Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

Autor: Gregory Segala, Marcela A. Bennesch, Nastaran Mohammadi Ghahhari, Deo Prakash Pandey, Pablo C. Echeverria, François Karch, Robert K. Maeda, Didier Picard

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Endosomal fusion depends on the HOPS and CORVET complexes but whether and how their subunits modulate signal transduction is not fully understood. Here, the authors show that the HOPS/CORVET subunits Vps11 and Vps18 are E3 ubiquitin ligases that are

Externí odkaz: https://doaj.org/article/ce61553035444a5d9885729d73ae928a

The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility.

Autor: Robert K Maeda, Jessica L Sitnik, Yohan Frei, Elodie Prince, Dragan Gligorov, Mariana F Wolfner, François Karch

Publikováno v: PLoS Genetics, Vol 14, Iss 7, p e1007519 (2018)

Although thousands of long non-coding RNAs (lncRNA) have been identified in the genomes of higher eukaryotes, the precise function of most of them is still unclear. Here, we show that a >65 kb, male-specific, lncRNA, called male-specific abdominal (m

Externí odkaz: https://doaj.org/article/7811d1c6767e41e687f3d162559fdc46

Hox gene regulation in the central nervous system of Drosophila

Autor: Maheshwar eGummalla, Sandrine eGaletti, Robert K Maeda, François eKarch

Publikováno v: Frontiers in Cellular Neuroscience, Vol 8 (2014)

Hox genes specify the structures that form along the anteroposterior (AP) axis of bilateria. Within the genome, they often form clusters where, remarkably enough, their position within the clusters reflects the relative positions of the structures th

Externí odkaz: https://doaj.org/article/22409efe61ca416bafe15362bbd8d858

Identification of a micropeptide and multiple secondary cell genes that modulate Drosophila male reproductive success

Autor: Emi Nagoshi, Jasmine Grey, Jean-Christophe Billeter, Dragan Gligorov, François Karch, Clément Immarigeon, Léa Fabbro, Sofie Y. N. Delbare, Pedro Machado Almeida, Robert K. Maeda, Mariana F. Wolfner, Yohan Frei

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118(15):e2001897118. NATL ACAD SCIENCES

Significance In many species, mating induces physiological changes in the female that increase the reproductive success of the mating pair. The postmating response (PMR) is caused by male seminal fluid proteins interacting with the female reproductiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f94c95f01fa5c0d8ab8eabb554227
http://europepmc.org/articles/PMC8053986

abd-A regulation by the iab-8 noncoding RNA.

Autor: Maheshwar Gummalla, Robert K Maeda, Javier J Castro Alvarez, Henrik Gyurkovics, Swetha Singari, Kevin A Edwards, François Karch, Welcome Bender

Publikováno v: PLoS Genetics, Vol 8, Iss 5, p e1002720 (2012)

The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qua

Externí odkaz: https://doaj.org/article/96065f397e66408f83d1523cf57922dc