Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Robert K Slany"'
Autor:
Mark W Woodcroft, Kyster Nanan, Patrick Thompson, Kathrin Tyryshkin, Steven P Smith, Robert K Slany, David P LeBrun
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130495 (2015)
The oncogenic transcription factor E2A-PBX1 is expressed consequent to chromosomal translocation 1;19 and is an important oncogenic driver in cases of pre-B-cell acute lymphoblastic leukemia (ALL). Elucidating the mechanism by which E2A-PBX1 induces
Externí odkaz:
https://doaj.org/article/7be363071c184585bc50365321ce26f1
Autor:
Elisa Fueller, Daniel Schaefer, Ute Fischer, Pina F I Krell, Martin Stanulla, Arndt Borkhardt, Robert K Slany
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104419 (2014)
Here we present a novel method "Genomic inverse PCR for exploration of ligated breakpoints" (GIPFEL) that allows the sensitive detection of recurrent chromosomal translocations. This technique utilizes limited amounts of DNA as starting material and
Externí odkaz:
https://doaj.org/article/3d4cc45907f54ec5a6b662c4c46a50c6
Autor:
Dorothee Mueller, María-Paz García-Cuéllar, Christian Bach, Sebastian Buhl, Emanuel Maethner, Robert K Slany
Publikováno v:
PLoS Biology, Vol 7, Iss 11, p e1000249 (2009)
Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of t
Externí odkaz:
https://doaj.org/article/c4ba390ee4a744468d14a2da8c848935
Autor:
Robert K. Slany
Publikováno v:
HemaSphere, Vol 8, Iss 6, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/f43f450431674e1b97044b890c83e339
Publikováno v:
Haematologica, Vol 107, Iss 11 (2022)
The homeobox transcription factors HoxA9 and Meis1 are causally involved in the etiology of acute myeloid leukemia. While HoxA9 alone immortalizes cells, cooperation with Meis1 is necessary to induce a full leukemic phenotype. Here, we applied degron
Externí odkaz:
https://doaj.org/article/d2eb23fd7bc34c579de763c832e3950f
Autor:
Amit Sharma, Nidhi Jyotsana, Razif Gabdoulline, Dirk Heckl, Florian Kuchenbauer, Robert K. Slany, Arnold Ganser, Michael Heuser
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearran
Externí odkaz:
https://doaj.org/article/2c4504fcbbc6476ebb3bdac800d86d4d
The transcription factor CCAAT-enhancer binding factor alpha (C/ebpα) is a master controller of myeloid differentiation that is expressed as long (p42) and short (p30) isoform. Mutations within theCEBPAgene selectively deleting p42 are frequent in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f61842cae4d08eba764d8e0cb004f769
https://doi.org/10.1101/2023.05.16.540903
https://doi.org/10.1101/2023.05.16.540903
Autor:
Jay L. Hess, Robert K. Slany, Thomas A. Milne, Mohamad El-Osta, Zhaohai Yang, Corrado Caslini
Supplementary Figure 5 from Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ef77fb268334ded9381887f75d327a
https://doi.org/10.1158/0008-5472.22365705
https://doi.org/10.1158/0008-5472.22365705
Supplementary Methods from Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188ab8a0b2751d25a077c095344f37e1
https://doi.org/10.1158/0008-5472.22364442.v1
https://doi.org/10.1158/0008-5472.22364442.v1
Supplementary Figure 2 from Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215ec5c58ed75be5174294ec65bba135
https://doi.org/10.1158/0008-5472.22364445.v1
https://doi.org/10.1158/0008-5472.22364445.v1