Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert K. Delisle"'
Autor:
Robert DeLisle, David Diller
Publikováno v:
Current Computer Aided-Drug Design. 5:69-70
Autor:
Joseph Yang, Edward N. Brody, Ashwin C. Murthy, Robert E. Mehler, Sophie J. Weiss, Robert K. DeLisle, Rachel Ostroff, Stephen A. Williams, Peter Ganz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 15 (2020)
Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart diseas
Externí odkaz:
https://doaj.org/article/f83d4b28db5b4ae185992624b9f7d669
Autor:
DeLisle, Robert, Diller, David
Publikováno v:
Current Computer - Aided Drug Design; June 2009, Vol. 5 Issue: 2 p69-70, 2p
Publikováno v:
Chemical Research in Toxicology. 22:1298-1309
Gemfibrozil-1-O-beta-glucuronide (GEM-1-O-gluc), a major metabolite of the antihyperlipidemic drug gemfibrozil, is a mechanism-based inhibitor of P450 2C8 in vitro, and this irreversible inactivation may lead to clinical drug-drug interactions betwee
Publikováno v:
Journal of Molecular Graphics and Modelling. 20:155-167
Estrogen is a steroid hormone playing critical roles in physiological processes such as sexual differentiation and development, female and male reproductive processes, and bone health. Numerous natural and synthetic environmental compounds have been
Publikováno v:
Journal of Biological Chemistry. 274:14352-14358
A ligand-inducible transactivation function (AF-2) exists in the extreme carboxyl terminus of the vitamin D receptor (VDR) that is essential for 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3)-activated transcription and p160 coactivator interaction. Cr
Publikováno v:
Journal of Biological Chemistry. 270:4748-4752
The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription. However, the mechanism of transcriptio
Publikováno v:
Chemical research in toxicology. 16(12)
In the present study, values of the binding energy (BE) were calculated for the rat androgen receptor on a data set of 25 steroidal and nonsteroidal compounds for which published values of the observed binding affinity (K(i)) are available. A correla
Autor:
Ann M. Richard, Kevin W. Gaido, Robert K DeLisle, Hiromichi Yoshikawa, William J. Welsh, Susan M Ross, Hiroto Tamura
Publikováno v:
Environmental Health Perspectives
Identification of several environmental chemicals capable of binding to the androgen receptor (AR) and interfering with its normal function has heightened concern about adverse effects across a broad spectrum of environmental chemicals. We previously
Publikováno v:
Stroke. 27(1)
Background and Purpose We have previously shown that traumatic injury of hippocampal cells triggers release of a soluble neurotoxin that can be transferred to an uninjured culture. The mechanism of this trauma-induced neurotoxicity is independent of