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of 198
pro vyhledávání: '"Robert K. Oldham"'
Autor:
Robert K. Oldham, Robert O. Dillman
At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many
Autor:
Robert K. Oldham
Publikováno v:
Cancer biotherapyradiopharmaceuticals. 32(4)
Autor:
Melissa Amber Burgess, Susan Matlow, Steven Attia, Katherine Anne Thornton, Gregory M. Cote, Daryl Barnett, Sant P. Chawla, Scott H. Okuno, Robert K. Oldham, Karla V. Ballman
Publikováno v:
Journal of Clinical Oncology. 37:TPS11077-TPS11077
TPS11077 Background: The response rates of advanced soft tissue sarcomas (STS) to single-agent, first-line anthracycline are typically less than 25%. P-glycoprotein 1 (P-gp), a cell membrane drug efflux pump, is believed to be a resistance mechanism
Autor:
Shuen-Kuei Liao, Robert K. Oldham
Publikováno v:
Journal of Cancer Metastasis and Treatment. 4:3
Autor:
Robert K. Oldham, Susan E. Bates, Robert W. Robey, Suneet Shukla, Suresh V. Ambudkar, Daryl Barnett, Tito Fojo, Elizabeth M. Finley
Publikováno v:
Biochemical Pharmacology. 75:1302-1312
Cellular expression of ATP-binding cassette (ABC) transport proteins, such as P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), or ABCG2, is known to confer a drug-resistant phenotype. Thus, the development of effective transporte
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 15:175-183
Biochemical modulation of 5-Fluorouracil activity with Leucovorin has been well documented in colorectal cancer. Several studies have shown increased efficacy of 5-fluorouracil in combination with alpha interferon. We therefore initiated a phase II t
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 13:71-80
CBT-1, a natural product, was studied in an escalating dose Phase I clinical trial with doxorubicin at 60 mg/m2. CBT-1 was administered by mouth at doses from 200 mg/m2 to 600 mg/m2. The drug was given for 7 days and doxorubicin administered intraven