Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Robert J. Roon"'
Autor:
Michael B. Robinson, James F. Koerner, Shankar Venkatraman, Rodney L. Johnson, Robert J. Roon, Christopher J. Tokar, Louis Littman
Publikováno v:
Journal of Medicinal Chemistry. 42:1639-1647
The conformationally constrained cyclobutane analogues of quisqualic acid (Z)- and (E)-1-amino-3-[2'-(3',5'-dioxo-1',2', 4'-oxadiazolidinyl)]cyclobutane-1-carboxylic acid, compounds 2 and 3, respectively, were synthesized. Both 2 and 3 stimulated pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a62090b5d5d69cb0c3c63b3cb517ec
https://doi.org/10.1021/jm9806897
https://doi.org/10.1021/jm9806897
Autor:
Robert J. Roon, James F. Koerner
Publikováno v:
Brain Research. 734:223-228
Exposure of slices of rat hippocampus to quisqualic acid produces an enhanced sensitivity of neurons to depolarization by other excitatory amino acid analogues, particularly amino acid phosphonates. The phosphonates may act at extracellular sites, si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b96e988cb6f8cda927bbaf8352545aa
https://doi.org/10.1016/0006-8993(96)00634-8
https://doi.org/10.1016/0006-8993(96)00634-8
Publikováno v:
Journal of Medicinal Chemistry. 37:3939-3946
The ability of quisqualic acid (1) to sensitize neurons to depolarization by omega-phosphono alpha-amino acid analogues of excitatory amino acids is a highly specific phenomenon and is termed the QUIS effect. In an attempt to elucidate the structure-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3697cccf67f5540da4160a6fab75a6
https://doi.org/10.1021/jm00049a013
https://doi.org/10.1021/jm00049a013
Publikováno v:
Brain Research. 649:203-207
Brief exposure of rat hippocampal slices to quisqualic acid (QUIS) sensitizes neurons to depolarization by the α-amino-ω-phosphonate excitatory amino acid (EAA) analogues AP4, AP5 and AP6. These phosphonates interact with a novel QUIS-sensitized si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3453f1e55031817086b955f95648299c
https://doi.org/10.1016/0006-8993(94)91065-0
https://doi.org/10.1016/0006-8993(94)91065-0
Publikováno v:
Brain Research. 605:85-92
Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2a7fa9fda12c7f5fea3336a7594625
https://doi.org/10.1016/0006-8993(93)91359-z
https://doi.org/10.1016/0006-8993(93)91359-z
Publikováno v:
Journal of Medicinal Chemistry. 35:4602-4607
Hippocampal CA1 pyramidal cell neurons are sensitized over 30-fold to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid. This phenomenon has been termed the QUIS effect. In the present study several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304dbe884dc0e9aa84849869a86fbc4f
https://doi.org/10.1021/jm00102a014
https://doi.org/10.1021/jm00102a014
Publikováno v:
Journal of medicinal chemistry. 38(22)
The syntheses of several novel N-(hydroxydioxocyclobutenyl)-containing analogues of gamma-amino-butyric acid and L-glutamate were undertaken to test the hypothesis that derivatives of 3,4-dihydroxy-3-cyclobutene-1,2-dione (squaric acid), such as 3-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491a38be0439239e5f308a0ba38c07ea
https://pubmed.ncbi.nlm.nih.gov/7473569
https://pubmed.ncbi.nlm.nih.gov/7473569
Autor:
Michael Y. M. Chan, James F. Koerner, Marvin K. Schulte, Nalin L. Subasinghe, Robert J. Roon, Rodney L. Johnson
Publikováno v:
Journal of medicinal chemistry. 33(10)
The following structural and conformationally constrained analogues of Ac-Asp-Glu-OH (1) were synthesized: Ac-Glu-Glu-OH (2), Ac-D-Asp-Glu-OH (3), Ac-Glu-Asp-OH (4), Ac-Asp-Asp-OH (5), Ac-Asp-3-aminohexanedioic acid (6), Ac-3-amino-3-(carboxymethyl)p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58b8fa4461f2e06bac9a89bed0e5434
https://pubmed.ncbi.nlm.nih.gov/2213826
https://pubmed.ncbi.nlm.nih.gov/2213826
Autor:
Meenakshi Tiwary, Robert J. Rooney, Swantje Liedmann, Kim S. LeMessurier, Amali E. Samarasinghe
Publikováno v:
Cells, Vol 10, Iss 3, p 509 (2021)
Eosinophils, previously considered terminally differentiated effector cells, have multifaceted functions in tissues. We previously found that allergic mice with eosinophil-rich inflammation were protected from severe influenza and discovered speciali
Externí odkaz:
https://doaj.org/article/60618182d8cf48bfadecbc1947cba90d
Autor:
Kyu Won Kim, Robert J. Roon
Publikováno v:
Biochemistry. 22:2704-2707
Asparaginase II of Saccharomyces cerevisiae is a cell wall mannan containing glycoprotein. Recent studies have demonstrated that asparaginase II activity increases in exponentially growing cell cultures and then decreases as the cells enter the stati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba34c20e22820d8b7661c46464f383
https://doi.org/10.1021/bi00280a018
https://doi.org/10.1021/bi00280a018