Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Robert J. Trumbly"'
Autor:
Robert J. Trumbly
Publikováno v:
Molecular Analyses ISBN: 9781003247432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f7ce1f176d46161ea4100c21d808da
https://doi.org/10.1201/9781003247432-23
https://doi.org/10.1201/9781003247432-23
Autor:
Vijayasaradhi Setaluri, Caitlin E. Baum, Ivana L. de la Serna, Brandon Lewis, Thomas M. Blomquist, Tupa Basuroy, Robert J. Trumbly, Archit R. Trivedi, Aanchal Mehrotra, Fabian V. Filipp
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-18 (2020)
Epigenetics Chromatin 13:14 (2020)
Epigenetics & Chromatin
Epigenetics Chromatin 13:14 (2020)
Epigenetics & Chromatin
BackgroundPharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies have also implicated BET proteins as regulators of cell identity and differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc5d4c65f2e1a773a923abaa01ccad0
http://link.springer.com/article/10.1186/s13072-020-00333-z
http://link.springer.com/article/10.1186/s13072-020-00333-z
Autor:
Hussain N. Odeh, Julius N. De Castro, Robert J. Trumbly, Miranda L. Yeung, Kam C. Yeung, Christopher Figy
The majority of breast cancer-related deaths are due to metastasis. A special class of genes regulates the metastatic process. Metastatic genes that can enhance or suppress metastasis have been identified. Raf kinase inhibitor protein (RKIP) is a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad2086c0fca6e1dce2f76ee84d8353c
https://doi.org/10.1016/b978-0-12-819612-0.00009-2
https://doi.org/10.1016/b978-0-12-819612-0.00009-2
Autor:
Robert J. Trumbly, Kam C. Yeung, Ivana L. de la Serna, Ila Datar, Jungmin Choi, Gardiyawasam Kalpana
Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the BRaf genetic locus as one of the critical events in melanomagenesis. BRaf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f110c55bc757e0813edcd454b137c8af
https://doi.org/10.1101/413476
https://doi.org/10.1101/413476
Autor:
Sri Krishna Chaitanya Arudra, Kam C. Yeung, Gardiyawasam Kalpana, Jungmin Choi, Ila Datar, Ivana L. de la Serna, Michael D. McPhee, Robert J. Trumbly, Tupa Basuroy
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0204387 (2019)
Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the B-Raf genetic locus as one of the critical events in melanomagenesis. B-Raf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863f590c7a713d7686dabe45b9f526f0
https://pubmed.ncbi.nlm.nih.gov/30995246
https://pubmed.ncbi.nlm.nih.gov/30995246
Autor:
Xiaoliang Qiu, Ivana L. de la Serna, Kam C. Yeung, Jean Paul Thiery, Fahd Al-Mulla, Shweta Aras, Hongjuan Cui, Xuan Fan, Ila Datar, Robert J. Trumbly, Miranda Yeung, Hong Zhi Ma
Publikováno v:
Oncotarget
Accumulating evidence suggests that presence of macrophages in the tumor microenvironment add to the invasive and tumor-promoting hallmarks of cancer cells by secreting angiogenic and growth factors. RKIP is a known metastasis suppressor and interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46dd14bd48f500f59efde37da7d67fc
http://europepmc.org/articles/PMC4770756
http://europepmc.org/articles/PMC4770756
Publikováno v:
Biochemical and Biophysical Research Communications. 457:404-411
Estrogen (E2) supports breast cancer cell growth but suppresses invasiveness and both actions are antagonized by anti-estrogens. As a consequence, anti-estrogen treatment may increase the invasive potential of estrogen receptor (ER)+ tumor cell sub-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a2dcab873e4d8ca2362707e987f742
https://doi.org/10.1016/j.bbrc.2015.01.004
https://doi.org/10.1016/j.bbrc.2015.01.004
Autor:
Robert J. Trumbly, Suneethi Sivakumaran, Manohar Ratnam, Venkatesh Chari, Mugdha Patki, Mesfin Gonit
Publikováno v:
Journal of Biological Chemistry. 288:11047-11065
The androgen receptor (AR) is essential for diverse aspects of prostate development and function. Molecular mechanisms by which prostate cancer (PC) cells redirect AR signaling to genes that primarily support growth are unclear. A systematic search f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bffcef020307d3d9ad04953c25f0219
https://doi.org/10.1074/jbc.m112.438473
https://doi.org/10.1074/jbc.m112.438473
Autor:
M D Salazar, Robert J. Trumbly, Juan Zhang, Aymen Shatnawi, Mesfin Gonit, Lirim Shemshedini, Manohar Ratnam
Publikováno v:
Oncogene. 29:723-738
Nuclear expression of CCAAT enhancer binding protein-alpha (C/EBPalpha), which supports tissue differentiation through several antiproliferative protein-protein interactions, augurs terminal differentiation of prostate epithelial cells. C/EBPalpha is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa71d036140319ca875176771d97ea01
https://doi.org/10.1038/onc.2009.373
https://doi.org/10.1038/onc.2009.373
Autor:
Ivana L. de la Serna, Gang Ren, Fahd Al-Mulla, Ila Datar, Milad S. Bitar, Luis E. De Las Casas, Jingwei Feng, Robert J. Trumbly, Shweta Aras, Sri Krishna Chaitanya Arudra, John Lewandowski, Miranda Yeung, Xiaoliang Qiu, Hongjuan Cui, Kam C. Yeung
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0134494 (2015)
PLoS ONE, Vol 10, Iss 8, p e0134494 (2015)
Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ddb48f923d0e5e3e84d25f3c93b260
https://pubmed.ncbi.nlm.nih.gov/26308852
https://pubmed.ncbi.nlm.nih.gov/26308852