Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert K. Kui"'
Autor:
Yun Zu M. Wang, Richard T. Waldron, Osvaldo Rey, James Sinnett-Smith, Rodrigo Jacamo, Steven H. Young, Robert K. Kui, Enrique Rozengurt
Publikováno v:
Journal of Biological Chemistry. 284:13434-13445
Rapid protein kinase D (PKD) activation and phosphorylation via protein kinase C (PKC) have been extensively documented in many cell types cells stimulated by multiple stimuli. In contrast, little is known about the role and mechanism(s) of a recentl
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 283:G1098-G1106
In previous studies, we found that apical and basolateral EGF receptors (EGFR) on primary canine gastric monolayers decreased paracellular permeability, evident by increased transepithelial electrical resistance (TER) and decreased flux of [3H]mannit
Publikováno v:
Biochemical and biophysical research communications. 430(1)
Metformin, a widely used anti-diabetic drug, is emerging as a potential anticancer agent but the mechanisms involved remain incompletely understood. Here, we demonstrate that the potency of metformin induced AMPK activation, as shown by the phosphory
Publikováno v:
The Journal of biological chemistry. 286(1)
We examined whether protein kinase D1 (PKD1), the founding member of a new protein kinase family, plays a critical role in intestinal epithelial cell proliferation. Our results demonstrate that PKD1 activation is sustained, whereas that of PKD2 is tr
Autor:
Monica C. Chen, Robert K. Kui, Enrique Rozengurt, Eduardo Perez Salazar, Andrew H. Soll, Travis E. Solomon
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 283(4)
Previous studies found that epidermal growth factor (EGF) decreased paracellular permeability in gastric mucosa, but the other physiological regulators and the molecular mechanisms mediating these responses remain undefined. We investigated the role
Publikováno v:
Gastroenterology. 144:S-293
Publikováno v:
Cancer Research. 73:4007-4007
The mTOR pathway is aberrantly stimulated in many cancer cells, including pancreatic ductal adenocarcinoma (PDAC), and thus it is a potential target for therapy. However, the mTORC1/S6K axis also mediates negative feedback loops that attenuate signal
Publikováno v:
Gastroenterology. 142:S-649
Publikováno v:
Gastroenterology. 142:S-129
Publikováno v:
Gastroenterology. 142:S-67