Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Robert J. Winkfein"'
Autor:
Ruth M Williams, Robert J Winkfein, Rebecca S Ginger, Martin R Green, Paul P Schnetkamp, Grant N Wheeler
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180465 (2017)
NCKX5 is an ion exchanger expressed mostly in pigment cells; however, the functional role for this protein in melanogenesis is not clear. A variant allele of SLC24A5, the gene encoding NCKX5, has been shown to correlate with lighter skin pigmentation
Externí odkaz:
https://doaj.org/article/c91bcd42d9fe4299984c12b318e90352
Autor:
Jose Gp Ferraz, Douglas J. Demetrick, Marco Perizzolo, Shuhong Liu, Robert J. Winkfein, Martin Köbel, Young Ou, Subrata Ghosh, Marietta Iacucci, Peter F Rambau, Xianyong Gui
Publikováno v:
Journal of Clinical Pathology. 73:391-402
AimsInflammatory bowel disease (IBD)-associated precancerous lesions may be adenomatous or non-adenomatous with various histomorphologies. We aim to validate the newly proposed classification, to explore the neoplastic nature of the non-adenomatous l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8973a96622fb154ed7367d2a2065af
https://doi.org/10.1136/jclinpath-2019-206247
https://doi.org/10.1136/jclinpath-2019-206247
Autor:
Anna Carnini, Lucas O M Scott, Eva Ahrendt, Juliane Proft, Robert J Winkfein, Sung-Woo Kim, Michael A Colicos, Janice E A Braun
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37755 (2012)
Heat shock proteins (Hsps) are a set of molecular chaperones involved in cellular repair. They provide protective mechanisms that allow cells to survive potentially lethal insults, In response to a conditioning stress their expression is increased. H
Externí odkaz:
https://doaj.org/article/87a033898606447cb1abea8f219ee4c1
Autor:
Robert J. Winkfein, Tatiana P. Rogasevskaia, Paul P. M. Schnetkamp, Ali H. Jalloul, Frank Visser, Robert T. Szerencsei
Publikováno v:
Pigment Cell & Melanoma Research. 32:55-67
NCKX5 is a bidirectional K+ -dependent Na+ -Ca2+ exchanger, which belongs to the SLC24A gene family. In particular, the A111T mutation of NCKX5 has been associated with reduced pigmentation in European populations. In contrast to other NCKX isoforms,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e30516eb6b02dca53aa32bc313147eb
https://doi.org/10.1111/pcmr.12723
https://doi.org/10.1111/pcmr.12723
Autor:
Robert J. Winkfein, Pia A. Elustondo, Evgeny Pavlov, Andrey Y. Abramov, Matthew Smithen, Eleonora Zakharian
Publikováno v:
Cell Calcium. 54:86-94
Polyhydroxybutyrate (PHB) is a biological polymer which belongs to the class of polyesters and is ubiquitously present in all living organisms. Mammalian mitochondrial membranes contain PHB consisting of up to 120 hydroxybutyrate residues. Roles play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ccbbb0dac7235fe0f05fd6e4a8a3cd
https://doi.org/10.1016/j.ceca.2013.04.006
https://doi.org/10.1016/j.ceca.2013.04.006
Autor:
Cresson D. Fraley, Michael A. Colicos, Catherine Diao, Andrey Y. Abramov, Robert J. French, Robert J. Winkfein, Evgeny Pavlov, Michael R. Duchen
Publikováno v:
Proceedings of the National Academy of Sciences. 104:18091-18096
Polyphosphate (polyP) consists of tens to hundreds of phosphates, linked by ATP-like high-energy bonds. Although polyP is present in mammalian mitochondria, its physiological roles there are obscure. Here, we examine the involvement of polyP in mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64469481cbfc6b89279676ab854f6b5b
https://doi.org/10.1073/pnas.0708959104
https://doi.org/10.1073/pnas.0708959104
Autor:
Robert J. Winkfein, David Wilson, Enikö Kiss, Ning Chang, Susan Li, Cindy Sutherland, Eva Hesse, Michael P. Walsh, Mark Pho, William B. Wiehler, Claude Veillette
Publikováno v:
American Journal of Physiology-Cell Physiology. 292:C1417-C1430
S100A11 is a member of the S100 family of EF-hand Ca2+-binding proteins, which is expressed in smooth muscle and other tissues. Ca2+binding to S100A11 induces a conformational change that exposes a hydrophobic surface for interaction with target prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c32d15ee4116de3db726503248ae236
https://doi.org/10.1152/ajpcell.00439.2006
https://doi.org/10.1152/ajpcell.00439.2006
Autor:
Robert J. Winkfein, Robert T. Szerencsei, Haider F. Altimimi, Tashi G. Kinjo, Paul P. M. Schnetkamp, Yoshiyuki Shibukawa, KyeongJin Kang, P. Pratikhya
Publikováno v:
Annals of the New York Academy of Sciences. 1099:16-28
K+-dependent Na+/Ca2+ exchangers (NCKX) have been shown to play important roles in physiological processes as diverse as phototransduction in rod photoreceptors, motor learning and memory in mice, and skin pigmentation in humans. Most structure-funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dcd7f7824b7aca7f0a26f0ba8d30f9
https://doi.org/10.1196/annals.1387.054
https://doi.org/10.1196/annals.1387.054
Autor:
Tashi G. Kinjo, Paul P. M. Schnetkamp, Clemens F. M. Prinsen, KyeongJin Kang, Conan B. Cooper, Robert J. Winkfein, Robert T. Szerencsei
Publikováno v:
Annals of the New York Academy of Sciences. 976:41-52
Ca(2+) extrusion driven by both the inward Na(+) gradient as well as the outward K(+) gradient is essential for visual transduction in retinal rod and cone photoreceptors because it removes Ca(2+) that enters photoreceptors via the cGMP-gated and lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e22bc31e446fe74657ffbb9628072b
https://doi.org/10.1111/j.1749-6632.2002.tb04712.x
https://doi.org/10.1111/j.1749-6632.2002.tb04712.x
Publikováno v:
Biochemistry. 43:7940-7947
Cysteine residues play an important role in many proteins, either in enzymatic activity or by mediating inter- or intramolecular interactions. The Na(+)/Ca(2+)-K(+) exchanger plays a critical role in Ca(2+) homeostasis in retinal rod (NCKX1) and cone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b6dca175b29cfd8bc76597408fcd02
https://doi.org/10.1021/bi049538y
https://doi.org/10.1021/bi049538y