Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Robert J. Wenthold"'
Autor:
Nicolas H. Piguel, Sabine Fievre, Jean-Michel Blanc, Mario Carta, Maïté M. Moreau, Enora Moutin, Vera L. Pinheiro, Chantal Medina, Jerome Ezan, Léa Lasvaux, François Loll, Christelle M. Durand, Kai Chang, Ronald S. Petralia, Robert J. Wenthold, F. Anne Stephenson, Laurent Vuillard, Hervé Darbon, Julie Perroy, Christophe Mulle, Mireille Montcouquiol, Claudia Racca, Nathalie Sans
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 712-727 (2014)
The appropriate trafficking of glutamate receptors to synapses is crucial for basic synaptic function and synaptic plasticity. It is now accepted that NMDA receptors (NMDARs) internalize and are recycled at the plasma membrane but also exchange betwe
Externí odkaz:
https://doaj.org/article/8f27d3fd857744fca1150bb04ae3b89b
Publikováno v:
Journal of Neuroscience. 31:9289-9297
N-methyl d-aspartate receptors (NMDARs) are critical to the development of the nervous system, although their roles at axonal growth cones are unclear. We examined NMDAR localization and function at axonal growth cones of young hippocampal neurons. O
Autor:
Ronald S. Petralia, Ya-Xian Wang, Linna Ge, F.A. Stephenson, Arthur Zhou, Zhaohong Yi, Robert J. Wenthold, Fang Hua
Publikováno v:
Neuroscience. 167:68-87
NMDA receptors are found in neurons both at synapses and in extrasynaptic locations. Extrasynaptic locations are poorly characterized. Here we used preembedding immunoperoxidase and postembedding immunogold electron microscopy and fluorescence light
Autor:
John T.R. Isaac, Paul A. Roche, Young Ho Suh, Katherine W. Roche, Ronald S. Petralia, Robert J. Wenthold, Akira Terashima
Publikováno v:
Nature neuroscience
Regulated exocytosis is essential for many biological processes, and many components of the protein trafficking machinery are ubiquitous. However, there are also exceptions such as SNAP-25, a neuron-specific SNARE protein, which is essential for syna
Publikováno v:
FEBS Letters. 583:1226-1230
N-methyl-d-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the brain. Here we demonstrate interactions between the NR2A and NR2B subunits of NMDARs with flotillin-1 (flot-1), a lipid raft-associated protein. When mapped, anal
Publikováno v:
The Journal of Neuroscience. 28:3500-3509
NMDA receptors are glutamate-gated ion channels that play important roles in synaptic transmission and excitotoxicity. The functional NMDA receptor is thought to be a heterotetramer composed mainly of two NR1 and two NR2 subunits. Although it is gene
Autor:
Chang-Yu Wang, Kai Chang, Robert J. Wenthold, Ronald S. Petralia, Philip Y. Wang, Gail K. Seabold, Ya-Xian Wang
Publikováno v:
Journal of Biological Chemistry. 283:8395-8405
Synaptic adhesion-like molecules (SALMs) are a newly discovered family of adhesion molecules that play roles in synapse formation and neurite outgrowth. The SALM family is comprised of five homologous molecules that are expressed largely in the centr
Autor:
Ronald S. Petralia, Catherine Croft Swanwick, Nathalie Sans, Zhaohong Yi, Ya-Xian Wang, Kate Prybylowski, Zhanyan Fu, Stefano Vicini, Robert J. Wenthold
Publikováno v:
The Journal of Neuroscience. 27:11663-11675
The NMDA receptor is an important component of excitatory synapses in the CNS. In addition to its synaptic localization, the NMDA receptor is also present at extrasynaptic sites where it may have functions distinct from those at the synapse. Little i
Publikováno v:
Journal of Cell Science. 119:2995-3007
The plasma membrane Ca2+-ATPase-2 (PMCA2) is expressed in stereocilia of hair cells of the inner ear, whereas PMCA1 is expressed in the basolateral plasma membrane of hair cells. Both extrude excess Ca2+ from the cytosol. They are predicted to contai