Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert J. Steffens"'
Publikováno v:
Journal of Controlled Release. 20:13-19
The permeation of nicotine through human epidermis in vitro, membranes, adhesives, an adhesive-membrane laminate, and the laminate with epidermis was measured. Skin irritation in rabbits was shown to depend on the driving force of nicotine in the don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feeac418d15c7259ecc9f8ec41cae1ce
https://doi.org/10.1016/0168-3659(92)90134-d
https://doi.org/10.1016/0168-3659(92)90134-d
Autor:
BRET BERNER, DONALD R. WILSON, ROBERT J. STEFFENS, GERARD C. MAZZENGA, ROBERT HINZ, RICHARD H. GUY, HOWARD I. MAIBACH
Publikováno v:
Toxicological Sciences. 15:760-766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6292982e25a9cdf87969a3d46940f7f2
https://doi.org/10.1093/toxsci/15.4.760
https://doi.org/10.1093/toxsci/15.4.760
Autor:
Bret Berner, Robert J. Steffens, Wilson Donald R, Robert S. Hinz, Gerard C. Mazzenga, Howard I. Maibach, Richard H. Guy
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(4)
For a series of bases, which penetrate through human skin in vitro at similar rates (0.056–0.49 μ m /cm 2 /hr), penetrant p K a is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b221dc5f20561723848c6959505ec1e
https://pubmed.ncbi.nlm.nih.gov/2086317
https://pubmed.ncbi.nlm.nih.gov/2086317
Autor:
Bret Berner, Charles D. Ebert, Gerard C. Mazzenga, Rong-Hwei Juang, Robert J. Steffens, John H. Otte
Publikováno v:
Journal of pharmaceutical sciences. 78(5)
An optimal concentration range of aqueous ethanol produces 5–10-fold increases in nitroglycerin flux across skin and ethanol skin permeation that are far greater than reported previously. For aqueous ethanol solutions saturated with nitroglycerin w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f65c0306803966adaf0f934d4586e1
https://pubmed.ncbi.nlm.nih.gov/2501473
https://pubmed.ncbi.nlm.nih.gov/2501473
Publikováno v:
Journal of pharmaceutical sciences. 78(4)
The solution properties of aqueous ethanol donor solutions were characterized for the particular case of an increased flux nitroglycerin transdermal system. Permeation through porous and nonporous polymer membranes was investigated and modelled. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888eeb1b27dcd0dcdd01b81bb80151f0
https://pubmed.ncbi.nlm.nih.gov/2498509
https://pubmed.ncbi.nlm.nih.gov/2498509