Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert K. Hamatake"'
Autor:
Zhi Hong, Robert K. Hamatake, Jae Hoon Shim, Zhijun Zhang, Yung-Hyo Koh, Jean-Luc Girardet, Li-Tain Yeh, Wen Xu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:429-437
Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. However, their low genetic barriers against resistance development, cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b334947514798953b3520b098bf518
https://doi.org/10.1128/aac.01032-06
https://doi.org/10.1128/aac.01032-06
Autor:
Ilia Korboukh, Uyen Boyle, Nanhua Yao, Huanming Chen, Esmir Gunic, Weijian Zhang, Hong Woo Kim, Matthew J. Allan, Shahul Nilar, Jean-Luc Girardet, Stanley A. Lang, Wen Xu, Cheryl Jenket, Zhijun Zhang, Zhi Hong, Yung-Hyo Koh, Robert K. Hamatake, Martha De La Rosa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4444-4449
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c031e880bd5c6399781472929ae5605
https://doi.org/10.1016/j.bmcl.2006.06.048
https://doi.org/10.1016/j.bmcl.2006.06.048
Autor:
Wen Xu, Jean-Luc Girardet, Zhi Hong, Michelle Walker, Zhijun Zhang, Jae Hoon Shim, Robert K. Hamatake
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:2772-2781
Mutations in and around the catalytic site of the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) are associated with resistance to nucleoside RT inhibitors (NRTIs), whereas changes in the hydrophobic pocket of the RT are at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd1201e7a813600fc4b1af169250592
https://doi.org/10.1128/aac.00127-06
https://doi.org/10.1128/aac.00127-06
Publikováno v:
Expert Opinion on Investigational Drugs. 13:289-293
The biannual HEP DART conference in Hawaii provided an intimate setting for members of the viral hepatitis community to exchange ideas and information. The leaders in clinical research and drug development gathered with scientists to discuss the rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a260255af9807a2a3dca9ac198f95ad
https://doi.org/10.1517/13543784.13.3.289
https://doi.org/10.1517/13543784.13.3.289
Publikováno v:
Expert Opinion on Investigational Drugs. 12:1281-1295
Chronic hepatitis B remains a public health problem of global importance despite the availability of an effective vaccine. Between 350 and 400 million people, approximately 6% of the world's population, suffer from chronic hepatitis B and face a 30%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac7d49c4f695d61dbaa1fb987f91f49
https://doi.org/10.1517/13543784.12.8.1281
https://doi.org/10.1517/13543784.12.8.1281
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:3200-3208
The guanosine analogs BMS-200475 and lobucavir have previously been shown to effectively suppress propagation of the human hepatitis B virus (HBV) and woodchuck hepatitis virus (WHV) in 2.2.15 liver cells and in the woodchuck animal model system, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb283e6894c43f904fc70036ed9d5e
https://doi.org/10.1128/aac.42.12.3200
https://doi.org/10.1128/aac.42.12.3200
Autor:
David Y. Li, Kanda S. Ramasamy, Esmir Gunic, Zhi Hong, Anneke Raney, Jingfan Huang, Suetying Chow, Jean-Luc Girardet, Frank Rong, Robert K. Hamatake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2456-2458
A series of 6-hydrazinopurine 2'-methyl ribonucleosides was synthesized and tested for its inhibitory activity against the hepatitis C virus (HCV). The lack of antiviral activity of these nucleosides was associated with a poor affinity for adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97716794e17762d787b5252296f2b4ad
https://doi.org/10.1016/j.bmcl.2007.02.029
https://doi.org/10.1016/j.bmcl.2007.02.029
Publikováno v:
Journal of Virology. 72:2765-2776
The double-stranded DNA genome of human hepatitis B virus (HBV) and related hepadnaviruses is reverse transcribed from a pregenomic RNA by a viral polymerase (Pol) harboring both priming and RNA- and DNA-dependent elongation activities. Although hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a64d7121d2232558e33f0a59fd3d18
https://doi.org/10.1128/jvi.72.4.2765-2776.1998
https://doi.org/10.1128/jvi.72.4.2765-2776.1998
Publikováno v:
Journal of General Virology. 78:857-865
The herpes simplex virus type 1 (HSV) single-stranded DNA-binding protein (SSB, ICP8) stimulates the viral DNA polymerase (Pol) on an oligonucleotide-primed single-stranded DNA template. This stimulation is non-specific since other SSBs also increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55f38b4b1872406dc8fff0b072c23b9
https://doi.org/10.1099/0022-1317-78-4-857
https://doi.org/10.1099/0022-1317-78-4-857
Autor:
David Standring, Robert K. Hamatake, Sharon Zhang, Hwei-Gene Heidi Wang, Dennis Hernandez, James Alan Butcher, Gwendelíne Clark, Marc Bifano, Richard J. Colonno, Jason Racela
Publikováno v:
Intervirology. 39:249-258
An in vitro cleavage system was established to measure HCV NS3 protease trans -processing activity. This system utilizes purified NS3-4A protein from baculovirus, purified substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f37226769c3eb79b60d37304d98d59f
https://doi.org/10.1159/000150525
https://doi.org/10.1159/000150525