Zobrazeno 1 - 10
of 553
pro vyhledávání: '"Robert J. Schneider"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Inherited metabolic disorders arise from mutations in genes involved in the biogenesis, assembly, or activity of metabolic enzymes, leading to enzymatic deficiency and severe metabolic impairments. Metabolic enzymes are essential for the normal funct
Externí odkaz:
https://doaj.org/article/6a71e25f417c4d1a87faac79a6d0a23e
Autor:
Amandine Alard, Olga Katsara, Tiffany Rios-Fuller, Columba de la Parra, Ugur Ozerdem, Amanda Ernlund, Robert J. Schneider
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112646- (2023)
Summary: Cancer cell plasticity enables cell survival in harsh physiological environments and fate transitions such as the epithelial-to-mesenchymal transition (EMT) that underlies invasion and metastasis. Using genome-wide transcriptomic and transla
Externí odkaz:
https://doaj.org/article/5b23762f89c743d89372c74a2a203732
Autor:
Viviana Volta, Sandra Pérez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an al
Externí odkaz:
https://doaj.org/article/4045d5672d59446ca9d6d5c7a59cca09
AUF1 gene transfer increases exercise performance and improves skeletal muscle deficit in adult mice
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 222-236 (2021)
Muscle function and mass begin declining in adults long before evidence of sarcopenia and include reduced mitochondrial function, although much remains to be characterized. We found that mRNA decay factor AU-rich mRNA binding factor 1 (AUF1), which s
Externí odkaz:
https://doaj.org/article/87f7bc3a86ac4d28bf86668fa01b2274
Autor:
Hayley Wiers, Robert J. Schneider
Publikováno v:
Journal of Transport and Land Use, Vol 15, Iss 1 (2022)
Transportation planners, engineers, and researchers have long lamented the highly emotional public responses generated by changes to parking policies. We know that reducing the supply and increasing the price for parking—while intended to advance s
Externí odkaz:
https://doaj.org/article/7d9062032f12418084d51fb49497b47b
Autor:
Hossam Taha Mohamed, Aya Ali El-Sharkawy, Mohamed El-Shinawi, Robert J. Schneider, Mona Mostafa Mohamed
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Inflammatory breast cancer (IBC) is a highly aggressive phenotype of breast cancer that is characterized by a high incidence early metastasis. We previously reported a significant association of human cytomegalovirus (HCMV) DNA in the carcinoma tissu
Externí odkaz:
https://doaj.org/article/b2078dcde1ef419297cc014d37236cbd
Autor:
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in m
Externí odkaz:
https://doaj.org/article/c5802b4ff1e54135a67ab96e212ab5fd
Publikováno v:
Findings (2021)
This study summarizes University of Wisconsin-Milwaukee (UWM) campus commute mode shifts during COVID-19. The greatest shifts were to telecommuting and away from public transit. These shifts were uneven across the campus population: respondents with
Externí odkaz:
https://doaj.org/article/6195f3b0fba24153ac2469328930d5e3
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Translatomics data, particularly genome-wide ribosome profiling and polysome profiling, provide multiple levels of gene regulatory information that can be used to assess general transcription and translation, as well translational
Externí odkaz:
https://doaj.org/article/d49f42efa7254166bfc6d86072f8940d
Autor:
Columba de la Parra, Amanda Ernlund, Amandine Alard, Kelly Ruggles, Beatrix Ueberheide, Robert J. Schneider
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Binding of eIF4E to the 5′ cap of mRNAs is a key early step in canonical translation initiation, but the requirement for eIF4E is not universal. Here the authors show that the eIF4G homolog DAP5 interacts with eIF3 to promote cap-dependent translat
Externí odkaz:
https://doaj.org/article/750fa7f27de34646a8ea452e76018a5c