Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Robert K, Ernst"'
Autor:
Ruchika Dehinwal, Tata Gopinath, Richard D. Smith, Robert K. Ernst, Dieter M. Schifferli, Matthew K. Waldor, Francesca M. Marassi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have key roles in cell envelope homeostasis, secretion, interbacterial communication, and pathogenesis. The facultative intracellular pathogen Salmonella Typhimurium increases
Externí odkaz:
https://doaj.org/article/0b2fa93830f14e3a9591beec10a5f1a1
Autor:
Shirin Ghods, Artur Muszyński, Hyojik Yang, Ratnam S. Seelan, Asal Mohammadi, Jacob S. Hilson, Griffin Keiser, Frank C. Nichols, Parastoo Azadi, Robert K. Ernst, Fata Moradali
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundThis study unveils the intricate functional association between cyclic di-3’,5’-adenylic acid (c-di-AMP) signaling, cellular bioenergetics, and the regulation of lipopolysaccharide (LPS) profile in Porphyromonas gingivalis, a Gram-negat
Externí odkaz:
https://doaj.org/article/1015e19a0cc64c33918977091768a1d6
Autor:
Debaki R. Howlader, Rahul Shubhra Mandal, Ti Lu, Suhrid Maiti, Zackary K. Dietz, Sayan Das, Sean K. Whittier, Aaron C. Nagel, Satabdi Biswas, David J. Varisco, Francesca M. Gardner, Robert K. Ernst, William D. Picking, Wendy L. Picking
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pseudomonas aeruginosa (Pa) is an opportunistic bacterial pathogen responsible for severe hospital acquired infections in immunocompromised and elderly individuals. Emergence of increasingly drug resistant strains and the absence of a broad-spectrum
Externí odkaz:
https://doaj.org/article/045977411a494c21b6ddb2526b664939
Autor:
Ti Lu, Murugesan Raju, Debaki R. Howlader, Zackary K. Dietz, Sean K. Whittier, David J. Varisco, Robert K. Ernst, Lyndon M. Coghill, William D. Picking, Wendy L. Picking
Publikováno v:
Vaccines, Vol 12, Iss 6, p 618 (2024)
Shigella spp. are responsible for bacillary dysentery or shigellosis transmitted via the fecal–oral route, causing significant morbidity and mortality, especially among vulnerable populations. There are currently no licensed Shigella vaccines. Shig
Externí odkaz:
https://doaj.org/article/c3f8050c393a4aa7b5ff75c873148e6a
Autor:
Hyojik Yang, Victoria I. Verhoeve, Courtney E. Chandler, Shreeram Nallar, Greg A. Snyder, Robert K. Ernst, Joseph J. Gillespie
Publikováno v:
mSphere, Vol 9, Iss 2 (2024)
ABSTRACT Rickettsiae are Gram-negative obligate intracellular parasites of numerous eukaryotes. Human pathogens of the transitional group (TRG), typhus group (TG), and spotted fever group (SFG) rickettsiae infect blood-feeding arthropods, have dissim
Externí odkaz:
https://doaj.org/article/3211a0956409418ebdd41ac52a168d26
Autor:
Casey E. Hofstaedter, Courtney E. Chandler, Charles M. Met, Joseph J. Gillespie, Janette M. Harro, David R. Goodlett, David A. Rasko, Robert K. Ernst
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Pseudomonas aeruginosa can survive in a myriad of environments, partially due to modifications of its lipid A, the membrane anchor of lipopolysaccharide. We previously demonstrated that divergent late acyltransferase paralogs, HtrB1 and HtrB
Externí odkaz:
https://doaj.org/article/ea0cd43ff14a45149c62cd93f51dc5bd
Publikováno v:
mSystems, Vol 8, Iss 6 (2023)
ABSTRACT Spatially aware de novo discovery methods are essential tools for therapeutic target identification in complex interphylum interactions such as arthropods and mammals. Notably, the methods should ideally be species agnostic, showing unique f
Externí odkaz:
https://doaj.org/article/a74d2a0a179f472585bfc8fdd1672839
Autor:
Debaki R. Howlader, Sayan Das, Ti Lu, Rahul Shubhra Mandal, Gang Hu, David J. Varisco, Zackary K. Dietz, Siva Sai Kumar Ratnakaram, Robert K. Ernst, William D. Picking, Wendy L. Picking
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract The opportunistic pathogen Pseudomonas aeruginosa (Pa) causes severe nosocomial infections, especially in immunocompromised individuals and the elderly. Increasing drug resistance, the absence of a licensed vaccine and increased hospitalizat
Externí odkaz:
https://doaj.org/article/5bfaa7830aeb4108a21734bbcc9aa1d3
Autor:
Ti Lu, Sayan Das, Debaki R. Howlader, Akshay Jain, Gang Hu, Zackary K. Dietz, Qi Zheng, Siva Sai Kumar Ratnakaram, Sean K. Whittier, David J. Varisco, Robert K. Ernst, William D. Picking, Wendy L. Picking
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of 90 million cases annually. Despite the severity of this disease, there is currently no licensed vaccine against shigellosis. Shigella’s primary viru
Externí odkaz:
https://doaj.org/article/96e7e423772c4f73a7467c187bacfbb4
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107700- (2023)
Summary: Pseudomonas aeruginosa (Pa) is a pathogen causing chronic pulmonary infections in patients with cystic fibrosis (CF). Manipulation of lipids is an important feature of Pa infection and on a tissue-level scale is poorly understood. Using a mo
Externí odkaz:
https://doaj.org/article/6841bbb428754b1087f74c541df45547