Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Robert K Y, Cheng"'
Autor:
Tobias Claff, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Renato H. Weiße, Robert K. Y. Cheng, Sandra Markovic-Mueller, Denis Bucher, Norbert Sträter, Christa E. Müller
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The Gs protein-coupled adenosine A2A receptor (A2AAR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was developed as an A2AAR antagonist with ancillary blockade of the A2BAR subtype. It cons
Externí odkaz:
https://doaj.org/article/be5089b2d60c4f06bb110f0f415664ab
Autor:
Mathieu Botte, Dongchun Ni, Stephan Schenck, Iwan Zimmermann, Mohamed Chami, Nicolas Bocquet, Pascal Egloff, Denis Bucher, Matilde Trabuco, Robert K. Y. Cheng, Janine D. Brunner, Markus A. Seeger, Henning Stahlberg, Michael Hennig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Lateral opening of the LptDE transporter in the outer membrane of Gram-negative bacteria is necessary for insertion of lipopolysaccharides. Here, Botte et al. report a cryo-EM structure of a partially opened LptDE transporter, in complex with rigid c
Externí odkaz:
https://doaj.org/article/25e3d626c5e9434d8732b67049815a5b
Autor:
Camila Bacellar, Filip Leonarski, Ivan Usov, Shahrooz Nasrollahi Shirazi, Petr Skopintsev, Karol Nass, Dmitry Ozerov, Natacha Olieric, Michael Hennig, Tobias Weinert, Aldo Mozzanica, Christopher J. Milne, Florian S. N. Dworkowski, T. Geng, Gregor Knopp, M. Sharpe, S. Redford, Claudio Cirelli, Rafael Abela, R. Bohinc, Isabelle Martiel, Andrew S. Doré, Gebhard F. X. Schertler, Przemyslaw Nogly, Robert K. Y. Cheng, Daniel James, Luc Patthey, Michel O. Steinmetz, Shibom Basu, Laura Vera, Mathieu Rappas, C. Casadei, Robert M. Cooke, Jörg Standfuss, Meitian Wang, Bernd Schmitt
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 965-975 (2020)
IUCrJ, 7 (6)
IUCrJ
IUCrJ, 7 (6)
IUCrJ
Long-wavelength pulses from the Swiss X-ray free-electron laser (XFEL) have been used for de novo protein structure determination by native single-wavelength anomalous diffraction (native-SAD) phasing of serial femtosecond crystallography (SFX) data.
Publikováno v:
The FEBS Journal. 287:866-873
The in meso in situ serial X-ray crystallization method (Huang et al., (2015) Acta Crystallogr D Biol Crystallogr 71, 1238) combines lipid cubic phase crystallization, direct freezing of the crystallization droplet without handling of the crystals, a
Autor:
Huber S, Abdul Rahman W, Denis Bucher, Mohamed Chami, Tagmose L, Robert K. Y. Cheng, Michael Hennig, Rodríguez D, Julie K. Klint, Mathieu Botte
Kv3 ion-channels constitute a class of functionally distinct voltage gated ion channels characterized by their ability to fire at a high frequency. Several disease relevant mutants, together with biological data, suggest the importance of this class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eda74961852e4f0006be007312ce651
https://doi.org/10.1101/2021.07.13.452180
https://doi.org/10.1101/2021.07.13.452180
Autor:
Tasia, Amelia, Jacobus P D, van Veldhoven, Matteo, Falsini, Rongfang, Liu, Laura H, Heitman, Gerard J P, van Westen, Elena, Segala, Grégory, Verdon, Robert K Y, Cheng, Robert M, Cooke, Daan, van der Es, Adriaan P, IJzerman
Publikováno v:
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Autor:
Tasia Amelia, Robert K. Y. Cheng, Gerard J. P. van Westen, Rongfang Liu, Elena Segala, Robert M. Cooke, Laura H. Heitman, Jacobus P. D. van Veldhoven, Daan van der Es, Matteo Falsini, Grégory Verdon, Adriaan P. IJzerman
Publikováno v:
Journal of Medicinal Chemistry, 64(7), 3827-3842. American Chemical Society (ACS)
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eaee9ee24339f7b4772a78e3323223
http://hdl.handle.net/1887/3204468
http://hdl.handle.net/1887/3204468
Autor:
Robert K. Y. Cheng, Mohamed Chami, Matilde Cardoso Trabuco, Stephan Schenck, Janine D. Brunner, Henning Stahlberg, Michael Hennig, Denis Bucher, Markus A. Seeger, Pascal Egloff, Nicolas Bocquet, Iwan Zimmermann, Mathieu Botte, Dongchun Ni
Lipopolysaccharides (LPS) are major constituents of the extracellular leaflet in the bacterial outer membrane and form an effective physical barrier for environmental threats and for antibiotics in Gram-negative bacteria 1. The last step of LPS inser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4301c1aaeea1a661029ab33ce3c58b2
https://doi.org/10.1101/2021.03.23.436624
https://doi.org/10.1101/2021.03.23.436624
Autor:
Louis Leong, Benjamin Tehan, Dean G. Brown, Dawn M. Troast, Giles A. Brown, Nils-Olov Hermansson, Peter E. Thornton, Cédric Fiez-Vandal, Holly H. Soutter, Oliver Schlenker, Fiona H. Marshall, Robert M. Cooke, Arjan Snijder, Karl Edman, Christoph Grebner, Giselle R. Wiggin, A.S. Dore, Stefan Geschwindner, Andrei Zhukov, Birte Aggeler, Christoph E. Dumelin, Niek Dekker, Patrik Johansson, Robert K. Y. Cheng, Mathieu Rappas, Ali Jazayeri, Linda Sundström, Rudi Prihandoko
Publikováno v:
Nature. 545:112-115
Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug desi
Autor:
Andrew S. Doré, James C. Errey, Laura H. Heitman, Adriaan P. IJzerman, Fiona H. Marshall, Elena Segala, Francesca Deflorian, Robert M. Cooke, Dong Guo, Robert K. Y. Cheng, Andrea Bortolato
Publikováno v:
Journal of Medicinal Chemistry, 59(13), 6470-6479
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge StrengthElena Segala, Dong Guo, Robert K. Y. Cheng, Andrea Bortolato, Francesca Deflorian, Andrew S. Doré, James C. Errey, Laura H. Heitman, Ad