Differences in local immune cell landscape between Q fever and atherosclerotic abdominal aortic aneurysms identified by multiplex immunohistochemistry

Autor: Kimberley RG Cortenbach, Alexander HJ Staal, Teske Schoffelen, Mark AJ Gorris, Lieke L Van der Woude, Anne FM Jansen, Paul Poyck, Robert Jan Van Suylen, Peter C Wever, Chantal P Bleeker-Rovers, Mangala Srinivas, Konnie M Hebeda, Marcel van Deuren, Jos W Van der Meer, Jolanda M De Vries, Roland RJ Van Kimmenade

Publikováno v: eLife, Vol 11 (2022)

Background: Chronic Q fever is a zoonosis caused by the bacterium Coxiella burnetii which can manifest as infection of an abdominal aortic aneurysm (AAA). Antibiotic therapy often fails, resulting in severe morbidity and high mortality. Whereas previ

Externí odkaz: https://doaj.org/article/1e24405511e940f389f690a5a298a7af

Development and verification of new monoclonal orthopedia homeobox (OTP) specific antibodies for pulmonary carcinoid diagnostics

Autor: Laura Moonen, Jules L. Derks, Lisa M. V. Lap, Britney J. C. A. Marijnissen, Lisa M. Hillen, Michael A. den Bakker, Jan H. von der Thüsen, Robert-Jan van Suylen, Wim Timens, Maria Bintanel, Eugenia Kuteeva, Anne-Marie C. Dingemans, Ernst-Jan M. Speel

Publikováno v: Translational lung cancer research, 11(11), 2181-2191. AME PUBL CO
Translational Lung Cancer Research, 11(11), 2181-2191. Society for Translational Medicine (STM)
Translational Lung Cancer Research, 11(11), 2181-2191. AME Publishing Company

Background: Orthopedia homeobox (OTP) has shown to be a useful prognostic marker to predict outcome in pulmonary carcinoids, which is also supported by the World Health Organization. However, the discontinuation of the initially used polyclonal antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802ee343d91792b12d23a12a5739771b
https://doi.org/10.21037/tlcr-22-418

Supplementary Figure Legends from CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids

Autor: Ernst-Jan M. Speel, Frans C.S. Ramaekers, Manon van Engeland, Wim Van Criekinge, Marco Volante, Erik Thunnissen, Martina Rudelius, Annick Haesevoets, Winand N.M. Dinjens, Anne-Marie C. Dingemans, Robert-Jan van Suylen, Leander Van Neste, Mieke E.R. Henfling, Dorian R.A. Swarts

PDF file - 71K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cbca22d651b74a6e93eb2f2ff9e11f
https://doi.org/10.1158/1078-0432.22451982

Supplementary Figure 3 from CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids

Autor: Ernst-Jan M. Speel, Frans C.S. Ramaekers, Manon van Engeland, Wim Van Criekinge, Marco Volante, Erik Thunnissen, Martina Rudelius, Annick Haesevoets, Winand N.M. Dinjens, Anne-Marie C. Dingemans, Robert-Jan van Suylen, Leander Van Neste, Mieke E.R. Henfling, Dorian R.A. Swarts

PDF file - 1346K, Kaplan-Meier analysis showing 20-year overall survival rates for a combined group of carcinoids and high-grade neuroendocrine carcinomas. A gradient of OTP immunostaining is shown for the 312 out of 348 cases with available follow-u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f6425ba0683918a7a55ee4277c4506
https://doi.org/10.1158/1078-0432.22451985

Supplementary Figure 1 from CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids

Autor: Ernst-Jan M. Speel, Frans C.S. Ramaekers, Manon van Engeland, Wim Van Criekinge, Marco Volante, Erik Thunnissen, Martina Rudelius, Annick Haesevoets, Winand N.M. Dinjens, Anne-Marie C. Dingemans, Robert-Jan van Suylen, Leander Van Neste, Mieke E.R. Henfling, Dorian R.A. Swarts

Representative immunohistochemical staining patterns for CD44 (A), OTP (B) and RET (C). (A) Normal lung tissue adjacent to a carcinoid tumor showing CD44 staining of the bronchial epithelium BE and seromucous glands G (original magnification 100x). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326de9a43a7e6b84aaa66a58c9f101d4
https://doi.org/10.1158/1078-0432.22451991.v1