Here, we applied degron
Externí odkaz:
https://doaj.org/article/d2eb23fd7bc34c579de763c832e3950f
Autor:
Amit Sharma, Nidhi Jyotsana, Razif Gabdoulline, Dirk Heckl, Florian Kuchenbauer, Robert K. Slany, Arnold Ganser, Michael Heuser
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearran
Externí odkaz:
https://doaj.org/article/2c4504fcbbc6476ebb3bdac800d86d4d
Autor:
Maria-Paz Garcia-Cuellar, Christian Büttner, Christoph Bartenhagen, Martin Dugas, Robert K. Slany
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 310-322 (2016)
MLL fusions are leukemogenic transcription factors that enhance transcriptional elongation through modification of chromatin and RNA Pol II. Global transcription rates and chromatin changes accompanying the transformation process induced by MLL-ENL w
Externí odkaz:
https://doaj.org/article/cabe070e4af9489996ee8a2cc666ea6a
Autor:
Emanuel Maethner, Maria-Paz Garcia-Cuellar, Constanze Breitinger, Sylvia Takacova, Vladimir Divoky, Jay L. Hess, Robert K. Slany
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1553-1566 (2013)
Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here, we provide evidence that MLL-ENL also inhibits Polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies iden
Externí odkaz:
https://doaj.org/article/640a9373d2684bb197a168258ccb394f
Publikováno v:
Haematologica, Vol 100, Iss 7 (2015)
Hox homeobox transcription factors drive leukemogenesis efficiently only in the presence of Meis or Pbx proteins. Here we show that Pbx3 and Meis1 need to dimerize to support Hox-induced leukemia and we analyze the molecular details of this cooperati
Externí odkaz:
https://doaj.org/article/0043e592c6704e408ba6897cfa96e1b1
Autor:
Robert K. Slany
Publikováno v:
Haematologica, Vol 94, Iss 7 (2009)
Mixed lineage leukemia is a very aggressive blood cancer that predominantly occurs in pediatric patients. In contrast to other types of childhood acute leukemias, mixed lineage leukemia presents with a dismal prognosis and despite the availability of
Externí odkaz:
https://doaj.org/article/6c39d27b48c64110aa464245f4c7e69e
The transcription factor CCAAT-enhancer binding factor alpha (C/ebpα) is a master controller of myeloid differentiation that is expressed as long (p42) and short (p30) isoform. Mutations within theCEBPAgene selectively deleting p42 are frequent in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f61842cae4d08eba764d8e0cb004f769
https://doi.org/10.1101/2023.05.16.540903
https://doi.org/10.1101/2023.05.16.540903
Autor:
Jay L. Hess, Robert K. Slany, Thomas A. Milne, Mohamad El-Osta, Zhaohai Yang, Corrado Caslini
Supplementary Figure 5 from Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ef77fb268334ded9381887f75d327a
https://doi.org/10.1158/0008-5472.22365705
https://doi.org/10.1158/0008-5472.22365705
Supplementary Methods from Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188ab8a0b2751d25a077c095344f37e1
https://doi.org/10.1158/0008-5472.22364442.v1
https://doi.org/10.1158/0008-5472.22364442.v1