Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robert Jenke"'
Autor:
Leoni Lorenz, Tamara Zenz, Denys Oliinyk, Florian Meier-Rosar, Robert Jenke, Achim Aigner, Thomas Büch
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1080 (2024)
Histone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical studies in various solid tumors, including gastric carcinoma; however, their use in clinical studies has not yet yielded convincing efficacies. Thus, further stu
Externí odkaz:
https://doaj.org/article/1129247439b8483c9cb26744a377bf8a
Publikováno v:
Cells, Vol 10, Iss 2, p 272 (2021)
Overexpression of members of the HER/erbB transmembrane tyrosine kinase family like HER2/erbB2/neu is associated with various cancers. Some heterodimers, especially HER2/HER3 heterodimers, are particularly potent inducers of oncogenic signaling. Stil
Externí odkaz:
https://doaj.org/article/b2ff248522ee4de781048a100abf267d
Autor:
Robert Jenke, Miriam Holzhäuser-Rein, Stefanie Mueller-Wilke, Florian Lordick, Achim Aigner, Thomas Büch
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 82 (2020)
MET-amplified gastric cancer cells are extremely sensitive to MET inhibition in vitro, whereas clinical efficacy of MET inhibitors is disappointing. The compensatory activation of other oncogenic growth factor receptors may serve as an underlying mec
Externí odkaz:
https://doaj.org/article/8622a33d508c4ed087d2b60aacbb7826
Autor:
Linda Schäker‐Hübner, Reza Haschemi, Thomas Büch, Fabian B. Kraft, Birke Brumme, Andrea Schöler, Robert Jenke, Jens Meiler, Achim Aigner, Gerd Bendas, Finn K. Hansen
Publikováno v:
ChemMedChem. 17
Herein we report the structure-activity and structure-physicochemical property relationships of a series of class I selective ortho-aminoanilides targeting the "foot-pocket" in HDAC12. To balance the structural benefits and the physicochemical disadv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719df0fdda32b3c206d20d07a15eaf64
https://doi.org/10.1002/cmdc.202100755
https://doi.org/10.1002/cmdc.202100755
Publikováno v:
Cancers
Cancers, Vol 13, Iss 634, p 634 (2021)
Cancers, Vol 13, Iss 634, p 634 (2021)
Simple Summary Beyond mutations, epigenetic changes have been described as drivers for cancer as well. While leaving the overall DNA structure intact, they can be responsible for tumor malignancy by mediating the transcriptional upregulation of oncog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0ffbbce5f8d6823c79f92dbef27e3a0e
https://ul.qucosa.de/id/qucosa:84972
https://ul.qucosa.de/id/qucosa:84972
Publikováno v:
Cells, Vol 10, Iss 272, p 272 (2021)
Cells
Volume 10
Issue 2
Cells
Volume 10
Issue 2
Overexpression of members of the HER/erbB transmembrane tyrosine kinase family like HER2/erbB2/neu is associated with various cancers. Some heterodimers, especially HER2/HER3 heterodimers, are particularly potent inducers of oncogenic signaling. Stil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9c996d3e06264eabc7b89a700d4a454f
https://ul.qucosa.de/id/qucosa:85118
https://ul.qucosa.de/id/qucosa:85118
Autor:
Thomas Büch, Florian Lordick, Achim Aigner, Stefanie Mueller-Wilke, Robert Jenke, Miriam Holzhäuser-Rein
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 82, p 82 (2021)
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 82, p 82 (2021)
MET-amplified gastric cancer cells are extremely sensitive to MET inhibition in vitro, whereas clinical efficacy of MET inhibitors is disappointing. The compensatory activation of other oncogenic growth factor receptors may serve as an underlying mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc9cc4b3ee097492e7487d50f789120
Autor:
Angelika Peer, Robert Jenke
Publikováno v:
Cognitive Systems Research. 49:128-141
Current approaches to emotion recognition do not address the fact that emotions are dynamic processes. This work concerns itself with the development of a cognitive architecture for modeling the dynamics of emotions with specific focus on a gray-box
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b60fe790dcffd050b01494b44eff8c37
https://doi.org/10.1016/j.cogsys.2018.01.004
https://doi.org/10.1016/j.cogsys.2018.01.004
Publikováno v:
IEEE Transactions on Affective Computing. 5:327-339
Emotion recognition from EEG signals allows the direct assessment of the “inner” state of a user, which is considered an important factor in human-machine-interaction. Many methods for feature extraction have been studied and the selection of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a695c1dd3d790c6cf52a005ccc3d1e0
https://doi.org/10.1109/taffc.2014.2339834
https://doi.org/10.1109/taffc.2014.2339834
Publikováno v:
Cancer Research. 79:2100-2100
Introduction: In patients with gastric cancer expressing high levels of c-met, inhibitors of the receptor tyrosine kinase (RTK) c-met are explored as targeted therapeutics. Unfortunately, clinical trials have failed to improve survival so far. This m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e2b38137657904cfd9cbcf286daf822
https://doi.org/10.1158/1538-7445.am2019-2100
https://doi.org/10.1158/1538-7445.am2019-2100