Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert K. Perrone"'
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 151
This paper describes the development of a simple reversed-phase HPLC method that can quantitate trace amounts of a polymeric degradants (BMT-041910) in asunaprevir drug substance and formulated drug product with quantitation limits of ∼0.05% w/w. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a459a82e835fa8be6149a6c9b1ff1b0
https://pubmed.ncbi.nlm.nih.gov/29353808
https://pubmed.ncbi.nlm.nih.gov/29353808
From Bench to Humans: Formulation Development of a Poorly Water Soluble Drug to Mitigate Food Effect
Autor:
Neil Mathias, Dilbir S. Bindra, Zongyun Huang, Preetanshu Pandey, Brian Yan, Timothy Eley, Robert K. Perrone, Chandra Vemavarapu, John R. Crison, Rhye Hamey
Publikováno v:
AAPS PharmSciTech. 15:407-416
This study presents a formulation approach that was shown to mitigate the dramatic food effect observed for a BCS Class II drug. In vitro (dissolution), in vivo (dog), and in silico (GastroPlus®) models were developed to understand the food effect a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f77b8d8dea3356a09a39796aea48ab
https://doi.org/10.1208/s12249-013-0069-4
https://doi.org/10.1208/s12249-013-0069-4
Autor:
Piyasena Hewawasam, Steven I. Dworetzky, Yadagiri Pendri, Lorraine Pajor, Qi Gao, Valentin K. Gribkoff, John E. Starrett, Martinez Eduardo J, Joanne T. Trojnacki, Debra J. Post-Munson, Christopher G. Boissard, Krishnaswamy Yeleswaram, Robert K. Perrone, Nicholas A. Meanwell, Jay O. Knipe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1023-1026
3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a56228112f2fba1136e1270d9daa2a
https://doi.org/10.1016/s0960-894x(02)00101-4
https://doi.org/10.1016/s0960-894x(02)00101-4
Autor:
John D. Dimarco, Shankar Swaminathan, Brian Burke, Thomas P. Kissick, Oak K. Kim, Bin Zheng, Janak Singh, Kenneth J. Natalie, Goodrich Jason, Juliya Livshits, Matthew A. Brown, John A. Grosso, Zhinong Gao, Michael J. Humora, Anthony P. Dutka, Peter Hans Ermann, David R. Kronenthal, Gerard A. Crispino, Richard H. Mueller, John A. Wichtowski, Jeffrey T. North, Joanne J. Bronson, Jack Z. Gougoutas, Yasutsugu Ueda, Dane M. Springer, Peter Schierling, Bing Yu Luh, James E. Heikes, Dau-Ming Hsieh, Anne J. Pullockaran, Bo Zhang, Robert K. Perrone, Mei C. Lai, and Theodor W. Denzel, Yunhui Zhang
Publikováno v:
Organic Process Research & Development. 4:488-497
A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem (6R-trans)-E-7-[[[[2,5-dichloro-4-[3-[(carboxymethyl)amino]-3-oxo-1-propenyl]phenyl]-thio]-acetyl]amino]-4-[[(2-carboxy-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030fc232263c59de1340816a124920ab
https://doi.org/10.1021/op0002850
https://doi.org/10.1021/op0002850
Autor:
John A. Wichtowski, Yuan Tsai, Ken Denbleyker, Peter F. Misco, Jollie D. Godfrey, Janak Singh, Raymond F. Miller, Junius M. Clark, John D. Matiskella, Michael J. Pucci, Richard H. Mueller, Michael J. Humora, Boyhan Brenda T, Thomas P. Kissick, Joan Fung-Tomc, Stan V. D'Andrea, David R. Kronenthal, Robert K. Perrone, Yasutsuga Ueda, Annie Pullockaran, Murray A. Kaplan, Sterzycki Roman Z, James E. Heikes, Shelley E. Hoeft, Fritz Alan W, Truc Chi Vu, Rita Fox, Joanne J. Bronson, Jeffery T. North, D P Bonner, Thomas W. Hudyma
Publikováno v:
Tetrahedron. 56:5687-5698
Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625ad66e9507d6b330714a80db975bfd
https://doi.org/10.1016/s0040-4020(00)00418-x
https://doi.org/10.1016/s0040-4020(00)00418-x
Publikováno v:
International journal of pharmaceutics. 201(2)
Three solid state forms of stavudine designated forms I, II and III have been identified and characterized. Forms I and II are anhydrous polymorphs whereas form III is hydrated and is pseudopolymorphic with forms I and II. Physico-chemical and thermo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c643a1441a46cf9121c84079b48b0ee
https://pubmed.ncbi.nlm.nih.gov/10878328
https://pubmed.ncbi.nlm.nih.gov/10878328
Publikováno v:
American Journal of Health-System Pharmacy. 46:258-259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d955863b8d49e251156023457bf1d2f
https://doi.org/10.1093/ajhp/46.2.258a
https://doi.org/10.1093/ajhp/46.2.258a