Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)Research in context

Autor: Nicholas I. Paton, Wolfgang Stöhr, Alejandro Arenas-Pinto, Amanda Clarke, Ian Williams, Margaret Johnson, Chloe Orkin, Fabian Chen, Vincent Lee, Alan Winston, Mark Gompels, Julie Fox, Karen Sanders, David T. Dunn, Martin Fisher, Wendy Hadley, David Stacey, Pat Byrne, Nahum De Esteban, Pierre Pellegrino, Lewis Haddow, James Hand, Carl De Souza, Lisa Murthen, Andrew Crawford-Jones, Ruth Wilson, Elizabeth Green, John Masterson, Kamlesh Patel, Rebecca Howe, Scott Mullaney, Louise Jennings, Nicholas Beeching, Rebecca Tamaklo, Alistair Teague, Isabelle Jendrulek, Juan Manuel Tiraboschi, Ed Wilkins, Yvonne Clowes, Andrew Thompson, Gary Brook, Manoj Trivedi, Kazeem Aderogba, Martin Jones, Andrew DeBurgh-Thomas, Liz Jones, Iain Reeves, Sifiso Mguni, David Chadwick, Pauline Spence, Nellie Nkhoma, Zoe Warwick, Suzanne Price, Sally Read, Elbushra Herieka, James Walker, Ruth Woodward, John Day, Laura Hilton, Veerakathy Harinda, Helen Blackman, Phillip Hay, Wendy Mejewska, Olanike Okolo, Edmund Ong, Karen Martin, Lee Munro, David Dockrell, Lynne Smart, Jonathan Ainsworth, Anele Waters, Stephen Kegg, Sara McNamara, Steve Taylor, Gerry Gilleran, Brian Gazzard, Jane Rowlands, Sris Allan, Rumun Sandhu, Nigel O'Farrell, Sheena Quaid, Fabiola Martin, Caroline Bennett, Moses Kapembwa, Jane Minton, James Calderwood, Frank Post, Lucy Campbell, Emily Wandolo, Adrian Palfreeman, Linda Mashonganyika, Thambiah Balachandran, Memory Kakowa, Rebecca O'Connell, Cheryl Tanawa, Sinna Jebakumar, Lesley Hagger, Say Quah, Sinead McKernan, Charles Lacey, Sarah Douglas, Sarah Russell-Sharpe, Christine Brewer, Clifford Leen, Sheila Morris, Sharmin Obeyesekera, Shirley Williams, Nelson David, Mark Roberts, Julie Wollaston, Nicholas Paton, Karen Scott, David Dunn, Emma Beaumont, Sue Fleck, Mark Hall, Susie Hennings, Ischa Kummeling, Sara Martins, Ellen Owen-Powell, Fionna van Hooff, Livia Vivas, Ellen White, Brian Angus, Andrew Freedman, Ben Cromerty, Danielle Mercey, Sarah Fidler, Estee Torok, Abdel Babiker, Tim Peto, David Lalloo, Andrew Phillips, Robert James

Publikováno v: EClinicalMedicine, Vol 69, Iss , Pp 102457- (2024)

Summary: Background: Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch strategy. Methods: Eligible participants attending 43 UK treatment centres had a

Externí odkaz: https://doaj.org/article/aefd2413e78d42f29d03d4ab013c1e5b

Effect of Dupilumab on Sleep Apnea Severity in Patients With Chronic Rhinosinusitis

Autor: Sang-Wook Kim, Scott A. Sands, Daniel Vena, Lauren B. Hess, Nicole A. Calianese, Robert James Konefal, Luigi Taranto-Montemurro, Ali Azarbarzin, Charles A. Czeisler, Tanya M. Laidlaw, Andrew Wellman

Publikováno v: Sleep Medicine Research, Vol 14, Iss 2, Pp 113-117 (2023)

Patients with chronic rhinosinusitis (CRS) report improved sleep quality after dupilumab, an anti IL4/13 therapy. Concurrent CRS and obstructive sleep apnea (OSA) cases are not rare, and CRS seemingly raises nasal resistance. Thus, we hypothesized th

Externí odkaz: https://doaj.org/article/7bc5d55cce524b0eb41a374b8d9390c5

Challenges and considerations in determining the quality of electronic performance & tracking systems for team sports

Autor: Sam Robertson, Grant Malcolm Duthie, Kevin Ball, Bartholomew Spencer, Fabio Rubens Serpiello, Jade Haycraft, Nicolas Evans, Johsan Billingham, Robert James Aughey

Publikováno v: Frontiers in Sports and Active Living, Vol 5 (2023)

Electronic performance & tracking systems (EPTS) are commonly used to track the location and velocity of athletes in many team sports. A range of associated applications using the derived data exist, such as assessment of athlete characteristics, inf

Externí odkaz: https://doaj.org/article/57efa566a03d4bd09ddd67ef8f4a3e1f

Preoperative Factors to Assess Risk for Postoperative Urinary Retention in Total Joint Arthroplasty: A Retrospective Analysis

Autor: Robert James Magaldi, BS, Sara Elaine Strecker, PhD, Carl W. Nissen, MD, Robert James Carangelo, MD, John Grady-Benson, MD

Publikováno v: Arthroplasty Today, Vol 13, Iss , Pp 181-187 (2022)

Background: Postoperative urinary retention (POUR) is a significant problem in total joint arthroplasty (TJA). Although risk factors for POUR have been well documented, they are ubiquitous in an aging total joint population, which makes risk stratifi

Externí odkaz: https://doaj.org/article/2f74e28e16c348af97798467ef8310dc

Allele expression biases in mixed-ploid sugarcane accessions

Autor: Fernando Henrique Correr, Agnelo Furtado, Antonio Augusto Franco Garcia, Robert James Henry, Gabriel Rodrigues Alves Margarido

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Allele-specific expression (ASE) represents differences in the magnitude of expression between alleles of the same gene. This is not straightforward for polyploids, especially autopolyploids, as knowledge about the dose of each allele is req

Externí odkaz: https://doaj.org/article/edf23f8029a24cd1aba304c8625b0745