Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert J. Steininger"'
Autor:
Michael Ramirez, Satwik Rajaram, Robert J. Steininger, Daria Osipchuk, Maike A. Roth, Leanna S. Morinishi, Louise Evans, Weiyue Ji, Chien-Hsiang Hsu, Kevin Thurley, Shuguang Wei, Anwu Zhou, Prasad R. Koduru, Bruce A. Posner, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechan
Externí odkaz:
https://doaj.org/article/bd1a3c50ad1a402d9bff233756a1c84e
Autor:
Dinesh Kumar Singh, Chin‐Jen Ku, Chonlarat Wichaidit, Robert J Steininger, Lani F Wu, Steven J Altschuler
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-10 (2010)
Abstract Phenotypic heterogeneity has been widely observed in cellular populations. However, the extent to which heterogeneity contains biologically or clinically important information is not well understood. Here, we investigated whether patterns of
Externí odkaz:
https://doaj.org/article/e8a2075af1a94e1d9096728f3a622e40
Autor:
Steven J. Altschuler, Luc Girard, Lani F. Wu, Robert J. Steininger, Satwik Rajaram, John D. Minna
Publikováno v:
Cytometry Part A. 87:558-567
Microscopy reveals complex patterns of cellular heterogeneity that can be biologically informative. However, a limitation of microscopy is that only a small number of biomarkers can typically be monitored simultaneously. Thus, a natural question is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31260ebcfc7bf329a5e7f08747cf939d
https://doi.org/10.1002/cyto.a.22599
https://doi.org/10.1002/cyto.a.22599
Autor:
Shuguang Wei, Kevin Thurley, Steven J. Altschuler, Weiyue Ji, Anwu Zhou, Maike A. Roth, Chien Hsiang Hsu, Robert J. Steininger, Prasad Koduru, Michael Ramirez, Bruce A. Posner, Daria Osipchuk, Louise Evans, Satwik Rajaram, Lani F. Wu, Leanna S. Morinishi
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister' sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9084ebf3ef8e1edee11cd8680b6741fb
http://europepmc.org/articles/PMC4762880
http://europepmc.org/articles/PMC4762880
Autor:
Robert J, Steininger, Satwik, Rajaram, Luc, Girard, John D, Minna, Lani F, Wu, Steven J, Altschuler
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 87(6)
Microscopy reveals complex patterns of cellular heterogeneity that can be biologically informative. However, a limitation of microscopy is that only a small number of biomarkers can typically be monitored simultaneously. Thus, a natural question is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab4face44b5e6163ba9ef02155997346
https://pubmed.ncbi.nlm.nih.gov/25425168
https://pubmed.ncbi.nlm.nih.gov/25425168
Autor:
Jenny C. Barker, Jon P. Connelly, Matthew H. Porteus, Brian L. Ellis, Robert J. Steininger, Matthew L. Hirsch
Publikováno v:
Virology Journal
Background The ability to deliver a gene of interest into a specific cell type is an essential aspect of biomedical research. Viruses can be a useful tool for this delivery, particularly in difficult to transfect cell types. Adeno-associated virus (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f9a7e7d5ec8fd8c6ecb143b80d47c7
https://doi.org/10.1186/1743-422x-10-74
https://doi.org/10.1186/1743-422x-10-74
Autor:
Robert J. Steininger, Dinesh K. Singh, Chonlarat Wichaidit, Chin-Jen Ku, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Molecular Systems Biology
Non small cell lung cancer H460 clones exhibit a high degree of heterogeneity in signaling states. Clones with similar patterns of basal signaling heterogeneity have similar paclitaxel sensitivities. Models of signaling heterogeneity among the clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a786688c405810fbca4a5b014a959e84
https://pubmed.ncbi.nlm.nih.gov/20461076
https://pubmed.ncbi.nlm.nih.gov/20461076
Publikováno v:
Cancer Research. 75:760-760
One of the foremost challenges to cancer treatment is the emergence of drug resistance. Adding complexity to this problem is the recent realization that drug resistance can stem from selection for both intrinsically resistant subpopulations as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08712781de083154ba0e1980f69fdd53
https://doi.org/10.1158/1538-7445.am2015-760
https://doi.org/10.1158/1538-7445.am2015-760
Publikováno v:
Industrial & Engineering Chemistry Process Design and Development. 18:708-713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5edc5260fecb4c23f2f3dbeaa6619d1
https://doi.org/10.1021/i260072a023
https://doi.org/10.1021/i260072a023