Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert J. Steffens"'
Publikováno v:
Journal of Controlled Release. 20:13-19
The permeation of nicotine through human epidermis in vitro, membranes, adhesives, an adhesive-membrane laminate, and the laminate with epidermis was measured. Skin irritation in rabbits was shown to depend on the driving force of nicotine in the don
Autor:
BRET BERNER, DONALD R. WILSON, ROBERT J. STEFFENS, GERARD C. MAZZENGA, ROBERT HINZ, RICHARD H. GUY, HOWARD I. MAIBACH
Publikováno v:
Toxicological Sciences. 15:760-766
Autor:
Bret Berner, Robert J. Steffens, Wilson Donald R, Robert S. Hinz, Gerard C. Mazzenga, Howard I. Maibach, Richard H. Guy
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(4)
For a series of bases, which penetrate through human skin in vitro at similar rates (0.056–0.49 μ m /cm 2 /hr), penetrant p K a is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and
Autor:
Bret Berner, Charles D. Ebert, Gerard C. Mazzenga, Rong-Hwei Juang, Robert J. Steffens, John H. Otte
Publikováno v:
Journal of pharmaceutical sciences. 78(5)
An optimal concentration range of aqueous ethanol produces 5–10-fold increases in nitroglycerin flux across skin and ethanol skin permeation that are far greater than reported previously. For aqueous ethanol solutions saturated with nitroglycerin w
Publikováno v:
Journal of pharmaceutical sciences. 78(4)
The solution properties of aqueous ethanol donor solutions were characterized for the particular case of an increased flux nitroglycerin transdermal system. Permeation through porous and nonporous polymer membranes was investigated and modelled. Whil