Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert K. Dingman"'
Autor:
Nhan H. Nguyen, Fiona Y. Glassman, Robert K. Dingman, Gautam N. Shenoy, Elizabeth A. Wohlfert, Jason G. Kay, Richard B. Bankert, Sathy V. Balu-Iyer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The safety and efficacy of several life-saving therapeutic proteins are compromised due to their immunogenicity. Once a sustained immune response against a protein-based therapy is established, clinical options that are safe and cost-effecti
Externí odkaz:
https://doaj.org/article/1786baa1e47743e4a012fbcf4ceadcfd
Publikováno v:
J Thromb Haemost
Background The development of anti-drug antibodies, also termed inhibitors, against administered Factor FVIII (FVIII) is one of the major complications in the clinical management of Hemophilia A. Once formed, these inhibitory antibodies abrogate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c255e4be17be9ce33734bfd8d408cce0
https://doi.org/10.1111/jth.15497
https://doi.org/10.1111/jth.15497
Publikováno v:
Immunol Invest
Phosphatidylserine (PS) is a naturally occurring anionic phospholipid that is primarily located in the inner leaflet of eukaryotic cell membranes. The role of PS during apoptosis is one of the most studied biological functions of PS. Externalization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87be02940855ec91a410003650453e18
https://doi.org/10.1080/08820139.2020.1738456
https://doi.org/10.1080/08820139.2020.1738456
Autor:
Elizabeth A. Wohlfert, Nhan H. Nguyen, Fiona Y. Glassman, Gautam N Shenoy, Sathy V. Balu-Iyer, Robert K. Dingman, Richard B. Bankert, Jason G. Kay
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The safety and efficacy of several life-saving therapeutic proteins are compromised due to their immunogenicity. Once a sustained immune response against a protein-based therapy is established, clinical options that are safe and cost-effective become
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a401eb8a90634c902be93441a8fa3683
https://doi.org/10.1038/s41598-021-97333-0
https://doi.org/10.1038/s41598-021-97333-0
Autor:
Sathy V. Balu-Iyer, Robert K. Dingman
Publikováno v:
J Pharm Sci
Protein therapeutics have drastically changed the landscape of treatment for many diseases by providing a regimen that is highly specific and lacks many off target toxicities. The clinical utility of many therapeutic proteins has been undermined by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc7c451d701dd58284431e16de310e7
https://doi.org/10.1016/j.xphs.2018.12.014
https://doi.org/10.1016/j.xphs.2018.12.014
Autor:
Radha Ramakrishnan, Jennifer L. Schneider, Robert K. Dingman, Murali Ramanathan, Fiona Y. Glassman, Sathy V. Balu-Iyer, Richard B. Bankert
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2048-2054
Phosphatidylserine (PS) exposure during apoptosis leads to silent clearance of cells without adverse immune reactions to self-proteins. Given the biological functions of PS in cellular cleanup and global immunosuppression, we hypothesized that admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3177f34fce51fe7555a6d66eaa3ef39e
https://doi.org/10.1016/j.xphs.2018.03.027
https://doi.org/10.1016/j.xphs.2018.03.027
Publikováno v:
Journal of Pharmaceutical Sciences. 107:831-837
Enzyme replacement therapy with recombinant human acid α-glucosidase (rhGAA) is complicated by the formation of anti-rhGAA antibodies, a short circulating half-life, instability in the plasma, and limited uptake into target tissue. Previously, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986d9a90eae3be700013328f846663b0
https://doi.org/10.1016/j.xphs.2017.10.038
https://doi.org/10.1016/j.xphs.2017.10.038
Autor:
Sarah H. Hayes, Joan S. Baizer, Dalian Ding, Senthilvelan Manohar, Richard Salvi, Robert K. Dingman, Keit Men Wong
Publikováno v:
Neuroscience. 303:299-311
Exposure to loud, prolonged sounds (acoustic trauma, AT) leads to the death of both inner and outer hair cells (IHCs and OHCs), death of neurons of the spiral ganglion and degeneration of the auditory nerve. The auditory nerve (8cn) projects to the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154f75300b3659932daf66c1d6fc451c
https://doi.org/10.1016/j.neuroscience.2015.07.004
https://doi.org/10.1016/j.neuroscience.2015.07.004