Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert J. Stumpo"'
Publikováno v:
Journal of Neurochemistry. 59:2087-2093
Neomycin appears as a full agonist and spermidine as a partial agonist at the site where polyamines enhance 1-[1-(2-thienyl)cyclohexyl][3H]piperidine ([3H]TCP) binding on the N-methyl-D-aspartate (NMDA) receptor. Other aminoglycosides also enhance [3
Autor:
Andre I. Salama, D. LaMonte, Thomas J. Mangano, Jitendra Patel, P. J. Warwick, William C. Zinkand, R. J. Powel, Richard A. Keith, M. Britt, Linda M. Pullan, Robert J. Stumpo, M. J. Chapdelaine
Publikováno v:
Journal of Neurochemistry. 55:1346-1351
HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enan
Publikováno v:
Journal of Autonomic Pharmacology. 10:213-220
1. The effects of the polyamines, spermine and spermidine on neuronal N-type voltage-sensitive calcium channels were investigated using the binding and function of the ligand omega-conotoxin GVIA (omega-CT). 2. Spermine and spermidine enhanced (EC50
Publikováno v:
NeuroReport. 5:148-150
In primary cultures of rat cerebral cortex, N-methyl-D-aspartate causes widespread neurotoxicity. Inhibitors of the nitric oxide generating the enzyme nitric oxide synthase has been shown to attenuate the effects of N-methyl-D-aspartate in a number o
Publikováno v:
European journal of pharmacology. 206(2)
omega-Conotoxin GVIA (omega-CT) has been reported to block calcium currents at the L- and N-type calcium channels. In neuronal membranes omega-CT, and the aminoglycoside antibiotic neomycin, have been shown to inhibit [125I]omega-CT binding, presumab
Autor:
Robert J. Stumpo, Maryann Britt, Andrea B. Klika, B.A. Meiners, Andre I. Salama, Linda M. Pullan, Richard J. Powell
Publikováno v:
European journal of pharmacology. 189(2-3)
The enantiomers of the strychnine-insensitive glycine antagonist, HA-966 (1-hydroxy-3-amino-pyrrolidone-2), stereoselectively enhance binding of the N-methyl-D-aspartate (NMDA) competitive antagonist, [3H]CPP (3-(2-carboxypiperazin-4-yl)propyl-1-phos
Autor:
Andre I. Salama, Thomas J. Mangano, Andrea B. Klika, Richard A. Keith, B.A. Meiners, Jitendra Patel, Robert J. Stumpo
Publikováno v:
European Journal of Pharmacology. 166:393-400
The role of endogenous glycine in supporting N-methyl-D-aspartate (NMDA)-evoked neurotransmitter release was investigated. HA-966 (1-hydroxy-3-aminopyrrolidone-2) inhibited NMDA-evoked release of [3H]norepinephrine from rat hippocampal brain slices,
Publikováno v:
European Journal of Pharmacology. 170:121-122
Investigation of the molecular site of L- and D-glutamine effects at the N-methyl-D-aspartate complex in neuronal membranes of rats by use of [ 3 H]TCP, N-(1-[2-thenyl]-cyclohexyl)-3,4-piperidine, binding