Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Robert K Winn"'
Autor:
Akiko Iwata, R Angelo de Claro, Vicki L Morgan-Stevenson, Joan C Tupper, Barbara R Schwartz, Li Liu, Xiaodong Zhu, Katherine C Jordan, Robert K Winn, John M Harlan
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14729 (2011)
Severe sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic manipulation of death and survival pathways has been shown to modulate organ
Externí odkaz:
https://doaj.org/article/3763326c217a4beda13f907baf8de85f
Autor:
Robert K. Winn, Jennifer Blackwood, Michael L. Morrison, Akiko Iwata, Summer L. Lockett, Mark B. Roth
Publikováno v:
Journal of Trauma: Injury, Infection & Critical Care. 65:183-188
Background: Reduced metabolic activity improves outcome in many clinical and experimental models of injury and diseases that result in insufficient blood supply. Recently, we demonstrated that inhaled hydrogen sulfide gas can be used to reversibly re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a0c05caa9cf1fdf27ed5e06078a8c4
https://doi.org/10.1097/ta.0b013e3181507579
https://doi.org/10.1097/ta.0b013e3181507579
Autor:
Gary J. Vanasse, Robert K. Winn, Sofya Rodov, Arthur W. Zieske, John T. Li, Joan C. Tupper, Jingjing Tang, Elaine W. Raines, Mette A. Peters, Ka Yee Yeung, John M. Harlan
Publikováno v:
Molecular Cancer Research. 2:620-631
The t(14;18)(q32;q21), resulting in deregulated expression of B-cell-leukemia/lymphoma-2 (Bcl-2), represents the genetic hallmark in human follicular lymphomas. Substantial evidence supports the hypothesis that the t(14;18) and Bcl-2 overexpression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d73742113ed828ca2e9222f866bf3816
https://doi.org/10.1158/1541-7786.620.2.11
https://doi.org/10.1158/1541-7786.620.2.11
Publikováno v:
Clinical and Vaccine Immunology. 11:358-361
To determine whether the Fas/Fas ligand (FasL) (CD95/CD178) system contributes to the development of an inflammatory response in vivo, 2.5 μg of bacterial lipopolysaccharide (LPS; endotoxin) per g was administered intranasally to healthy mice (C57BL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d757b80498ab660c6035444fc7cb3ff
https://doi.org/10.1128/cdli.11.2.358-361.2004
https://doi.org/10.1128/cdli.11.2.358-361.2004
Autor:
Annie Minard, John M. Harlan, Michael Tasch, Vicki Morgan Stevenson, Robert K. Winn, Eric Lagasse, Irving L. Weissman, Joan C. Tupper, Akiko Iwata
Publikováno v:
The Journal of Immunology. 171:3136-3141
Transgenic mice that over-express B cell leukemia/lymphomas (Bcl)-2 in myeloid cells under control of the human MRP8 promoter (hMRP8-Bcl-2) or in T lymphocytes under the Eμ promoter (Eμ-Bcl-2) were compared with C57BL/6 control mice following cecal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5f164eb5cfe9d2c17360a2c83362ee
https://doi.org/10.4049/jimmunol.171.6.3136
https://doi.org/10.4049/jimmunol.171.6.3136
Autor:
Kristine T. Eiting, John M. Harlan, Ryan D. Erwert, Robert K. Winn, Joan C. Tupper, Douglas D. Bannerman
Publikováno v:
Microbial Pathogenesis. 35:87-93
Shiga toxin (Stx) has been implicated in the pathogenesis of several human and animal disease states. A key host target of Stx is the endothelial cell. Stx induces endothelial cell apoptosis through a mechanism that remains unknown. In the present re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a76850b7e1942307483aff2ba7199f7
https://doi.org/10.1016/s0882-4010(03)00100-1
https://doi.org/10.1016/s0882-4010(03)00100-1
Autor:
Robert K. Winn, Joan C. Tupper, John M. Harlan, Douglas D. Bannerman, Christopher J. Rhodes, Xianwu Li
Publikováno v:
Infection and Immunity. 71:4414-4420
Many of the proinflammatory effects of gram-negative bacteria are elicited by the interaction of bacterial lipopolysaccharide (LPS) with Toll-like receptor 4 (TLR4) expressed on host cells. TLR4 signaling leads to activation of NF-kappa B and transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c288f40ec4712e025ef122f05670055
https://doi.org/10.1128/iai.71.8.4414-4420.2003
https://doi.org/10.1128/iai.71.8.4414-4420.2003
Autor:
John M. Harlan, Emil Y. Chi, Akiko Iwata, Robert K. Winn, Kazumi Nishio, William R. Henderson
Publikováno v:
The Journal of Immunology. 170:3386-3391
Asthma is characterized by acute and chronic airway inflammation, and the severity of the airway hyperreactivity correlates with the degree of inflammation. Many of the features of lung inflammation observed in human asthma are reproduced in OVA-sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6bd72702847c63f0335825c0ecb0b1
https://doi.org/10.4049/jimmunol.170.6.3386
https://doi.org/10.4049/jimmunol.170.6.3386
Autor:
Peter I. Chuang, Akihiro Takemasa, Mechthild Jonas, Richard B. Goodman, Emil Y. Chi, Henry Rosen, Chien Ying Liu, John M. Harlan, W. Conrad Liles, Robert K. Winn
Publikováno v:
Blood. 101:295-304
It is increasingly clear that there are caspase-dependent and -independent mechanisms for the execution of cell death and that the utilization of these mechanisms is stimulus- and cell type–dependent. Intriguingly, broad-spectrum caspase inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145a200565529ca3df3b8e5a781e7ba5
https://doi.org/10.1182/blood-2001-12-0266
https://doi.org/10.1182/blood-2001-12-0266
Publikováno v:
Journal of Biological Chemistry. 277:40567-40574
Shiga-like toxin (SLT) has been implicated in the pathogenesis of hemolytic uremic syndrome and its attendant endothelial cell (EC) injury. Key serotypes of Escherichia coli produce SLT-1 in addition to another highly pro-inflammatory molecule, lipop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff90f3ff735f2cfb8870acc7b5b3b52
https://doi.org/10.1074/jbc.m206351200
https://doi.org/10.1074/jbc.m206351200