Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Robert K. Kan"'
Publikováno v:
Annals of the New York Academy of Sciences. 1374:68-77
The current research progression efforts for investigating novel treatments for exposure to organophosphorus (OP) compounds that inhibit acetylcholinesterase (AChE), including pesticides and chemical warfare nerve agents (CWNAs), rely solely on in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea6c9243f83404541e479590187a0bba
https://doi.org/10.1111/nyas.13051
https://doi.org/10.1111/nyas.13051
Autor:
Jessica A. Leuschner, Michael W. Perkins, Thuy T. Dao, Robert K. Kan, Alfred M. Sciuto, Ashley Rodriguez, Jennifer L. Devorak, Benjamin Wong
Publikováno v:
Inhalation Toxicology. 28:14-21
Neurological toxicity and brain injury following vapor inhalation exposure to the chemical warfare nerve agent (CWNA) soman (GD) were examined in untreated non-anesthetized rats. In this study, male Sprague-Dawley rats (300-350 g) were exposed to 600
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e291ef3214ad8c4ab4d7410c8f88e36
https://doi.org/10.3109/08958378.2015.1125973
https://doi.org/10.3109/08958378.2015.1125973
Publikováno v:
Neurotoxicology. 58
Organophosphate compounds, such as soman and sarin, are highly toxic chemical warfare nerve agents that cause a build-up of acetylcholine in synapses and neuromuscular junctions. Current therapies aim to prevent seizures and protect against brain inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d940269a78ac3ff85d4fdd1b43da3af
https://pubmed.ncbi.nlm.nih.gov/27988303
https://pubmed.ncbi.nlm.nih.gov/27988303
Publikováno v:
Annals of the New York Academy of Sciences. 1374(1)
The current research progression efforts for investigating novel treatments for exposure to organophosphorus (OP) compounds that inhibit acetylcholinesterase (AChE), including pesticides and chemical warfare nerve agents (CWNAs), rely solely on in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb4f47dead8cf2e3b97674602038e624
https://pubmed.ncbi.nlm.nih.gov/27123828
https://pubmed.ncbi.nlm.nih.gov/27123828
Publikováno v:
Journal of Inflammation (London, England)
Background Status epilepticus (SE) can cause neuronal cell death and impaired behavioral function. Acute exposure to potent acetylcholinesterase inhibitors such as soman (GD) can cause prolonged SE activity, micro-hemorrhage and cell death in the hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b922506d4623b0b3127649ca160dcb
http://europepmc.org/articles/PMC4510912
http://europepmc.org/articles/PMC4510912
Autor:
Robert K. Kan, Edna F. R. Pereira, William P. Fawcett, Yasco Aracava, William R. Randall, Edson X. Albuquerque, Tracey A. Hamilton, Michael Adler, Maristela Oliveira, James A. Romano
Publikováno v:
Proceedings of the National Academy of Sciences. 103:13220-13225
The nerve agents soman, sarin, VX, and tabun are deadly organophosphorus (OP) compounds chemically related to OP insecticides. Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b22f7af3f76e40a4b79d365e841c2e
https://doi.org/10.1073/pnas.0605370103
https://doi.org/10.1073/pnas.0605370103
Autor:
Charlene M. Corun, Robert K. Kan, Carmen M. Arroyo, Marian R. Nelson, Juanita J. Guzman, David W. Kahler, Clarence A. Broomfield, Damon L. Burman
Publikováno v:
Pharmacology & Toxicology. 92:204-213
The regulatory effects of the active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D3 (1-alpha, 25 (OH)2D3) were assessed on the cytokine and chemokine secretion induced by sulfur mustard on human skin fibroblasts and human epidermal keratinocytes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::169587be06f97d10bec20fa245017118
https://doi.org/10.1034/j.1600-0773.2003.920503.x
https://doi.org/10.1034/j.1600-0773.2003.920503.x
Publikováno v:
Toxicologic Pathology. 31:185-190
The present study was aimed to examine whether apoptosis is involved in the pathogenesis of sulfur mustard (SM)-induced basal cell death. Skin sites of the hairless guinea pig exposed to SM vapor for 8 minutes were harvested at 3, 6, 12, 24, and 48 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37db369f94eb2207b8c952b1ffab909
https://doi.org/10.1080/01926230390183661
https://doi.org/10.1080/01926230390183661
Publikováno v:
Microscopy Research and Technique. 54:246-253
Frozen skin sections are routinely used for light microscopic immunohistochemical study of the skin basement membrane zone for two reasons: some skin basement membrane zone proteins are labile to routine chemical fixation, and skin is not amenable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0648dc201edb360e79776337cc50da77
https://doi.org/10.1002/jemt.1136
https://doi.org/10.1002/jemt.1136
Publikováno v:
NeuroReport. 7:2691-2694
The goal of this study was to evaluate the effects of microwave irradiation on immunocytochemical staining in freshly frozen rat brain tissue using an antibody previously shown to successfully stain only formalin-fixed materials. GFAP immunoreactivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd2f30c390097afa2802de18107a9cb
https://doi.org/10.1097/00001756-199611040-00057
https://doi.org/10.1097/00001756-199611040-00057