Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Robert Jordan"'
Autor:
Mariana F. Tioni, Robert Jordan, Angie Silva Pena, Aditya Garg, Danlu Wu, Shannon I. Phan, Christopher M. Weiss, Xing Cheng, Jack Greenhouse, Tatyana Orekov, Daniel Valentin, Swagata Kar, Laurent Pessaint, Hanne Andersen, Christopher C. Stobart, Melissa H. Bloodworth, R. Stokes Peebles, Yang Liu, Xuping Xie, Pei-Yong Shi, Martin L. Moore, Roderick S. Tang
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA virus that relies on its trimeric surface glycoprotein spike for entry into host cells. Here
Externí odkaz:
https://doaj.org/article/87b82e0844a44499a2c4b6faecce72a2
Autor:
John Dodd, Robert Jordan, Marie Makhlina, Keith Barnett, Ad Roffel, Carl Spana, Alison Obr, Priyanka Dhingra, Paul S. Kayne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel, polymer-enc
Externí odkaz:
https://doaj.org/article/6822292f0ed94f7caf82349ccec80548
Autor:
Marzia Rizzo, Natthapon Soisangwan, Samuel Vega-Estevez, Robert Jordan Price, Chloe Uyl, Elise Iracane, Matt Shaw, Jan Soetaert, Anna Selmecki, Alessia Buscaino
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010576 (2022)
A delicate balance between genome stability and instability ensures genome integrity while generating genetic diversity, a critical step for evolution. Indeed, while excessive genome instability is harmful, moderated genome instability can drive adap
Externí odkaz:
https://doaj.org/article/6f087a8c81da454491eb47dc356da5c0
Autor:
Leonard R. Derogatis, Dennis A. Revicki, Raymond C. Rosen, Robert Jordan, Johna Lucas, Carl Spana
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract Background For the treatment of female sexual dysfunction, the most relevant outcome measures are patient-reported treatment effects and changes in symptoms, underscoring the need for reliable, validated patient-reported outcome (PRO) instru
Externí odkaz:
https://doaj.org/article/dcf5a532b3e041958decfa5d98b83316
Autor:
Dennis A. Revicki, Stanley E. Althof, Leonard R. Derogatis, Sheryl A. Kingsberg, Hilary Wilson, Amama Sadiq, Julie Krop, Robert Jordan, Johna Lucas
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 4, Iss 1, Pp 1-11 (2020)
Abstract Background The Elements of Desire Questionnaire (EDQ) is a patient-reported outcome (PRO) measure developed to evaluate sexual desire and was included in two identically designed phase 3 clinical trials (RECONNECT) as an exploratory endpoint
Externí odkaz:
https://doaj.org/article/3f8451fc538e4ffea364dd0a3c4f6011
Autor:
Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination ther
Externí odkaz:
https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Eukaryotic genomes are packaged into chromatin structures that play pivotal roles in regulating all DNA-associated processes. Histone posttranslational modifications modulate chromatin structure and function, leading to rapid regulation of g
Externí odkaz:
https://doaj.org/article/0e94037294e0404bafe7fa0e40958e8e
Autor:
Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity. We recently
Externí odkaz:
https://doaj.org/article/1b011f9fd4ae445884489fb5ef613ee9
Autor:
Hualan Liu, Morgan N. Price, Robert Jordan Waters, Jayashree Ray, Hans K. Carlson, Jacob S. Lamson, Romy Chakraborty, Adam P. Arkin, Adam M. Deutschbauer
Publikováno v:
mSystems, Vol 3, Iss 1 (2018)
ABSTRACT Transposon mutagenesis coupled to next-generation sequencing (TnSeq) is a powerful approach for discovering the functions of bacterial genes. However, the development of a suitable TnSeq strategy for a given bacterium can be costly and time-
Externí odkaz:
https://doaj.org/article/7bfe5283e96d4fcdb721b110a8e98eae
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Centromeres, sites of kinetochore assembly, are important for chromosome stability and integrity. Most eukaryotes have regional centromeres epigenetically specified by the presence of the histone H3 variant CENP-A. CENP-A chromatin is often surrounde
Externí odkaz:
https://doaj.org/article/48325cd4eaae49d09fdd9c45dabb10b0