Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Robert J. Schumacher"'
Clinical and microbiologic investigation of an expedited peri-implantitis dog model: an animal study
Autor:
Wook Jin Seong, Georgios Kotsakis, Jong-Ki Huh, Soo Cheol Jeong, Ki Young Nam, Jong Ryul Kim, Young Cheul Heo, Hyeon-Cheol Kim, Lei Zhang, Michael D. Evans, Heather Conrad, Robert J. Schumacher
Publikováno v:
BMC Oral Health, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Animal studies are pivotal in allowing experimentation to identify efficacious treatment protocols for resolution of peri-implantitis. The purpose of this investigation was to characterize an expedited dog peri-implantitis model c
Externí odkaz:
https://doaj.org/article/c5a3dba5164e429a80de6716ca89f4f6
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216669 (2019)
Antimicrobial peptides have been evaluated as possible alternatives to traditional antibiotics. The translational potential of the antimicrobial peptide DGL13K was tested with focus on peptide toxicity and in vivo activity in two animal models. DGL13
Externí odkaz:
https://doaj.org/article/f7532598aab5486f81ccca0d5ff11e63
Autor:
Trenton Callaway, Ronald A. Siegel, Allison Siehr, Craig M. Flory, Wei Shen, Robert J. Schumacher
Publikováno v:
ACS Biomaterials Science & Engineering. 7:5598-5610
Biodegradable and implantable materials having elastomeric properties are highly desirable for many biomedical applications. Here, we report that poly(lactide)-co-poly(β-methyl-δ-valerolactone)-co-poly(lactide) (PLA-PβMδVL-PLA), a thermoplastic t
Autor:
Zhijun Guo, Jianxun Lei, Hrishi Venkatesh, David Owen, Adam Bass, Christine Cannon, Joshua McCarra, Brenda Koniar, Craig Flory, Beverly Norris, Robert J. Schumacher, Swaathi Jayaraman, John Hawse, Emmanuel S. Antonarakis, Emanuel F. Petricoin, Julia Wulfkuhle, Robert D. Cardiff, Elizabeth A. Ambrose, Gunda I. Georg, Kaylee L. Schwertfeger, Michael A. Farrar, Brad St. Croix, Matthew P. Goetz, David A. Potter
Publikováno v:
Cancer Research. 83:LB102-LB102
Introduction: Immune checkpoint blockade (ICB) has clinical activity in triple negative breast cancer (TNBC) but is less effective in the ER+HER2- signature, where there is a cold immune microenvironment (IM) and regulatory T cells (Tregs) may suppre
Autor:
Robert J. Schumacher, Nicole Larson, Timothy P. Rich, Margaret A. Mysz, Beverly Norris, Lia G. Coicou, Brenda Koniar, Craig M. Flory, David H. Ingbar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Acute respiratory distress syndrome (ARDS) is a severe, life-threatening form of respiratory failure characterized by pulmonary edema, inflammation, and hypoxemia due to reduced alveolar fluid clearance (AFC). Alveolar fluid clearance is required for
Autor:
Hiroshi Hiasa, Delaney E Hart, Sarah R.C. Lentz, Tyrell R. Towle, Lisa M. Oppegard, Robert J. Kerns, Justine L. Delgado, Beverly Norris, Chaitanya A. Kulkarni, Craig M. Flory, Daryl J. Murry, Bridget P. Williams, Robert J. Schumacher
Publikováno v:
Investigational New Drugs. 37:378-383
Fluoroquinolone-class agents selectively target the bacterial type IIA topoisomerases DNA gyrase and topoisomerase IV, with a few exceptions that target eukaryotic type IIA topoisomerases. Fluoroquinolones bind and stabilize type IIA topoisomerase-DN
Autor:
Jianxun Lei, Gunda I. Georg, Matthew P. Goetz, David Potter, Beverly Norris, Ilia G. Denisov, Stephen Sliga, Robert J. Schumacher, John R. Hawse, Swaathi Jayaraman, Irina F. Sevrioukova, Zhijun Guo, Tom Poulos, Craig M. Flory, Connor M. McDermott, Kwon Ho Hong, Elizabeth A. Ambrose
Publikováno v:
Cancer Research. 81:LB078-LB078
Introduction: Small molecule therapeutics of estrogen receptor-positive/HER2-negative breast cancer remains an area of active investigation where novel agents are greatly needed for treatment of hormone therapy resistant metastatic disease. The bigua
Clinical and microbiologic investigation of an expedited peri-implantitis dog model: an animal study
Autor:
Ki Young Nam, Michael D. Evans, Heather J. Conrad, Jong Ryul Kim, Georgios A. Kotsakis, Soo Cheol Jeong, Hyeon-Cheol Kim, Lei Zhang, Wook Jin Seong, Young Cheul Heo, Robert J. Schumacher, Jong-Ki Huh
Publikováno v:
BMC Oral Health
BMC Oral Health, Vol 19, Iss 1, Pp 1-11 (2019)
BMC Oral Health, Vol 19, Iss 1, Pp 1-11 (2019)
Background Animal studies are pivotal in allowing experimentation to identify efficacious treatment protocols for resolution of peri-implantitis. The purpose of this investigation was to characterize an expedited dog peri-implantitis model clinically
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216669 (2019)
PLoS ONE
PLoS ONE
Antimicrobial peptides have been evaluated as possible alternatives to traditional antibiotics. The translational potential of the antimicrobial peptide DGL13K was tested with focus on peptide toxicity and in vivo activity in two animal models. DGL13
Autor:
Beverly Norris, Rebecca A. D. Cuellar, Satish Patil, Robert J. Schumacher, Bruce R. Blazar, Lev G Lis, Raj Suryanarayanan, Vadim J. Gurvich, Monique Morgan, Gunda I. Georg
Publikováno v:
Journal of Medicinal Chemistry
A disodium phosphonooxymethyl prodrug of the antitumor agent triptolide was prepared from the natural product in three steps (39% yield) and displayed excellent aqueous solubility at pH 7.4 (61 mg/mL) compared to the natural product (17 μg/mL). The